Search PubMed⌕ Search

Biomedical subjects

H Larsen

Publications and source records attributed to H Larsen.

At least 19 recordsLinked to original sources
PubMed1991

Mycoplasma hyosynoviae isolation from the upper respiratory tract and tonsils of pigs.

The occurrence of Mycoplasma hyosynoviae at different locations of the upper respiratory tract and tonsils of pigs was investigated in herds with problems of arthritis apparently caused by this microorganism. The isolation of M. hyosynoviae was facilitated by the use of a medium selectively suppressing the growth of Mycoplasma hyorhinis. M. hyosynoviae was cultured from 106 of 178 tonsils of slaughterhouse pigs from 8 herds but could not be isolated from the mucosa of the nasal cavity or the oral-pharyngeal area of 100 living, 10-20 weeks old pigs in 5 of the herds. The value of the selective principles in the medium appears from the circumstance that 86 of the 106 isolates were obtained despite the presence of M. hyorhinis. It is concluded that the tonsil is a reservoir for M. hyosynoviae and is probably the location of choice for an easy demonstration of the presence of this mycoplasma in a pig herd.

Animals↗
PubMed1989

Oxygen activation and defence against oxygen toxicity in a psychrophilic Bacteroidaceae.

When suddenly exposed to air the growth of the obligate anaerobic bacterium of the bacteroidaceae type, strain B6, continues for a few hours before coming to a complete stop. When air is shut off soon after growth has ceased, the organism is able to reestablish anaerobic conditions due to an ability to reduce O2, and resumes normal growth after another few hours. The O2 reducing ability of the organism is due to the presence in the cells of a particle-bound NADH oxidase, a soluble NADPH oxidase and a soluble pyruvate oxidase. The two pyridine nucleotide oxidases reduce O2 to H2O2, the pyruvate oxidase reduces O2 to H2O. Catalase and peroxidase were not detected in anaerobically grown cells. Kinetic studies with cell-free extracts showed that the pyruvate oxidase had a considerably greater affinity (smaller Km) for O2 and capacity (higher Vmax) for O2 reduction than the two other oxidases. It is postulated that the pyruvate oxidase acts as a scavenger for O2, leading to the non-toxic reduction product H2O, and thus functions as a defense mechanism against oxygen toxicity when the organism is exposed to aerobic condition.

Air Microbiology↗
PubMed1988

Excretion of mutagens in sweat from humans treated with anti-neoplastic drugs.

Base substitution mutagens were isolated and concentrated from sweat and urine of 7 patients treated with cyclophosphamide and other antineoplastic drugs. These samples were tested in Salmonella typhimurium TA 1535. The perspiration samples were collected under normal physiological conditions for 8 h after medication and urine samples were collected 8 h after medication. The perspiration samples from the patients were significantly more mutagenic than perspiration samples from the 7 control persons. No correlation was found between the mutagenicity of the perspiration samples and the urine samples.

Antineoplastic Agents↗
PubMed1987

Zuclopenthixol and perphenazine in patients with acute psychotic states. A double-blind multicentre study.

Fifty-four patients with acute psychotic states were included in a double-blind multicentre study of zuclopenthixol and perphenazine given orally. Fourteen patients had not received test preparations for a minimum of 3 weeks as stated in the protocol, and were excluded. The remaining 40 patients received the test preparations for 3 to 12 weeks, with an average of 49 days for patients receiving zuclopenthixol and 45 days for patients receiving perphenazine. Clinical evaluations were done at baseline and at weeks 1, 2, 4, 6, 8, and 12 including the CGI, a CPRS subscale for schizophrenia, and the UKU Side Effects Rating Scale. The patients received on average 37 mg zuclopenthixol or 30 mg perphenazine daily. Statistically, significant reductions on the CGI, severity of illness, and on the CPRS (total score) were found for both drugs when comparing baseline with later scores. No significant differences between the drugs were found. It was also impossible to demonstrate a difference in clinical profile between the two drugs on the basis of the single items on the CPRS. Although small differences between the two drugs were found, as regards number and type of side effects, it is concluded that the pattern of side effects was almost identical in the two treatment groups.

Clopenthixol↗
PubMed1987

Stress-tension reduction in the treatment of sexually tortured women--an exploratory study.

Three women who had been tortured and sexually abused during imprisonment as political prisoners during the dictatorship in the Philippines were treated with a nonverbal, manual stress-tension reduction therapy (STRT). All women had difficulty in sexual and social relationships and a series of unspecific complaints such as headache, dizziness, irritability, aggressiveness toward their own children, etc. The therapy is described. A series of four sessions was given each woman, followed by group training. A remarkable improvement was noted, and it is suggested that STRT may be use in other sexological disorders.

Adult↗
PubMed1979

Trimethylamine oxide: a terminal electron acceptor in anaerobic respiration of bacteria.

Trimethylamine oxide (TMAO) stimulated both the anaerobic growth rate and the growth yield of Proteus NTHC 153. The molar growth yield from glucose and pyruvate in tryptone/yeast extract medium doubled in the presence of TMAO, and the organism grew anaerobically on the non-fermentable substrates L-lactate and formate when TMAO was added to the medium. We conclude that TMAO stimulated growth by serving as a terminal electron acceptor in an oxidative phosphorylation process.

Anaerobiosis↗
PubMed1979

Interrelationships between skeletal muscle adaptations and performance as studied by detraining and retraining.

The effects of 15 days of detraining and 15 days of retraining were studied in 6 well-trained runners. Detraining resulted in significant decreases in the mean activities of succinate dehydrogenase (SDH) and lactate dehydrogenase (LDH) of 24% and 13% respectively, but no significant increases in these enzymes activities occured with retraining. Maximal oxygen uptake (VO2 max) decreased by 4% with detraining (p less than 0.05), and increased by a similar amount with retraining. Performance time in an intense submaximal run decreased by 25% (p less than 0.05) with inactivity, but still averaged 9% below the initial level after retraining. Maximal heart rate and peak heart rate during the performance run were higher after detraining by 4 and 9 beats per min, respectively (p less than 0.05). With retraining, these heart rate values were decreased by 7 and 9 beats per min (p less than 0.05). Blood lactate concentrations after the VO2 max and performance run were approximately 20% lower after detraining and retraining (p less than 0.05). Muscle fibre areas for three subjects tended to be larger in biopsy samples taken after detraining and retraining. These data suggest that even short periods of detraining result in significant changes in indices of physiological capacity and function in subjects near their upper limit of adaptation, and that a longer period of retraining is necessary for muscle to re-adapt to its original trained state.

Adaptation, Physiological↗
PubMed1979

Evaluation of tcPO2, beat-to-beat heart rate and respiration in neonates with episodes of cyanosis, bradycardia, or apnea.

Episodes of cyanosis, bradycardia, or apnea were studied in 26 newborns and prematures by continuous recording of tcPO2, beat-to-beat heart rate, and impedance pneumography. Hypoxemia related to therapeutic, diagnostic, or care procedures is very common and often is not accompanied by bradycardia or apnea. Idiopathic bradycardia lasting less than 30 seconds will not lead to hypoxemia. However, idiopathic bradycardia of more than 30 seconds' duration can lead to hypoxemia. Beat-to-beat cardiograms and transcutaneous oxygen measurement appear to be the most reliable methods for routine monitoring of these patients.

Apnea↗