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Biomedical subjects

H Lie

Publications and source records attributed to H Lie.

15 recordsLinked to original sources
PubMed1992

Concomitant occurrence of mucopolysaccharidosis IIIB and Glanzmann's thrombasthenia. Further evidence of a hyperactive alpha-N-acetylglucosaminidase-producing allele.

A daughter of first cousins had two extremely rare, recessive disorders: thrombasthenia (Glanzmann's disease, glycoprotein IIb/IIIa deficiency) and mucopolysaccharidosis IIIB, (Sanfilippo B syndrome, alpha-N-acetylglucosaminidase (NAG) deficiency). Normal alpha-N-acetylglucosaminidase activity was observed in two obligate heterozygotes (the proband's father and her maternal grandmother), suggesting that in addition to the normal and defective alleles, a third, hyperactive allele is also present in this family. Such a hyperactive allele seems to be quite prevalent in our area, and makes the biochemical identification of heterozygotes impossible if no extensive family surveys provide additional clues. There was no linkage between the two diseases, nor between any of them and several blood-groups and HLA-antigens tested for.

Acetylglucosaminidase↗
PubMed1992

Fibrinolytic activity as a predictor of the outcome of prolapsed intervertebral lumbar disc surgery with reference to background variables: results of a prospective cohort study.

In a prospective study 122 patients with a slipped lumbar disc and no previous surgery were preoperatively examined for fibrinolytic activity. Surgical results for these patients were evaluated 12 months postoperatively by clinical overall assessment. In a multiple linear regression analysis fibrinolytic variables, euglobulin clot lysis time and plasminogen activator inhibitor 1, were shown to have predictive value regarding outcome of surgery; that is, normal fibrinolytic activity favors a satisfactory outcome and vice versa. Background variables and lipid profile were also recorded preoperatively. Body mass index, gamma-glutamyl transpeptidase, triglycerides and smoking were of statistical significance in relation to euglobulin clot lysis time and plasminogen activator inhibitor 1. Postoperative fibrinolytic re-examination of 20 patients seem to confirm that patients at risk of surgical failure have a prolonged depression of fibrinolytic activity.

Cohort Studies↗
PubMed1990

[Etiology and diagnosis of chronic back pain].

Chronic low back pain is lumbar-sciatic pain of more than 3 months duration. It is necessary to classify back conditions into conditions with and without nerve root affection. In addition to herniated discs, spinal stenosis and intra- or extramedullary tumours, transdiscal ruptures may cause radicular symptoms and signs from a local inflammatory effect caused by the nucleus material affecting the epidural tissue. Low back pain without radicular affection accounts for 95% of all cases of chronic low back disability. Symptoms and signs, x-ray investigations, and laboratory data are dealt with in the structural and focal etiology of the pain. The relationship between psycho-social factors and low back pain is discussed.

Adult↗
PubMed1990

[Discography].

Discography means imaging of the intervertebral discs by intradiscal contrast injections. Discography with a combined CT/discography allows a more detailed classification of annular disruption and degeneration. Combined with a pain response registration, discography can be of value in the diagnosis of chronic low back pain with signs of sciatica in cases where other x-ray modalities have failed to explain the source of pain. Among 20 discography examinations there was a correlation between radicular symptoms and annular disruption with contrast leakage to the epidural space, and disc protrusion on CT scanning.

Back Pain↗
PubMed1990

[Therapeutic principles in chronic back pain].

Treatment of patients with chronic back pain may become a most difficult task. This article discusses the principles and indications for surgical treatment. Conservative treatment should emphasize information and exercises to increase function. Soft tissue treatment, manipulation, and poor pain treatment should be used as supplements, and not as alternatives to this treatment. Contra-indications to physiotherapy are discussed to the extent that ordination of treatment that is not well-founded may have unfortunate therapeutic consequences. The general practitioner should act as coordinator when a more extensive somatic and psycho-social rehabilitation programme is required.

Back Pain↗
PubMed1990

[Low back pain malingering].

As in the case of other painful conditions, patients with low back pain may exhibit symptoms of malingering and of decreased function. This may occur at a conscious or a subconscious level. Certain signs in the case history and the clinical examination are typical of malingerers. Local treatment of symptoms may cause an exaggeration of the patients decreased function. Treatment should focus on possible underlying psycho-social problems. Sick leave should be avoided if possible during the treatment period.

Back Pain↗
PubMed1985

Coronary risk factors and incidence of coronary death in relation to physical fitness. Seven-year follow-up study of middle-aged and elderly men.

Physical fitness was assessed in relation to a near maximal bicycle exercise test in two populations; population 1: 122 middle aged and elderly cross-country skiers with a documented very high physical performance, and population 2: 2014 apparently healthy men 40-59 years of age. All were without known or suspected heart disease at the baseline study. A number of so-called coronary risk factors were studied simultaneously. The total incidence of coronary heart disease (CHD) events were noted as was the total 7 year incidence of death from CHD among men from population 2. By subdividing the latter in quartiles of physical fitness within each 5 year age group--and studying levels of coronary risk factors and CHD deaths within these 16 subgroups--the following findings were made: All coronary risk factors were favourably and strongly associated with high physical fitness and vice versa in a consistent way. Death from myocardial infarction and sudden, unexpected death followed the same pattern in an inverse way. The skiers as a group closely followed the most fit men from population 2 in all respects. Thus we have noted a strong, graded, positive association between physical fitness and a number of coronary risk factors, and an inverse relationship between high physical fitness and the risk of dying from CHD. These findings hold true for a period of 7 years among middle aged men free from known or suspected heart disease.

Adult↗
PubMed1985

Significance of a positive exercise ECG in middle-aged and old athletes as judged by echocardiographic, radionuclide and follow-up findings.

To study the pathologic and prognostic significance of--and possible underlying mechanisms for--a pathological exercise ECG in athletes, two age-matched groups were selected from a total population of 117 middle-aged and old endurance athletes: Group A: 21 with a pathological exercise-ECG, and group B: 21 with normal exercise-ECGs. Data from 201-thallium perfusion scintigraphy, 99 m-technetium multiple gated acquisition ventriculography (MUGA), resting echocardiography and 3 years follow-up are as follows: None had thallium findings indicating reversible myocardial ischaemia, but one from group A had a probable old myocardial infarction. All had normal resting MUGA, but group A men slightly more often presented a subnormal increase in ejection fraction according to exercise MUGA than group B men (9/20 vs 4/21). The former also more often had ventricular hypertrophy (LVH) (19/21 vs 14/21). However, apart from slightly longer ventricular filling time among group A men the echocardiograms revealed no group differences e.g. in cardiac dimensions or in indices of systolic or diastolic function. Regardless of exercise-ECG response, 18/42 athletes had one or more value of left ventricular dimensions or diameter exceeding the 95th percentile of the normal range. Since one patient from group A had asymmetric septal hypertrophy, one developed cardiomyopathy during the 3 years follow-up and one had a previous myocardial infarction, only 3/21 had cardiac disease which might explain the pathological exercise-ECG. Thus, pathological exercise-ECG rarely signifies heart disease in athletes, and very rarely coronary heart disease. Rather, the pathological exercise-ECG may be related to LVH and various subtle alterations in cardiac physiology following long-term endurance training.

Adult↗
PubMed1978

ECG aberrations, latent coronary heart disease and cardiopulmonary fitness in various age groups of Norwegian cross-country skiers.

To assess the prevalence of possible, latent coronary heart disease (CHD) among physically active men, 149 elite cross-country skiers in three age groups (26-33, 43-50 and 58-64 years) were invited for an examination which included clinical examination, Vitalogram, resting ECG, and a near maximal bicycle test. Of the invited men, 122 participated, i.e. 81.8%. The following findings were made: Normal clinical findings in all except 2, low resting heart rate, lung function parameters of about normal mean; voltage signs of left ventricular hypertrophy in resting ECG in 61/122, incomplete right bundle branch block in 14/122, codable Q waves (Minnesota Code, MC) in 5/87 from the highest age groups, ischaemic exercise ECG changes of MC 4.1 or 4.2 types in 11/87 vs. 1/35 in the two oldest vs. the youngest age group. Physical performance was very high in all age groups, but regular training did not seem to inhibit the normal age-dependent decline in physical performance. The resting and exercise ECG data in the two oldest age groups did not differ favourably from similar data obtained in sedentary men of the same age from approximately the same geophraphic area. Thus, it is possible that regular strenuous exercise and training may not protect against the development of CHD. The implications of such a view are briefly discussed.

Adult↗