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Biomedical subjects

H Krauss

Publications and source records attributed to H Krauss.

At least 91 records · Page 5Linked to original sources
PubMed1986

Safety of ofloxacin--adverse drug reactions reported during phase-II studies in Europe and in Japan.

During phase-II studies monitored by Hoechst AG (Germany) and Daiichi (Japan) and phase-III/IV studies of Hoechst AG 577 adverse drug reactions were recorded among 13,717 patients treated with ofloxacin. Treatment was stopped in about 40% of the patients with adverse drug reactions. Most of the adverse reactions concerned the gastrointestinal tract. 124 adverse reactions concerned the central nervous system, mostly headache and sleep disturbances (n = 84). For the rare occurrences of other symptoms of the central nervous system, such as hallucinations (n = 1), nightmares (n = 1), confusion (n = 1), and depression (n = 2) the data are inadequate to appraise the relative importance of possible contributing factors.

Adolescent↗
PubMed1985

[Cerebrospinal fluid diagnosis of meningeal cryptococcosis].

Cryptococcosis must be taken into account as a cause of basal meningitis. Along with a case report, clinical signs and guiding cerebrospinal fluid findings are evaluated. Special attention is paid to CSF-cytology, which provides important information in terms of identification and clinical course of the disease. For the first time C. neoformans, yielded from CSF-samples, was investigated by means of scanning electron microscopy, and compared with yeast cultured in laboratory.

Adult↗
PubMed1984

[Serodiagnosis of human Q-fever--demonstration of non-complement binding IgM antibodies in the enzyme-linked immunosorbent assay (ELISA)].

The application of an indirect ELISA for detection of IgM and IgG antibodies against Coxiella burnetii in five Q fever patients--among them one with endocarditis and one with hepatitis--is described. In the acute phase of infection, within a few days after onset of clinical symptoms, a significant rise of IgM antibodies could be detected. It was followed by a rise of IgG in the second and third week. In chronic Q fever endocarditis, IgM antibodies persisted over a period of nine months. High IgM and low IgG values indicated acute infection, while in convalescent sera the IgM/IgG relationship was vice versa. In a comparative investigation with complement fixation (CF) test it could be shown that CF antibodies were associated exclusively with immunoglobulin G. IgM separated from IgG by gel chromatography did not fix complement. So, the CF test does not appear to be suitable for detection of antibodies against Coxiella in the early stages of the disease. Because of the persistence of IgG antibodies over a longer period of time, sole detection of a titer against the agent is insufficient for diagnosis of current disease, if not a rise or fall in titer can be detected in a second serum sample. Using the sensitive ELISA technique, a diagnosis is usually possible with one serum sample--in connection with history and clinical investigation--by differentiation of IgM and IgG antibodies.

Antibodies, Anti-Idiotypic↗
PubMed1984

Evaluation of the slide agglutination test for detection of leptospiral antibodies in serum samples of slaughter pigs.

Serum samples of 259 randomly selected slaughter pigs were studied comparatively in the microscopic agglutination test (MAT) and the slide agglutination test (SAT) for the presence of leptospiral antibodies. 12 of 13 serum samples with MAT titres of 1:400+ + and higher were positive in the SAT. 27 of 46 sera with MAT titres in the borderline range (1:100+ + to 1:400+) showed a positive reaction in the SAT. 31 of 200 serum samples with MAT titres of 1:100+ and less reacted also positively in the SAT. Statistical evaluation of the results showed that the SAT is accurate if results are positive but less so if the results are negative (sensitivity 92.3%, specificity 76.4%).

Abattoirs↗