Search PubMed⌕ Search

Biomedical subjects

H L Spohr

Publications and source records attributed to H L Spohr.

25 records · Page 2Linked to original sources
PubMed1982

Development of psychopathology of children with the fetal alcohol syndrome.

Extended psychiatric and pediatric examinations were performed on patients with the fetal alcohol syndrome (FAS). A subgroup of these patients underwent psychological testing to measure intelligence, visual perception, and psycholinguistic abilities. Psychopathology was also studied in a matched control group. The investigation revealed a broad scale of developmental hazards and psychopathologic symptoms indicating the negative long-range effects of alcohol abuse during pregnancy. The extent of morphologic damage was found to be a good predictor of psychopathology and mental impairment. Social environment and socioeconomic status appear less important as predictors.

Adolescent↗
PubMed1982

Steroid treatment of pseudo-croup.

In a randomized, controlled investigation, 349 children with pseudo-croup stage I or II were given 6 mg of dexamethasone or placebo. Although the rate of recovery was similar in both groups, there was a significant difference when only the more seriously affected children were considered: steroid treated patients recovered quicker. Steroids appear to be useful in the routine treatment of simple, uncomplicated pseudo-croup, even if their effect apparently is not very impressive. Thus, close supervision remains the most important measure in this nearly always benign but potentially dangerous condition.

Acute Disease↗
PubMed1982

Development and psychopathology of children with the fetal alcohol syndrome.

Extended psychiatric and pediatric examinations were performed on patients with the fetal alcohol syndrome (FAS). A subgroup of these patients underwent psychological testing to measure intelligence, visual perception, and psycholinguistic abilities. Psychopathology was also studied in a matched control group. The investigation revealed a broad scale of developmental hazards and psychopathologic symptoms indicating the negative long-range effects of alcohol abuse during pregnancy. The extent of morphologic damage was found to be a good predictor of psychopathology and mental impairment. Social environment and socioeconomic status appear less important as predictors.

Abnormalities, Drug-Induced↗
PubMed1981

[Reye's syndrome (author's transl)].

After a viral infection (Coxsackie-A-9) a twelve-year-old boy developed symptoms of acute encephalopathy and fatty degeneration of the liver. A fatal outcome could not be averted. Clinical course, laboratory data, light and electron microscopic examinations were typical for Reye's syndrome, a rare diagnosis in Central Europe.

Adolescent↗
PubMed1981

[Studies on alcohol embryopathy (author's transl)].

Data from pediatric, neurological, psychiatric and psychological examinations of 71 children suffering from alcoholembryopathy (AE) are reported. In comparison to a matched control group history revealed an increased rate of developmental retardation during the neonatal period and the toddler age. Besides the frequently described morphological characteristics neurological examinations frequently revealed deficits of fine motor coordination. Psychiatric examinations led to various symptoms indicating a marked psychoorganic syndrome. Impairment of cognitive functions was detected by psychological testing. Finally there were positive correlations between morphological and psychological damage.

Child↗
PubMedDate not supplied

Therapy of infantile spasms with valproate: results of a prospective study.

In a prospective study, 22 children with recently manifested infantile spasms (18 patients with symptomatic and 4 with idiopathic infantile spasms) were treated with sodium valproate (VPA). Before VPA was instituted, a loading test was performed to exclude abnormal patterns of VPA metabolites by gas chromatography and mass spectroscopy of serum and urine. This test was repeated during VPA therapy; an abnormal pattern of VPA metabolites was not observed. VPA was started in increasing dosage until infantile spasms were controlled or a maximum dose of 100 mg/kg/day was reached. If VPA did not control seizures or at least reduce frequency significantly after a trial of 4-6 weeks, dexamathasone was added to VPA. If focal seizures occurred in association with localized epileptogenic EEG discharges, carbamazepine (CBZ) was added to VPA. After 4 weeks of VPA monotherapy, infantile spasms were controlled in 11 children. After 3 months of therapy, 16 children were free of seizures (14 patients VPA monotherapy), and 4 children had reduction of seizure frequency to less than 25%. VPA doses varied between 40 and 100 mg/kg/day (mean 74). The mean plasma concentration was 113 micrograms/ml (range 46-177). After 6 months of therapy, total seizure control was achieved in 20 of 22 patients (16 children VPA monotherapy). The mean observation time was 16 1/2 months (range 6-36 months). There were seven relapses in six children during the first 7 months of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adrenocorticotropic Hormone↗