Antibody responses of young infants to naturally occurring viral infections.
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Adenoviridae Infections↗
Biomedical subjects
H L Moffet
Publications and source records attributed to H L Moffet.
Micro diffusion precipitin tests for enteroviruses and influenza B virus.
Middleton, G. K., Jr. (Bowman Gray School of Medicine, Winston-Salem, N.C.), H. G. Cramblett, H. L. Moffet, J. P. Black, and H. Shulenberger. Micro diffusion precipitin tests for enteroviruses and influenza B virus. J. Bacteriol. 87:1171-1176. 1964.-A simple micro precipitin gel diffusion test has been adapted to the study of viral antigens. As far as is known from a review of recent literature, this is the first use of the ECHO viruses in precipitin tests and the first attempt to demonstrate by the gel diffusion technique precipitins in a patient's serum after natural virus infection rather than artificial immunization. The principal value of this technique in virology is the rapid identification or qualitative analysis of viral antigen preparations by use of pooled or specific hyperimmune sera. Virus concentrations of 10(7)tcid(50) per 0.1 ml are required for reliable results, but only 0.015 ml of serum is necessary for each test. Virus-serum precipitin reactions were type-specific except for reciprocal precipitation of ECHO 1 and ECHO 8 by their hyperimmune sera. No viral antigens have been found common to two or more virus types among those tested. Precipitins for viral antigens occur frequently in serum of patients after a viral infection and are readily detected by micro precipitin gel diffusion tests. However, this precipitin test remains at present a tool for virus and antigen identification and offers an approach for research appraisal of host response to infections.
Animals↗
Pediatric nosocomial infections in the community hospital.
This review focuses on the pediatric nosocomial problems of the past few years, with emphasis on those found in community hospitals. The nosocomial infection problem of congenital rubella syndrome, genital herpes exposures, diarrhea, common childhood diseases and major lower respiratory infections are emphasized. Opinions about current problems are stated with the recognition that further scientific observations will lead to new recommendations.
Bacterial Infections↗