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Biomedical subjects

H Krause

Publications and source records attributed to H Krause.

At least 127 records · Page 7Linked to original sources
PubMed1980

[Stereovectorcardiography. Analysis of congenital excitation-conduction anomalies using a new type of microelectronic equipment (author's transl)].

The results of the first clinical trial of a stereo-VCG used for the quantitative and qualitative analysis of congenital anomalies of excitation-conduction are elaborated and discussed. Normal values for paediatric cardiological patients were calculated for the following parameters with the help of measurements from 78 patients: Pmax, Rmax, Tmax-stereovectors, their elevation and azimut, the stereo-angle between Rmax/Tmax, Pmax/Tmax and Pmax/Rmax as well as the periods from the beginning of the ventricular excitation until Rmax and Tmax. The patients were divided into 4 age groups. The group of normal individuals was compared with 22 patients having anomalies of conduction. The results show that this new technique allows more differentiated analyses of the vector loops registered according to Frank's orthogonal corrected registering system than the conventional measurements in cases of congenital anomalies.

Arrhythmias, Cardiac↗
PubMed1979

[Prolonged survival time of xenogeneic kidney transplants following intravenous application of concanavalin A].

Concanavalin A is used as a mitogen for the stimulation of lymphocytes in vitro. It increases the proliferation of different populations of lymphocytes and activates the function of regulator lymphocytes. This effect appears to be modified in vivo in such a way that daily IV application prolongs survival times of allogeneic and xenogeneic kidney grafts significantly. The reason seems to be an influence on behavior, which is reflected in a pronounced peripheral lymphopenia. To support and investigate this mechanism, further combinations of antilymphocyte globulin, fox red blood cells, and Concanavalin A pretreatment were used in pilot studies.

Animals↗
PubMed1978

[30 years of WHO].

Explore the source record for details and available documents.

History, 20th Century↗
PubMed1978

[Hyperplasia of duodenal lymph follicles accompanied by a defect of immune globulins (author's transl)].

A case report is given of a 60 year old man who complained about burning pain in the right upper abdomen and obstipation. Hyperplasia of the lymph follicles was diagnosed by duodenoscopy. An isolated defect of IgM-globulins was found. Lamblias were demonstrated in the duodenal juice as well. The hyperplasia of the lymph follicles is thought to be a manifestation of the IgM defect.

Agammaglobulinemia↗
PubMed1978

[Syntopy of Bowen's disease and Lewisite scar].

Description of a case of Bown's disease in an area of the right lower leg after lewisite contamination 30 years ago. The possible influence of lost derivatives on carcinogenesis is discussed.

Aged↗
PubMed1976

[Diagnostic significance of cerebrospinal fluid IgG determination by radial immunodiffusion].

The concentration of immunoglobulin G in 455 cerebrospinal fluids has been determined. The results obtained are discussed together with the corresponding total protein and gamma-globulin values. Classification by seven constellations and their assignment to four groups of diseases (acute and inflammatory diseases, chronically inflammatory diseases, E. d., and tumors) allows valuable information to be obtained about the diagnostic significance of IgG determination in the cerebrospinal fluid. This is true especially of E. d. and also applies to an assessment of the activity of inflammatory processes. It is evident from the results of these studies that an evaluation of the IgG value is not possible without considering the total content of protein. The value found for the quotient (see article).

Central Nervous System Diseases↗
PubMed1975

Kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium.

In order to study the kinetics of inactivation and recovery of the slow inward current in the mammalian ventricular myocardium voltage clamp experiments using the double sucrose gap technique were performed on isolated trabeculae and papillary muscles of cats. The separation of the slow inward current from the fast Na current was achieved by use of the conditioning clamp procedure. 1. The decay of the Ca current reflects the inactivation which develops due to depolarization. The rate of inactivation depends upon the membrane potential. Excess Ca (8.8 mM) accelerates the inactivation speed indicating that Ca ions not only act as charge carrier of the slow inward current but might influence in addition the kinetics of the slow membrane channel. In the presence of a lowered temperature a deceleration of inactivation (Q10 2.3) occurs. 2 If the membrane is repolarized a recovery process takes place restoring the availability of the slow membrane channel. As the inactivation the recovery rate depends upon the membrane potential. Excess Ca causes an acceleration whereas a decrease in temperature diminishes the recovery speed (Q10 2.3). Consequently, the Ca supply to the myocardial cell can be modified not only by changes of the transmembrane Ca concentration gradient or by an alteration of the Ca conductance of the slow channel but also by changes in the degree of recovery after a preceding Ca current. 3. Compared with the inactivation the recovery proceeds very slowly. Assuming that this slow recovery represents an inherent kinetic feature of the slow channel the kinetics of inactivation and removal of inactivation are not describable by a single inactivation variable (called as f by Reuter, 1973) which is of the Hodgkin-Huxley type. If a second inactivation variable (called as l) would be introduced additionally a formulation of the inactivation-recovery process of the slow membrane channel on the basis of the Hodgkin-Huxley model becomes feasible.

Action Potentials↗
PubMed1975

Calcium movements controlling mammalian myocardial contractility: analog computation of contractile behavior assuming a multicompartmented model.

We present a model to be displayed on a medium scale analog computer, which describes excitation-contraction (E-C) coupling of the mammalian myocardium in terms of calcium movements occurring, on a sarcomere level, in a multicompartment system, Despite the fact that its mathematical formulations are oversimplifications of the mechanism involved, because the number of differential equations had to be limited, the model predicts with fair accuracy a large variety of inotropic phenomena thought to be the result of factors influencing cardiac E-C coupling in one way or another. Therefore, in its basic assumption, the overall concept might be correct, and if so, it should be possible to use the model in order to make predictions which can be tested experimentally and can help in understanding results which are otherwise difficult to interpret.

Action Potentials↗