[Avoid physicians' beepers!].
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Biomedical subjects
Publications and source records attributed to H Levander.
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Objective criteria for suspected early postoperative infections after arthroplastic surgery are sparse. In order to establish the usual time course of some inflammatory laboratory values after hip and knee arthroplasty, these values were followed prospectively in nine patients. C-reactive protein in serum was normalised within about two weeks. On discharge 14 days postoperatively the erythrocyte sedimentation rate was still high (mean 64 mm/h), but at follow-up four months after operation it was restored to normal. The total blood leucocyte count remained essentially within normal limits throughout the postoperative period. The morning temperature was slightly raised, to about 38 degrees C in a few patients on the first and second days postoperatively, but was otherwise normal.
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Iron deficiency anaemia was produced by repeated phlebotomies in three healthy males. The storage iron was estimated as 666, 522 and 750 mg. After treatment with 1 000 mg of Ferastral the blood haemoglobin concentration rose at an average daily rate of 0.1 g/100 ml/day. Ninety per cent of the injected iron could be accounted for, and the utilization was estimated to about 70-80%. Side effects comprised pain and discolouration at the injection site.
Serum ferritin and erythrocyte 2,3-DPG levels were followed in 3 healthy males who were phlebotomized to iron depletion and a moderate anaemia. In 2 of the subjects, the expected rise in DPG levels was seen but not in the third, in spite of a Hb concentration of 95 g/1. Serum ferritin levels were found to reflect changes in iron stores, and subnormal serum ferritin indicated depleted iron stores. However, there was no correlation between pre-phlebotomy ferritin levels and calculated iron stores. The conclusion is that no fixed ratio can be established between serum ferritin and iron stores. A single ferritin value within the normal range does not tell how large iron stores a person has. Changes in an individual's iron stores can, however, be detected by repeated ferritin estimations.
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