Search PubMed⌕ Search

Biomedical subjects

H L Atkins

Publications and source records attributed to H L Atkins.

At least 127 records · Page 7Linked to original sources
PubMed1975

Quinoline analog labeled with iodine 123 in melanoma detection.

Using the Greene melanoma in the hamster (Syrian Golden), the radiopharmaceutical, 123-1-4(3-dimethylaminopropylamino)-7-Iodoquinoline, was tested for its ability to localize melanoma. This quinoline analog has been described for use in the detection of melanoma, but this is the first report, to our knowledge, of its being used with an 123-l label. Hamsters with either skin or eye melanomas were studied. Both melanomas could be seen with a gamma camera at three hours after injection. In vitro analysis confirmed the tumor specificity. Thus, it appears that this preclinical trial of a new radiopharmaceutical justifies clinical testing to determine its value in the localization of melanomas of the eyes and skin of humans.

Administration, Oral↗
PubMed1975

Effect of absorption edge filters on diagnostic x-ray spectra.

The spectra of diagnostic x-ray beams were measured with a germanium semiconductor dectector. With this system it was possible to define the K-alpha-1, K-alpha-2, K-beta-2 characteristic peaks of the tungsten target. The effects of various filters on the beam using characteristic absorption edges to create a "bandpass" effect were studied. Gadolinium filtration of the diagnostic beam used for contrast studies selectively removed both higher energy photons (greater than 50 keV) and lower energy photons (less than 33 keV) thus enhancing contst for iodine and barium while substantially reducing radiation dose.

Aluminum↗
PubMed1975

Distribution of various labeled thioglucoses in rodents.

Gold, silver and lead thioglucose were evaluated in rodents to determine the value of organo-metallic compounds in the study of metabolic abnormalities. Increased radioactivity concentration was noted in the hypothalamus with all compounds. Gold thioglucose concentrated in the kidneys and thymus, and 203Pb-thioglucose concentrated in the pancreas and thymus.

Adrenal Glands↗
PubMed1975

Thallium-201 for medical use. I.

Thallium-201 merits evaluation for myocardial visualization, kidney studies, and tumor diagnosis because of its physical and biologic properties. A method is described for preparation of this radiopharmaceutical for human use. A critical evaluation of 201Tl and other radiopharmaceuticals for myocardial visualization is given.

Cesium Isotopes↗
PubMed1975

Thallium-201 for medical use. II: Biologic behavior.

Thallium-201 has been evaluated for myocardial imaging by determining its distribution and assessing its imaging properties. Organ distribution with time was studied in goats, chosen for their large size and easy operability. Myocardial imaging was performed in living and sacrificed goats and also in two anesthetized dogs, without infarction. Infarcts were made by ligature at open chest surgery on the goats and the infarcts subsequently confirmed histologically. The myocardium of normal and infarced, young and old goats was cut into blocks and the isotope distribution measured and compared with that in the lungs, liver, spleen, and kidney in normal goats. The renal medulla-to-cortex concentration ratio in goats was studied and is approximately five. The heart uptake exceeds 3% for 100 min whereas contiguous organs have less than one-half of the myocardial concentration, and blood clearance is rapid. One problem may prove to be inhomogeneity of uptake of thallium in the "normal" myocardium, showing a standard deviation of 1u% in a young goat and 29% in an old goat. In view of the good myocardial uptake, however, this work strongly suggests the trial 201Tl in patients.

Animals↗
PubMed1975

Localization of radioactive lead in ocular and skin melanoma.

The ability of radioactive lead to localize melanomas was studied. The Greene melanoma in the Syrian Golden hamster served as a model for both skin and ocular melanoma. The affinity of heavy metals for neoplasms has been studied but previous reports have been inconsistent as to tumor specificity. For this investigation the radioactive lead (203-Pb,) was studied as the chemical complex 203-Pb-Tris. Significant tumor:nontumor ratios were found in ocular melanoma and the concentration in the lens was minimal. The ratio of per cent uptake per gram of tumor: per cent uptake per gram in control tissue with skin melanoma was 9.4 at 24 hours and for the eye melanoma the ratio was 26.3 at 24 hours. The affinity of 203-Pb-Tris for melanomas appears to be as promising as other compounds presently being evaluated for ocular scintigraphy, namely, labeled quinoline analogs. Therefore, further preclinical evaluation is warranted.

Animals↗
PubMed1973

Closing volume.

Explore the source record for details and available documents.

Adolescent↗