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Biomedical subjects

H Leriche

Publications and source records attributed to H Leriche.

42 records · Page 3Linked to original sources

[Non-surgical treatment of pulmonary valve stenosis].

Percutaneous pulmonary valve valvuloplasty was attempted 17 times in 16 infants and children aged 15 days to 18 years. Valvuloplasty was performed during cardiac catheterization without general anesthesia. Balloon catheter was positioned across the pulmonary valve using a guide wire previously introduced in the right or left pulmonary artery. All patients experienced a decrease in the right ventricular peak systolic pressure from 111.5 +/- 35.9 to 69 +/- 28.9 mmHg (p less than 0.001), a decrease in the ratio of right ventricular pressure to systemic systolic pressure from 1.08 +/- 0.34 to 0.65 +/- 0.28 (p less than 0.001) and a decrease in right ventricular to pulmonary artery gradient from 88.52 +/- 37.2 to 54.82 +/- 29.4 mmHg (p less than 0.001). A child with a history of postoperative seizures had convulsions after the procedure and died 72 hours later. Four other patients are considered as a failure of the technique, 4 had clear hemodynamic improvement but right ventricular pressure remained above 50 mmHg, and 8 had satisfactory relief of their stenosis with a right ventricular pressure below or equal to 50 mmHg and a right ventricular to pulmonary artery gradient below 30 mmHg. These good results were confirmed in 2 patients, one year after the dilatation. Percutaneous balloon valvuloplasty is probably now the best treatment for pulmonary valvular stenosis. Short-term and results at distance from the procedure are good, and morbidity and cost are less than those for a surgical cure.

Adolescent↗

[Treatment of rheumatic mitral stenosis in children and adolescents by a balloon catheter].

Between April 1986 and August 1987, eight children, 9 to 18 years old, with rheumatic mitral valve stenosis underwent a percutaneous balloon valvotomy. Immediate results were good. By echocardiographic measurements, mean transmitral gradients went from 23.7 +/- 7.1 mmHg to 5.8 +/- 4.7 mmHg (p less than 0.001), diastolic pressure half-times went from 299.0 +/- 15.6 msec to 123.3 +/- 42.3 msec (p less than 0.001) and mitral valve areas measured by planimetry went from 1.00 +/- 0.15 cm2/1.73 m2 to 2.68 +/- 0.71 cm2/1.73 m2 (p less than 0.001). Hemodynamic measurements showed a decrease in mean pulmonary artery pressure from 48.3 +/- 13.2 mmHg to 32.5 +/- 5.7 mmHg (p less than 0.01), a decrease in the mean left atrial pressure from 26.1 +/- 6.3 mmHg to 14.6 +/- 4.7 mmHg (p less than 0.02) and an increase in calculated mitral valve area (Gorlin formula) from 1.07 +/- 0.31 cm2/1.73 m2 to 2.73 +/- 1.17 cm2/1.73 m2 (p less than 0.02). The only complication observed was a grade III mitral insufficiency in a child with marked subvalvular fibrosis. Six patients had a very good result and one kept a moderate mitral stenosis. Percutaneous balloon valvotomy gives probably better results in children than in adults and obtains at least as good results as surgical closed mitral commissurotomy. Presently, this technique is the treatment of choice for rheumatic mitral stenosis in children. Contra-indications are intra-atrial thrombus and shortened, thickened subvalvular apparatus.

Adolescent↗