Search PubMed⌕ Search

Biomedical subjects

H Lechner

Publications and source records attributed to H Lechner.

At least 109 records · Page 6Linked to original sources
PubMed1983

Hemorheological effects of pentoxifylline on disturbed flow behavior of blood in patients with cerebrovascular insufficiency.

The influence of pentoxifylline (11-18 mg/kg orally, Trental 400) on impaired hemorheologic conditions has been investigated in a total of 73 patients with CVI. Throughout a treatment period of 4 weeks, there was a significant improvement in red cell behavior and a significant inhibition of increased platelet aggregation; moreover, a fall in plasma fibrinogen and of blood viscosity has also been observed.

Adenosine Diphosphate↗
PubMed1983

[Electroencephalographic and computer tomography findings in vascular epilepsy of ischemic origin].

143 patients with vascular epilepsy have been investigated, in whom generalised seizures were predominant (67%). 5% of the patients were younger than 30 years and 20% were between 30 and 50 years old. Pathological CT findings were seen in 78%. Focal lesions were most common particularly in patients with partial epileptic seizures as compared with those which had generalised seizures (p less than 0.05). In the EEG focal changes also dominated, but there was no significant difference in their occurrence with regard to patients with generalised or partial seizures. Epileptic potentials were observed in 17% of the patients with the emphasis on those with generalised epilepsies (p less than 0.05). Comparing EEG and CT in 69% of the patients concomitant pathological findings could be found. In patients with partial seizures there was a particularly good correlation between the focal changes in the EEG and lesions in the CT.

Adult↗
PubMed1983

[EEG in multi-infarcts with and without intellectual deterioration].

The character and extent of changes in EEG in 124 patients with multiple infarctions, verified by CT, were reported. Further, the EEG diagnoses of patients with (55) or without (50) accompanying dementia were compared. In 19 patients the evidence of dementia could not be defined clearly. The EEG-diagnoses in these patients were compared with a group consisting of 41 patients with primary degenerative dementia (Alzheimer). The EEG showed pathological results in 89 patients with multiple infarctions and focal abnormalities were dominant. In 55 patients with symptoms of dementia and multiple infarctions significantly more pathological EEG-reports were present than in the other patients with multiple-infarcts and a significantly slower basic rhythm could be found. In patients with neurological deficits as compared to the group without neurological symptoms and multiple infarctions the pathological changes dominated significantly. The comparison between patients with multi-infarct-dementia and 41 patients with a senile dementia of the Alzheimer type only revealed a more frequent occurrence of focal abnormalities in patients with multi-infarct-dementia. However there was no significant difference between the number of normal and pathological EEGs.

Adult↗
PubMed1983

Selective incorporation of fluorescein-labeled steroids in the vaginal epithelium of women of childbearing age.

The incorporation of fluorescein-labeled estradiol and desoxycorticosterone in human vaginal epithelial cells during the menstrual cycle was studied. The uptake of these steroids changes during the menstrual cycle and can be related to data on nuclear binding sites in the human endometrium during the menstrual cycle. Further studies must be done to prove the effectiveness of this method as a test for the hormone sensitivity of tissue or cells, especially the sensitivity of neoplastic tissue to hormonal therapy.

Adult↗
PubMed1982

A clinical approach to vascular (multiinfarct) dementia.

71 patients with an ischaemic stroke were investigated clinically, by psychological tests (WAIS) and Computertomography. On the basis of the investigation the patients were separated into two groups. 40 patients showed early dementia; 31 were without mental impairment. The frequency of strokes, the history of neurological symptoms and the neurological symptoms at admission were distributed evenly. The dominant hemisphere was significantly more often diseased in the demented group; bilateral signs were also significantly more often seen in the demented group. From the investigated risk factors (Hypertension, Cardiac disease, Diabetes, Viscosity, Fibrinogen). Only hypertension was significantly more often present in demented than non demented patients. The CT confirmed the clinical findings, especially the importance of the bilateral distribution of infarcts as well as a higher distribution of infarction in the thalamus in the demented patient group.

Brain Ischemia↗
PubMed1982

Computertomography in subarachnoid haemorrhage and aneurysm.

50 patients with SAH and an aneurysm were investigated by CT and angiography. In the 59 patients 67 aneurysms were found. The mean interval between SAH and CT was 8 days, between SAH and angiography II days. Blood in the CSF space was visualized up to the 9th day in the patients and 67% of those investigated showed blood in the CSF-space in the CT. In 31% of the patients an aneurysm, in 29% an intracerebral haemorrhage and in 19% a recent infarct was found. A hydrocephalus was seen in 13% of the patients. Of 12 patients with recent infarcts 8 showed vasospasm which correlated in time and location with the infarct.

Adolescent↗
PubMed1982

Clinical factors associated with dementia in ischaemic stroke.

71 patients with an ischaemic stroke were studied. The patients were separated into two groups on the basis of the results of clinical investigation, computed tomography and psychological testing (WAIS). 40 patients showed an early dementia and 31 were without mental impairment. The mean age was 57 years in the demented group and 54 years in the non-demented group. The mean duration of the history of cerebrovascular disease was also not statistically different in both groups. The frequency of strokes was identical since 50% of the patients in both groups had more than one stroke. The history of neurological symptoms together with the neurological deficits seen on admission were distributed evenly. The dominant hemisphere was more often diseased in the demented group. Bilateral symptoms were also more common in the demented stroke patients. The WAIS showed a similar IQ in both groups but the deterioration index was significantly altered in the demented group. Hypertension was the only risk factor which differed between both groups. Cardiac disease, diabetes, viscosity and fibrinogen did not differ in both groups. The CT showed more normal scans in the non-demented group, the distribution of atrophy on its own and infarction in the left or right hemisphere were both inconclusive, whilst patients with bilateral infarcts were more common in the dementia group. Also, generalised atrophy in combination with an infarct was found more often in the demented patients.

Brain Ischemia↗
PubMed1982

[The value of EEG in subarachnoidal haemorrhagia].

The EEG findings from patients with subarachnoidal haemorrhage are described. The results of the EEG and CT are compared. Furthermore the influence of neurological deficits on the number and degree of pathological EEG results was investigated and the EEG of patients with and without intracranial aneurysm, shown by angiography, were correlated. The EEG was pathological in 47 patients (70%) predominantly with focal changes. In the 17 patients with intracranial lesions pathological EEG records were significantly commoner and the changes were more evident. Also in patients with neurological deficits pathological EEG were significantly more frequent. In 25 patients with aneurysm, proved by angiography, predominately focal changes were found which gave us information about the site of the aneurysm. It was shown, that the EEG gives informations about intracerebral lesions and that in cases with subarachnoidal haemorrhage functional disturbances can be seen. The EEG is also of prognostic value.

Adolescent↗
PubMed1982

[Changes in pattern evoked visual potentials in multiple sclerosis in respect to development of illness].

In 43 patients (28 female, 15 male) with a definitive diagnosis of disseminated sclerosis visual evoked potentials were tested several times with pattern stimulation. The average duration of the disease was 7 years before the first pattern evoked potential. The latency of the evoked potential, estimated from the first positive peak, was in the pathological range in 30 patients in the first investigation, whereas in 38 patients there was a delayed latency in the last measurement. There was an average period of 1.5 years between the first and last investigation. In 20 cases the evoked potentials showed a continuous delay in the latency. Two patients maintained the original pathological values and in 7 cases the control results were below that of the first investigation. In 9 cases it was not possible to show a definite result because of the marked fluctuation in the values. 5 times in the entire investigation was a pathological result absent. There was a clear correlation between both the duration of the disease and the presence of a delayed latency, and the frequency of episodes and a pathological latency.

Adolescent↗
PubMed1982

[Night sleep studies: mobile recording in comparison to conventional laboratory recording].

Night sleep registrations were made in a group of 11 persons in a laboratory using both traditional polygraphic methods and a portable home recording system. A significantly higher value in the evaluation of the sleep efficiency index (quotient of total sleep time and total time in bed) was found with the mobile recording system. Apart from these findings the latency to the beginning of the particular sleep stages (classification of Dement and Kleitman) were diminished. Furthermore there was found a significant decrease of stage 1 in favour of the REM-sleep. Regarding the relation between the REM and the NREM-time, a distinct difference could also be shown. As to the subjective sensitivity, 10 of the 11 tested persons preferred the mobile recording system.

Adult↗
PubMed1982

[EEG night sleep recording: evaluation with automatic data analysis].

Sleep investigations were made in a laboratory using both traditional polygraphic methods and a portable home recording system (Medilog-Recorder 4-24). The evaluation was done by an automatic analysis. For the division into the particular sleep stages (classification of Dement and Kleitman) at least the diversions of 2 EEG and 1 EOG-channel were found to be necessary. As a further parameter the measurement of the pulse frequency was used. After the determination of the frequency-spectrum by the Fast Fourier Transformation a power spectrum was made in order to register the changes of voltages (in periods of 30 seconds) with a sample rate of 128 and a frequency resolution of 0.5 Hz. To evaluate the EOG, a band pass filter was used and after the determination of a level of 15 microV only activities over this value were regarded. Furthermore an automatic artifact detection was fit into the program. The activities of the EEG, the EOG and the pulse frequency were compared with the normal values of the stages and, after that, the particular sleep phases were determined.

Computers↗
PubMed1982

[Epidemiology, clinical aspects and long term prognosis of vascular (multiple infarct) dementia].

The frequency of dementia states in old age has been demonstrated and the increasing social medical importance has been focused upon. The discrepant frequency of dementia of cerebrovascular origin between the autopsy and clinical case material and the distinguishing characteristics to the primary degenerative (Alzheimer type) dementia as the most frequent form of dementia have been mentioned. The importance of clinical assessment, apparatus diagnosis and laboratory for the differential diagnosis have been discussed. The importance of the early diagnosis of an underlying vascular etiology for therapy with special attention to prophylactic viewpoints has been emphasized upon.

Aged↗