Search PubMed⌕ Search

Biomedical subjects

H Kuroda

Publications and source records attributed to H Kuroda.

At least 271 records · Page 15Linked to original sources
PubMed1988

Sarcoidosis with multiple calcification.

Sarcoidosis, having a twenty-nine years of clinical course, associated with multiple calcified deposits in neck, mediastinum, liver, spleen, kidney, abdominal lymphnodes and lung was reported. Calcified opacity, which was firstly detected during initial two years on plain chest and abdominal x-ray films, increased in calcified mass insidiously. Though, the examination on this admission failed to reveal pathogenesis of multiple calcification, immunological derangement seemed to initiate and promote the calcification.

Calcinosis↗
PubMed1988

In vivo effects of deoxyspergualin (NKT-01) on lymphocyte activation in response to alloantigens.

We studied the effects of deoxyspergualin (NKT-01) on the events of lymphocyte activation in vivo by inoculating mice in the footpad with allogeneic spleen cells, and compared the effects with those of cyclosporin A (CyA). The administration of NKT-01 increased the numbers of cells recovered from the popliteal lymph node (PLN) 7 days after inoculation, but inhibited the proliferation of these cells in the presence of exogenous interleukin 2 (IL-2). NKT-01 enhanced IL-2 production, but suppressed the production of macrophage activating factor (MAF) in the mixed lymphocyte reaction between the PLN cells and allogeneic spleen cells treated with mitomycin C. CyA decreased the numbers of PLN cells little, and suppressed the response to exogenous IL-2 and the production of both IL-2 and MAF. Results with tumor cells used as allogeneic cells suggested that there was a close relationship between the suppression of MAF production by NKT-01 and its inhibition of allograft rejection. The findings showed that NKT-01 inhibited both the MAF production by and the response to IL-2 of PLN cells, and that these effects were involved in the suppression of allograft rejection by NKT-01.

Animals↗
PubMed1988

Feedback analysis of the behavior of the renin-angiotensin system under inhibition of angiotensin-converting enzyme.

It was previously shown that autoregressive modeling can be used for feedback analysis in the body. We used this method to investigate the dynamic changes in and around the renin-angiotensin system in vivo induced by angiotensin-converting enzyme (ACE) inhibition. Long-term studies were performed on rabbits, which were given a daily injection of one of the following ACE inhibitors: captopril, foroxymithine, or histargin. For comparison, other rabbits received injections of saline or the renin inhibitor pepstatin. Autoregressive coefficients were computed from the raw data thus observed and were used to simulate the impulse-response function proper to each animal. The response of each animal estimated in this way exposed the effects of ACE inhibitors in vivo which were obscured by the feedback regulation of the renin-angiotensin system. Also, it was suggested that histargin has a peculiar action, blocking the negative feedback that would be elicited by the usual ACE inhibition. Feedback analysis seems to be essential to elucidate the in vivo effects of enzyme inhibitors.

Angiotensin-Converting Enzyme Inhibitors↗
PubMed1987

A case of four coronary artery fistulae originating from three vessels associated with aneurysm.

A case of an aneurysm associated with four coronary artery fistulae originating from three vessels is reported. The patient, a 52-year-old woman, had chest heaviness and palpitations. Coronary arteriography revealed the four fistulae originating from three coronary vessels with an aneurysm draining into the left ventricle and the main pulmonary artery. The patient's symptoms were relieved after fistulectomy and the aneurysmectomy, suggesting that a coronary steal phenomenon through the fistulae was the cause of her symptoms. This case is of interest because of its rarity, since this is the first case report of an aneurysm associated with four coronary artery fistulae from three vessels.

Arterio-Arterial Fistula↗
PubMed1987

A case of postganglionic cholinergic dysautonomia.

A 24 year old female presented with signs and symptoms of postganglionic cholinergic autonomic dysfunction manifested by impaired lachrymation and salivation, mydriasis of the pupil, decreased gastrointestinal motility, atony of the bladder, and sweating and taste disturbance. Clinical and pharmacological studies confirmed that the abnormalities were restricted mainly to the postganglionic cholinergic autonomic systems. The titre of serum complement was low, antinuclear antibodies revealed a diffuse pattern, and anti SS-A antibody was positive, suggesting that this disorder was caused by an immune mechanism.

Adult↗
PubMed1987

Foreign particles contaminating hemodialyzers and methods of removing them by rinsing.

Foreign particles contaminating hemodialyzers constitute a risk of microembolism and allergic reactions in hemodialysis patients. We investigated the size distribution of particles, and the effects of striking headers of dialyzers and flow rates of rinsing saline on the elimination of foreign particles from dialyzers. Saline used for rinsing was filtered through a Millipore filter, and the particles thus removed were observed microscopically. We also checked changes in particle counts in a closed circuit consisting of a dialyzer and blood lines during 5 h of continuous circulation with a blood pump. The number of contaminating particles increased exponentially as their size decreased. For the sake of reproducibility we counted particles having diameters larger than 3.0 micron to monitor the rinsing efficiency. During rinsing, particles in the dialyzer were effectively eliminated by striking the headers of the dialyzer. We found that striking should be started immediately after the blood line is filled with saline, and that variation in saline flow rates in the range of 350-700 ml/min of saline does not affect the rinsing efficiency. By filtration of saline used for rinsing, particles, mostly ranging from 5 to 200 micron in length, of many shapes and colors were found. Among them were fibers having a length of as much as a few millimeters. Once dialyzers were rinsed effectively, there was almost no change in particle counts in a closed circuit consisting of a dialyzer and blood lines. To rinse dialyzers effectively, at least 1,000 ml of saline are necessary, and striking the headers of dialyzers throughout the rinsing procedure is important.

Equipment Contamination↗