[Pathophysiology and treatment of refractory asthma. 5. An animal model].
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Biomedical subjects
Publications and source records attributed to H Kume.
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Flomoxef (FMOX, 6315-S) was administered to 22 patients with respiratory tract infections. The patients consisted of 13 patients with pneumonia, 7 with bronchitis, 1 with bronchiectasis and 1 with pyothorax. The drug was administered by intravenous injection or intravenous drip infusion twice a day with doses of 1 to 2 g and total doses ranged from 17 to 64 g. The following results were obtained. 1. Clinical responses to the therapy were excellent in 1 case, good in 10 cases, fair in 4 cases, poor in 4 cases and not determined in 3 cases. Efficacy ratio was 57.9%. 2. As for adverse reactions, exanthema in 1 patient and stomatitis and numbness of tongue in another patient were observed, but these symptoms improved with cessation of the therapy. Abnormal laboratory test values were observed in 5 cases. From these results it appears that FMOX is a valuable antimicrobial agent against patients with respiratory tract infections.
A statistical survey of visceral aspergillosis in Japanese pathological autopsies (1972-1981) was carried out. It was found that the infection has increased remarkably in recent years, and the results obtained were briefly described. Pathogenicity of several strains of Aspergillus fumigatus in rabbits was studied on three occasions in the past 31 years. The pathogenicity appeared to be unchanged even after long subcultures for 13 years, while lowered pathogenicity was noted with long-term subcultures over 30 years. However, the lowered pathogenicity of the fungus seemed to be recovered by animal passage.
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Among laboratory mistakes, "specimen mix-up" is the most frequent and the most serious. According to the Clinical Chemistry Laboratory Error Report of Toranomon Hospital, specimen mix-up was often detected when there were many large discrepancies between the results of a test and the results of a previous test. We present here a checking method to detect specimen mix-up. The method, which we call the "multivariate delta check" method, is an extension of the "delta check" method first presented by Nosanchuk and Gottmann (Am. J. Clin. Pathol. 62:707, 1974). Clinical evaluation has demonstrated the effectiveness of the method.
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