Biomedical subjects

H Kuratsune

Publications and source records attributed to H Kuratsune.

39 records · Page 3Linked to original sources

PubMed1983

A simplified method for detecting macroamylasemia by measuring serum amylase activity at different reaction temperatures.

Amylase activity in serum and urine, and isoamylase, were measured in 300 patients with abdominal pain to detect cases of macroamylasemia. Of these patients, 9 had hyperamylasemia and 2 were diagnosed as cases of macroamylasemia on the basis of their amylase/creatinine clearance ratio, the gel filtration pattern of their amylase on a dextran column, and results of immunological analysis. Amylase activity in macroamylasemia is reported to show an anomalous response to increase in reaction-temperature. In this report, measurements of the temperature-activity relationships of serum amylase confirmed that the ratio of serum amylase activity at 50 degrees C to that at 25 degrees C (AMY-50 degrees C/AMY-25 degrees C ratio) in patients with macroamylasemia was higher than that in normal subjects or patients with pancreatitis. Moreover, when macromolecular amylase in the sera of patients with macroamylasemia was separated from amylase of normal molecular weight by dextran gel chromatography, it showed a significantly higher AMY-50 degrees C/AMY-25 degrees C ratio than the latter. Measurement of this AMY-50 degrees C/AMY-25 degrees C ratio seems to be a convenient and useful method for differential diagnosis of hyperamylasemia.

Amylases↗

PubMed1983

The relationship between endotoxin and the phagocytic activity of the reticuloendothelial system.

The frequency of endogenous endotoxemia caused by gram-negative bacteria in the intestine of patients with liver cirrhosis, is attracting much attention in the clinical study of endotoxin. To clarify the reason for such high frequency, the indices of the phagocytic activity of reticuloendothelial system (RES), alpha 2-macroglobulin (alpha 2-M) and endotoxin were studied in patients with chronic liver disease, and in normal controls. In the case of liver cirrhosis, the phagocytic activity of RES (K value) was markedly diminished, and a negative correlation between the K value and alpha 2-M was recognized in endotoxemia. These results suggest that endotoxemia in liver cirrhosis is based on spillover of endotoxins from portal flow.

Adult↗

PubMedDate not supplied

Crow-Fukase syndrome associated with extramedullary plasmacytoma.

A patient with extramedullary solitary tumor had progressive sensory motor neuropathy, generalized pigmentation of skin, pretibial edema and gynecomastia. Serological examination of this patient showed monoclonal IgA-lambda gammopathy. Histologically, the tumor was defined as an IgA (lambda type) positive extramedullary plasmacytoma by using peroxidase anti-peroxidase staining. The tumor was accompanied by angiofollicular lymphoid hyperplasia. Pathologically, it was recognized as an extramedullary plasmacytoma associated with Castleman's disease like changes, and was successfully treated by surgical resection, followed by irradiation.

Aged↗