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Biomedical subjects

H Landgraf

Publications and source records attributed to H Landgraf.

71 records · Page 4Linked to original sources
PubMed1976

Comparative tests on safety and potency of IBA vaccines.

During a comparative test on the pathogenicity and immunogenicity of a non-adapted and an embryo-adapted IDA virus, following observations were made: 1) the non-adapted virus remained pathogenic as determined by weight loss and bursal lesions. Clinical signs and mortality did not occur. A change in the virulence did not occur during back passages; 2) the immunosuppressive effect of the non-adapted virus was diminished by maternal antibodies; 3) the embryo-adapted virus produced little pathogenicity as demonstrated by minor weight depressions. The vaccinated birds had no recognizable pathological lesions in the bursae. Immunosuppression with this virus was not observed; 4) the embryo-adapted strain was able to induce neutralizing antibodies in birds with or without maternal antibodies. However, precipitins were not detected; 5) immunization with the embryo-adapted strain after 8 days of age was protective whereas prior to that age it was not confirming the age susceptibility factor reported by Hitchner (1971); 6) no change in virulence occurred during back passages with both test materials.

Administration, Oral↗
PubMed1975

[Osmo-oncotherapy in brain edema].

The treatment of cerebral edema must be directed towards improving the volume regulation of the brain cell which is disturbed due to reduced blood flow and hypoxia and towards restoring the disturbed function of the blood-brain barrier. Onco-osmotherapy increases the effective intracranial blood pressure difference and improves cerebral blood supply and oxygen absorption, thus exerting a positive effect on sodium concentration in the brain cell which is responsible for the intracellular corticocerebral edema. After renal excretion of the osmotherapeutic agent, however, water may again flow into the brain cell, depending on the osmotic gradient. When the function of the blood-brain barrier is disturbed, osmotherapy may lead to an undesired increase of the osmotic pressure in the tissue. In spite of this, onco-osmotherapy is one of the most effective measures in the treatment of cerebral edema. Choice of therapeutic agents, dosage, infusion rates, side effects and contraindications are dealt with in detail.

Biological Transport↗
PubMedDate not supplied

In vivo rheologic effects of lipid apheresis techniques: comparison of dextran sulfate LDL adsorption and heparin induced LDL precipitation.

The effects of two different LDL apheresis techniques, heparin-induced LDL precipitation (HELP) and dextran sulfate LDL adsorption (DSA), were compared in six patients with familial hypercholesterolemia. Total and LDL cholesterol were effectively lowered with both techniques. The reduction of serum triglycerides was more pronounced with DSA, whereas the reduction of HDL cholesterol was more pronounced with HELP. Single sessions using both techniques immediately reduced whole blood and plasma viscosity, as well as erythrocyte aggregation. Serum fibrinogen decreased by 62% (HELP) and 11% (DSA). Maintenance lipid apheresis administered 1 time per week resulted in a sustained reduction of total and LDL cholesterol and was associated with a sustained improvement in blood flow properties. Data suggest that besides serum fibrinogen, serum lipoproteins may adversely effect the rheologic characteristics of blood.

Adsorption↗
PubMedDate not supplied

Effect of erythropoietin treatment on tissue oxygenation in patients with severe transfusion dependent renal anaemia.

OBJECTIVES: Severe renal anaemia can now be effectively treated with recombinant human erythropoietin (rhEpo). To evaluate muscle tissue oxygenation in patients with severe renal anaemia and the effects of an rhEpo treatment, muscle tissue oxygen tensions were measured in 9 patients suffering from end stage renal disease with severe renal anaemia before and during rhEpo treatment. METHODS: Muscle tissue oxygen pressure (method according to Ehrly and Schroeder), transcutaneous oxygen pressure (tcpO2) (Radiometer, Copenhagen), haematocrit (micro haematocrit method), plasma viscosity (Ostwald capillary viscometer) and erythrocyte aggregation (method according to Ehrly and Schmitt) were determined before as well as 4, 8, and 24 weeks after onset of treatment with 80 U/kg body weight 3 times per week. RESULTS: Muscle tissue pO2 values before treatment were markedly diminished when compared with normals and showed a marked increase into the normal range parallel to the increase in haematocrit. tcpO2 values were in the upper normal range before treatment and did not show significant changes during treatment. Erythrocyte aggregation and plasma viscosity did also not show significant changes. CONCLUSION: During rhEpo treatment a marked increase of muscle tissue pO2 can be found. This increase may be one of the mechanisms responsible for the improved well being and physical exercise tolerance in these patients due to erythropoietin treatment.

Adult↗