[2 cases of persisting bilateral nasopalatine ducts].
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Biomedical subjects
Publications and source records attributed to H Lehmann.
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122 patients with urinary incontinence of all degrees and 32 controls are investigated by means of a complex urodynamic unit constructed by the authors. Essential part is a robust selfmade three-canal-catheter of heatsealed angiographic material with an external diameter of 10 Charr., which undamagedly can be used at least forty times. The unit enables to do cystometries and simultaneous cystourethrotonometries with electromyography of pelvic floor and mictiometries. The investigations are possible at a normal expense in lying or sitting and all intermediate positions. Many urometric parameters had been determined with aid of perfusion uromanometry according to the principle of Heidenreich and Beck. New combinations had been elaborated. The functional length of urethra in stress profile, the maximal urethral closing pressure, the electronically registered urethral closure pressure, the depression factor and the stress quotient are of special importance. By means of these criteria the qualification of the apparently old fashioned perfsuion uromanometry for a modern urodynamic diagnosis could be demonstrated. The results are compared with those obtained with microtransducer technique.
The perfusion urethrotonometry was used in this study in 34 patients both in lying and upright position as paired comparisons. The following problems could be solved: 1. Using the complex urodynamic unit of the authors examinations are possible in vertical position successfully. 2. The urethral pressure profiles are equivalent qualitatively in both examination positions. 3. The analysis of the profiles of both positions on principles demonstrates the same valuation. In case of incontinence the relevant parameters for diagnosis (functional length of urethra in stress profile, electronically registered urethral closure pressure in stressful situation, transmission and depression factor and stress quotient) show clearer in the upright position than in the lying one. In continent women the change of position has no significant influence. If the criteria in lying position are not well defined, the urethral pressure profile in upright position should be done as additional examination.
Freud's reaction to the death of his mother as he reported it in letters to Ernest Jones and Sandor Ferenczi is discussed. The sense of liberation and the absence of grief which he emphasized is given some analytic consideration. An attempt is then made to gain an understanding of Freud's somewhat cryptic remark that a change in the "values of life" in the "deeper layers" will have occurred following his mother's death. His discussion of these concepts in Civilization and Its Discontents, which was published just before her death, is utilized. The question is raised of whether the death of his mother may have been related to the change in Freud's view of the significance of the preoedipal mother which he presented in "Female Sexuality," the first paper he wrote after her death.
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A variant of haemoglobin A, named earlier haemoglobin Hijiyama, was found in three generations of a Finnish family in connection with the determination of glycosylated haemoglobin of a diabetic patient. The biochemical abnormality is in the beta-chain at residue 120 where lysine is replaced by glutamic acid. In the heterozygote carriers of the abnormal haemoglobin there was no apparent association with clinical or haematological abnormalities. By isoelectric focusing in thin-layer polyacrylamide gels, haemoglobin Hijiyama could be distinguished with high specificity from haemoglobin A as well as from other haemoglobin variants earlier found in Finland. The glycosylated haemoglobin fractions (haemoglobin A1 and haemoglobin Hijiyama 1) in the diabetic patient sample could be determined by colorimetric and electrophoretic methods.
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As a chronic, focal, necrotizing granulomatous angiitis Wegener's granulomatosis mainly affects the upper respiratory tract, the lungs and kidneys. Various other organs may be affected including te eyes. Ocular manifestation of Wegener's granulomatosis may result from granulomatous sinusitis that has proceeded into the orbit causing nasolacrimal duct obstruction and proptosis, and affecting eye muscles as well as the optic nerve. Another possible picture is presented by focal vasculitis in the form of conjunctivitis, episcleritis, scleritis, uveitis and granulomatous vasculitis of the retina and optic nerve. In 13 patients out of 26 examined the eyes were found to be involved. The etiology of Wegener's granulomatosis is unknown. The prognosis of this generally lethal disease could definitely be improved by early treatment with cyclophosphamide in combination with glucocorticosteroids.
A case of a 55-year-old man with the histological diagnosis rhabdomyosarcoma of the left pulmonary artery has been seen. Lung scanning and pulmonary arteriography are the clues for the diagnostical procedure. 55 cases from the literature are reviewed and clinical findings of the early and late stages of the diseases are discussed. Surgical treatment is the therapy of choice if ever possible; aggressive chemotherapy might be an acceptable alternative.
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Two siblings assumed on the basis of clinical and hematological evidence to have homozygous sickle cell (SS) disease were found to have a mother without sickle hemoglobin. Subsequent investigation and hemoglobin structural studies indicated the diagnosis to be sickle cell-Hb Lepore Boston syndrome. This syndrome generally manifests clinically significant sickle cell disease, and this genotype should be borne in mind in apparent SS disease where a parent without sickle hemoglobin in discovered.
The unusual association of alcoholic liver cirrhosis, atrophy of the left hepatic lobe and endophlebitis of the left hepatic vein (partial Budd-Chiari-Syndrome) has been observed in a 72-year-old male. The atrophy of the left hepatic lobe was diagnosed by liver scanning and laparoscopy. The patient's condition finally deteriorated and he died in a chronic form of hepatic coma. At autopsy the right hepatic vein, the branches of the portal vein and the extrahepatic bile ducts were normal. The left hepatic vein showed the histological picture of an organized endophlebitis of indeterminate age.
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