[Amino acid metabolism in infection].
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Amino Acids↗
Biomedical subjects
H Leweling
Publications and source records attributed to H Leweling.
Influence of an orally administered protein mixture enriched in branched chain amino acids on the chronic hepatic encephalopathy (CHE) of patients with liver cirrhosis.
8 patients with liver cirrhosis and chronic hepatic encephalopathy (CHE) stage I and II on a protein restricted diet and partly on lactulose therapy received in alternate periods of 4 to 8 weeks a) 45 g/day of a protein mixture enriched in branched chain amino acids (BCAA-protein), b) the same amount of milk protein and c) an isocaloric carbohydrate mixture. The additional amount of protein in form of BCAA-protein was well tolerated by all the patients. Patients with and without additional lactulose therapy showed a tendency to improvement in the performance of the number connection test while on BCAA-protein, but this improvement did not reach statistical significance. The patients did not tolerate milk protein given in the same amount as BCAA-protein.
Administration, Oral↗
[Effect of parenteral amino acid administration on the brain function and the serum aminogram of patients with liver cirrhosis].
10 patients with cirrhosis of the liver, 5 with hepatic encephalopathy, were treated by infusion therapy with an amino acid solution adapted to the metabolic conditions seen in hepatic insufficiency. In all cases the amino acid imbalance improved. In 11 episodes of hepatic coma, changes in the pattern of serum amino acids always were accompanied by a marked decrease of elevated ammonia levels and a restitution of clear consciousness. This clinical improvement developed rather rapidly and could be objectivated impressively by psychometric tests.
Adult↗
[Use of different parenterally administered amino acid solutions with healthy test subjects].
We studied the alterations in the pattern of free serum amino acids during continuous parenteral infusion of 4 different standardised L-amino acid solutions. Nearly for all amino acids, a dose-dependent steady state could be established, usually as early as 30 or 60 minutes after starting the infusion. Amino acid solutions that caused the smallest changes of the amino acid pattern in plasma during infusion produced always the smallest increase of total amino acid nitrogen and the greatest rate of amino acid transfer. So we conclude that these solutions are utilised most effectively.
Adult↗