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Biomedical subjects

H Liddell

Publications and source records attributed to H Liddell.

12 recordsLinked to original sources
PubMed1996

Serum concentrations of human chorionic gonadotrophin and immunoreactive inhibin in early pregnancy and recurrent miscarriage: a longitudinal study.

Serum concentrations of immunoreactive inhibin (ir-inhibin) and human chorionic gonadotrophin (HCG) have been measured during the first trimester in a longitudinal study of pregnant women attending a recurrent miscarriage clinic. In 30 singleton pregnancies (Group 1) that continued successfully to term, the median concentration of ir-inhibin initially declined from 1,140 pg/mL at week 4-5 then rose back to comparable values between weeks 7 and 10 but to decline again to reach the significantly lower level of 840 pg/mL (p < 0.01) at week 15-16. Serum levels of HCG showed the classical profile of normal pregnancy reaching a median peak value of 65,600 IU/L (1st IRP) at week 8-9. In 7 pregnancies that miscarried but earlier had evidence on ultrasound of an active fetal heart, HCG levels in the first 9 weeks were consistently below the 10th percentile for Group 1 pregnancies (p < 0.001). Levels of ir-inhibin were also suppressed but to a lesser extent. In 6 of 7 a fetal pregnancies, HCG levels during the first 9 weeks were again markedly subnormal. The levels of ir-inhibin varied between high normal and subnormal. In none of the pregnancy groups was a correlation found between ir-inhibin and HCG concentrations. In a single pregnancy with an anencephalic fetus, while levels of ir-inhibin and HCG were not depressed, peak values were not reached until week 12. The study shows that the level of ir-inhibin in the maternal serum in early pregnancy is of little value as a prognostic indicator of pregnancy outcome. It confirms that a subnormal HCG level is a useful predictor of early pregnancy failure.

Abortion, Habitual↗
PubMed1993

Menorrhagia.

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Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1985

Controlled trial of treatment of recurrent spontaneous abortion by immunisation with paternal cells.

In a paired sequential double-blind trial of immunological treatment of recurrent spontaneous abortion successful outcome of the next pregnancy was significantly more common in women injected with purified lymphocytes prepared from their husbands' blood than in those injected with their own lymphocytes. 17 of 22 women given paternal cells had successful pregnancies, compared with 10 of 27 given their own cells.

Abortion, Habitual↗
PubMed1985

The elderly and the medication label: doing it better.

Sixty elderly patients, responsible for taking their medication after discharge, were studied prior to their discharge from hospital. Sixty per cent had problems reading their medication labels and a similar percentage did not have a clear understanding of the labelled directions. The purpose of 54% of the 163 prescribed medicines was unknown to the patients. Some difficulty was experienced with the commonly used 'scriptwriter' typeface and better alternatives are suggested. Greater attention to the medication label, in conjunction with other measures shown to improve compliance, and the development of a unit policy would facilitate better prescribing.

Aged↗