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Biomedical subjects

H Kumon

Publications and source records attributed to H Kumon.

141 records · Page 8Linked to original sources

[Electron microscopic examinations on foam cells in pigmented villonodular synovitis (PVS) (author's transl)].

The pathologic and histologic features of 17 cases of pigmented villonodular synovitis and bursitis are described. Similar lesions were induced in rabbit knee joints by injection of hypercholesterolaemic serum. A therory is presented that the inflammatory reaction is induced by release of cholesterol esters and crystals from foam cells in a manner similar to crystal-induced synovitis. It is theorized that a disturbance of cholesterol metabolism is responsible for the development of foam cells.

Adult↗

Antioxidative and antimutagenic effects of theaflavins from black tea.

Theaflavins, polyphenolic ingredients of black tea, were observed to inhibit in vitro lipid peroxidation in the erythrocyte membrane ghost and microsomal systems. Theaflavins also showed inhibition of DNA single-strand cleavage and mutagenicity, both induced by hydrogen peroxide. These results suggest that theaflavins scavenge radicals to produce antioxidative and antimutagenic effects. It was also found that the gallic acid moiety of theaflavins is essential for their potent antioxidative activities.

Animals↗

Evaluation of crossing vessels in patients with ureteropelvic junction obstruction by means of helical CT.

Helical computed tomography (CT) was used to demonstrate the distribution of crossing vessels in patients with ureteropelvic junction (UPJ) obstruction for planning surgical management. Twenty patients with symptomatic UPJ obstruction were evaluated with dual-phase contrast material-enhanced helical CT. In addition to axial images, coronal, sagittal, and curved paracoronal images along the crossing vessels or the UPJ were obtained by means of multiplanar reconstruction. Crossing vessels were evaluated according to type, position, and association with UPJ obstruction. Fifteen vessels in 12 of the 20 patients were found to cross the UPJ at helical CT. Nine vessels were arteries and six were veins; seven vessels crossed anteriorly and eight crossed posteriorly. In 11 patients, crossing vessels were thought to be associated with UPJ obstruction at helical CT; retroperitoneoscopic repair was performed, and the diagnosis was found to have been accurate in all except one. In the eight patients in whom no significant vessels were seen and the one patient in whom the crossing vessel was not associated with UPJ obstruction at helical CT, endopyelotomy was performed and UPJ obstruction was relieved, with no complications. Helical CT is useful for evaluation of vessels crossing the UPJ and for planning surgical management.

Adolescent↗

Post-operative infection by pathogenic micro-organisms in the oral cavity of patients with prostatic carcinoma.

The aim of this study was to analyse the change in the oral cavity microflora of 14 patients who had undergone a radical prostatectomy for prostatic carcinoma. The detection of micro-organisms in the oral cavity was compared before and after the surgical procedure. Post-operative infection, defined as those patients who had increased Candida species counts and/or pathogenic bacteria only at the post-operative examination, was observed in 10 patients. Six patients showed increased Candida species counts at the post-operative examination compared with the pre-operative examination. In five patients, pathogenic bacterial species were detected at the post-operative examination but not at the pre-operative examination. One patient had detectable pathogenic bacterial species only at the post-operative examination along with increased Candida species counts. Our findings suggest that pre-operative oral hygiene to remove bacterial and Candida species from patients who are scheduled for surgical procedures is important for satisfactory clinical outcomes.

Aged↗

An improved and simplified method for combined light and scanning electron microscopy in human urinary cytology.

Human bladder-washing and voided urine specimens from normal cases and inflammatory and malignant lesions were examined by the combined use of light microscopy (LM) and scanning electron microscopy (SEM). A newly-designed mesh, which consisted of a piece of gelatin-covered, osmium-impregnated and poly-L-lysine-coated glass slide, 0.85 mm in thickness and containing 42 compartments of 25 sq mm in size, was used in this study. This mesh permitted a direct correlation of LM and SEM images, thus shortening the time of observation of specimens under SEM. With SEM, the diagnosis of malignant exfoliated urothelial cells depended on the presence or absence of pleomorphic microvilli. The technique has enhanced the accuracy of diagnosis over conventional methods, especially for noninvasive, low-grade, papillary tumors of the urinary bladder.

Humans↗