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Biomedical subjects

H Kyank

Publications and source records attributed to H Kyank.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Contribution towards diagnostics of intrauterine fetal retardation (author's transl)].

1. Among the simple manual methods for recording intrauterine retardation repeated measurements of the symphysis-fundus distance according to Westin are most valuable. -- 2. Among the hormone-determining methods the estimation of urinary estrogens or unconjugated estriol in serum is generally accepted. -- 2. Estimations of enzymes are of no value (diamine oxidase, alkaline leukocyte phosphatase, heat stable alkaline phosphatase) or have only little significance (cystine aminopeptidase). -- 4. Biochemical methods are being replaced to an increasing extent by biophysical ones both for recording fetal retardation by ultrasonics and fetal well-being by CTG, non-stress test, oxytocin-challenge test and, recently, by registration of fetal breathing and rump movements. -- 5. As a provisional method for evaluation of fetal behaviour the counting of fetal movements by the pregnant women herself can be recommended.

Clinical Enzyme Tests↗
PubMed1980

[Surgical treatment of cervical carcinoma (author's transl)].

At the Gynaecological Hospital of Rostock University radical abdominal surgery was performed on 321 cases of cervical carcinoma and radical vaginal surgery on 268 cases, between 1950 and 1972. The five-year survival rates were 73.5 or 83.8 per cent, respectively. Indications as well as morbidity and lethality of either approach are discussed, and the authors' personal experience is reported. - The value of lymphography has remained to be disputed. Reasons are given for general renunciation of presurgical irradiation and for sole use of radiological techniques and their limited applicability in postsurgical treatment.

Adult↗
PubMed1979

Extraamniotic intermittent administration of prostaglandin F2 alpha during the first and second trimesters of pregnancy.

Extraamniotic application of prostaglandin F2 alpha (PGF2 alpha) was used for legal abortion in the series of 1012 women. The pregnancies were terminated by abortion between the 6th and 27th weeks of pregnancy. In 86.7% of the cases, intermittent extraamniotic application of PGF2 alpha led to complete or incomplete abortions. Of the 26 failures, nine were caused by technical difficulties. In 17 primigravidae, the cervical canal remained closed. There were no statistically related differences between the different weeks of the pregnancy with regard to success and failure rates. The mean PGF2 alpha dose and abortion time increased significantly (p less than 0.01) with increasing duration of pregnancy. 80% of the patients suffered from undesirable side effects. The morbidity rate for the period up to six weeks following the abortion was 3.2%.

Abortion, Incomplete↗
PubMed1978

[Pros and cons in the therapy of hypertensive gestoses. I. Pre-eclampsia and eclampsia].

The authors report on the modern trends and the pro and contra in treatment of pre-eclampsia and eclampsia. Ambulatory therapy is only allowed in mild preeclampsia by rest, high-protein lowcaloric diet and mild sedation. Also during the stationary therapy diuretics should be commonly avoided. As sedative drugs magnesium sulfate, diazepam, clomethiazole and barbiturates are recommended. Antihypertensive drugs are given when the blood pressure exceeds 180/110 mm Hg. Favoured drugs are hydralazine, methyldopa and beta adrenergic substances. For the treatment of eclampsia well tried standardized methods with few drugs as magnesium sulfate and when necessary barbiturates and hydralazine are mentioned, furthermore, the combination with new therapeutic managements as the osmo onco-therapy and the modern anaesthetic technics. There is agreement that in severe preeclampsia induction of labor should be performed before term. The indication for that is facilitated by the modern perinatal diagnostics.

Antihypertensive Agents↗
PubMed1978

[Pros and cons in the therapy of hypertensive gestoses. II. Chronic hypertension].

The authors discuss some controversial aspects of the therapy of chronic hypertension in pregnancy. In cases in whom the blood pressure has been treated before conception the therapy should be continued. But there is no agreement about beginning of the hypotensive therapy during pregnancy. Some authors recommend an early treatment, others give hypotensive drugs only for those women who show no fall of the blood pressure in the second trimester or when the blood pressure exceeds 170/110 mm. Hg. These controversial opinions result from our defective notice of the uteroplacental blood flow during a long-continued application of antihypertensive drugs and their dose-response. As hypotensive agents methyldopa, hydralazine and beta adrenergic substances are recommended, on part of internists also medicaments which are used in nonpregnant patients. In severe chronic hypertension premature induction of labor is necessary. In hypertension III degree and IV degree the pregnancy should be interrupted.

Abortion, Therapeutic↗
PubMed1977

[Studies on the binding capacity of thyroxin-binding globulin (TBC), total thyroxin (T4), free thyroxin index (FT4-I) and the ETR-test in gestosis and placental insufficiency].

Total serum thyroxine (T4), thyroxine binding capacity (TBC), free thyroxine index (FT4-I) and effective thyroxine ratio (ETR) were measured in 53 toxemias of pregnancy and in 5 cases with placental insufficiency. Total serum thyroxine, ETR and FT4-I were found in physiological ranges of the normal pregnancy, the TBC-index was decreased. Between the 19. and 34. week of pregnancy, the decrease of the TBC-index was smaller than after the 34. week of pregnancy.

Adult↗
PubMed1977

[Normal standards for birth weight and birth length of newborns in the DDR].

Normal anthropometric standards of birth weight and birth length are presented for newborn boys and girls in the GDR between 28 and 44 weeks' gestational age. Newborns with uncertain duration of gestation, multiple births, malformations and stillbirths have been excluded. It is directed to necessity of regional standards.

Anthropology, Physical↗
PubMed1976

[Behavior of serum alkaline during pregnancy. II. Pathological pregnancy].

832 estimations of heat stable alkaline phosphatase (HSAP) and of heat alkaline phosphatase (HLAP) were carried out simultaneously in late pregnant women at 25th to the 42nd weeks of pregnancy. 147 of them delivered children with normal birth-weight. All these women suffered from pre-eclampsia, hypertension or any kind of superimposed pre-eclampsia. 110 other pregnant women with or without symptoms of pre-eclampsia gave birth to small for dates babies. In addition, the values of these patients were compared with 372 estimations of the same enzymes carried out in 120 patients with normal pregnancy and outcome of normal weighted children. The site of the values of every group showed no typical correlation to the course and outcome of their pregnancy. Regarding four special criterions it was possible to give a good prediction by serial determinations for the weight of the newborn in 80 per cent of the cases. A correlation between the urinary excretion of total oestrogens as well as HLAP and the values of HSAP was to be found only in some groups of patients.

Alkaline Phosphatase↗
PubMed1976

[A critical review of hypothetical causes of EPH-gestosis].

The essential EPH-gestosis seems to have multiple aetiological factors and the disease develops already a long time before the appearance of the classical symptoms. The disturbed renal function is the main point among secondary pathological effects as the damaged placenta, the disseminated coagulation, the glomerular endotheliosis, the increased retention of water and sodium with increased arterial responsiveness. It may be that this reduced reversible renal function is of extra-renal origin. As predisposing factors were discussed the reduced uteroplacental circulation with the release of still unknown pressor substances or decreased inactivation of pressor amines, the uterorenal reflex mechanism, the disturbed homeostasis of the body fluids and the vegetativ-hypothalamic crisis etc. But other factors may also be participate on this disease as immunological and hormonal aspects, especially the renin-angiotensin-aldosteron-system and prostaglandins. To find out the aetiological factors we should examine the disease at the beginning in comparison with normal pregnancy. These factors must explain why the true EPH-gestosis appears mainly during the first pregnancy and frequently in twins and so on.

Aldosterone↗
PubMed1975

[Results of standard-value determinations in newborn infants in the German Democratic Republic. II. Head circumference, biparietal and fronto-occipital diameter].

Using the measurements taken from 6645 male and 6381 female newborns from the GDR-population the normal values from head circumference, fronto-occipital and biparietal diameter are reported. The results were given in relation to duration of pregnancy (31. to 44. week of pregnancy) expressed in percentile tables. Head circumference and fronto-occipital diameter were larger in males than in females. The head circumference values are compared directly and in their relation to birth weight and length with the data reported by other authors.

Cephalometry↗
PubMed1975

[Immunological aspects in EPH gestosis].

On the base of the fundamental knowledge on immunological reactions in the normal pregnancy the disease of the EPH-gestosis is described from the immunological viewpoint. The following facts may be significant: 1. The increased occurence of specific and nonspecific crossreacting antibodies against liver, kidney and placental tissue in the blood of pregnant women and puerperas. 2. The increased occurence of placental infarctions and throphoblastic defects as well as fibrinoid deposits in the placenta, the arteriols and in the kidney. 3. Changes in the protein composition of blood. 4. The changed maternal cell-mediated immunity.

Alkaline Phosphatase↗
PubMed1975

[Behavior of alkaline phosphatase in serum during pregnancy. I. Normal pregnancy].

On 120 patients, during normal pregnancy, from the 17th to the 42nd week of pregnancy, 372 heat labile alkaline phosphatase estimations were carried out by means of the 4-nitrophenol method. In addition to that, after incubation of sera at 65 degrees C for 30 minutes, the activity of the heat stable placental isoenzyme was checked. With progressing pregnancy, the heat stable fraction rises significantly and the heat labile fraction of total alkaline phosphatase increases slightly. There is a correlation between the readings of the two fractions. In 169 cases, the total urinary oestrogen output correlates also with the heat stable alkaline phosphatase.

Alkaline Phosphatase↗
PubMed1975

[Changes in the binding capacity of thyroxine-binding globulin (TBC), of total thyroxine (T4), of the free thyroxine index (FT4-I) and of thyrotropin (TSH) during normal pregnancy and in hydatidiform mole].

TBC-index and total serum thyroxine were measured in 100 healthy nonpregnant and in 163 pregnant women during the 8. and 41. weeks of gestation. The free thyroxine index was calculated. The TBC-index was found to be elevated in pregnant women and rose continously with duration of pregnancy. The amount of total serum thyroxine was greater in pregnant women (p less than 0,01) without difference between early and late pregnancy. The free thyroxine index decreased continously during pregnancy (p less than 0,01). Serum TSH level were elevated during the first two trimesters of pregnancy. At the third trimester the TSH level were found within the normal range. In patients with hydatidiform mole TSH, total thyroxine, FT4-index, ETR-index as well as TSH levels were increased.

Adult↗