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Biomedical subjects

H Kono

Publications and source records attributed to H Kono.

At least 145 records · Page 8Linked to original sources
PubMed1983

Cord serum growth hormone in the human fetus. Sex difference and a negative correlation with birth weight.

Cord venous growth hormone (GH) were measured by radioimmunoassay in 88 infants and 11 anencephalic infants. The mean GH levels decreased gradually from midgestation, preterm to term fetus. There was a significant (p less than 0.01) sex difference in the GH level of term fetuses. Anencephalic infants had low GH levels. There was a significant (p less than 0.01) negative correlation between the cord GH level and birth weight in the normal infant. These data suggest that there is a sex difference for fetal GH secretion and that GH is not so important for fetal growth, but the hypothalamus plays an essential role in the regulation of fetal GH secretion.

Anencephaly↗
PubMed1983

Changes of serum gonadotropin levels and sex differences in premature and mature infant during neonatal life.

We measured FSH and LH concentrations by RIA in 130 cord sera and 213 peripheral sera obtained as serially as possible from 67 infants who were 5-75 days old and were born between the 28th and 42nd gestational weeks. Cord serum FSH and LH (+hCG) levels were 3.9-13.6 mIU/ml and 43.3-88.6 mIU/ml, respectively; they decreased with advancing gestational age. Postnatal FSH levels in male infants maintained low levels (3.7-8.7 mIU/ml). However, those in female infants increased with peak levels (51.8-270.3 mIU/ml) between 11 and 30 days after delivery, and then decreased; the surge was more marked and prolonged in preterm infants than in term infants. Postnatal LH levels in both sexes decreased rapidly after birth, which may be due to a decrease of placental hCG, and thereafter displayed patterns similar to FSH levels. We found a significant sex difference of serum gonadotropin levels in newborn infants and differences between term and preterm infants. Our results suggest that the sex difference of pituitary gonadal function exists and that the function matures during the fetal and neonatal life.

Chorionic Gonadotropin↗
PubMed1983

Simultaneous measurement of human prolactin and growth hormone levels in maternal and fetal serum and amniotic fluid.

Growth hormone (GH) and prolactin (PRL) in maternal and fetal serum and amniotic fluid were measured simultaneously by radioimmunoassay at term deliveries of 20 normal mothers. The PRL level of amniotic fluid was significantly higher than that of maternal and fetal serum. The fetal GH level was significantly higher than the maternal and amniotic levels of GH. There was no significant correlation among hormone levels of maternal and fetal sera and amniotic fluid. These data suggest that PRL and GH levels of maternal and fetal sera and amniotic fluid are controlled separately.

Amniotic Fluid↗
PubMed1983

The effect of sulpiride administration on maternal and fetal plasma prolactin levels, and fetal growth in rats.

Pregnant Wistar rats were daily injected with 5 mg sulpiride into the peritoneal cavity starting on day 14 of gestation. Blood samples were obtained from the maternal carotid artery and fetal axillary vessels on day 20 of gestation. Serum prolactin (PRL) levels were determined by radioimmunoassay using a rat PRL RIA kit. The maternal serum and fetal plasma PRL levels were significantly higher in the sulpiride-treated group than in the saline control group. There was a significant positive correlation between fetal body weight and fetal plasma PRL level. These results suggest that sulpiride which reached the fetus stimulates fetal PRL secretion and that PRL may exert a growth-promoting effect on the fetus.

Animals↗
PubMed1983

Human plasma ACTH, beta-lipotropin and beta-endorphin during delivery.

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) and beta-endorphin (beta-EP) immunoreactivities were measured by high sensitive radioimmunoassay in maternal and umbilical cord plasma samples which were obtained simultaneously in 12 cases. Mean ACTH levels in cord and maternal plasma were significantly higher than those of 8 normal adults. Mean beta-EP to beta-LPH molar ratio of 0.19 in maternal plasma was different from that of cord plasma (0.13). There was no significant correlation between beta-EP levels, or between beta-LPH levels, in the paired fetal and maternal samples. These data suggest that beta-LPH and beta-EP elevate during labor and delivery in response to the stress. Beta-LPH and beta-EP in cord plasma are of fetal and/or placental origin.

Adrenocorticotropic Hormone↗
PubMed1983

[A study on testosterone secretion in neonates].

Serum testosterone (T) concentrations in 106 umbilical venous bloods and 104 neonatal venous bloods, which were obtained from preterm (32-36w) and term (36-41w) infants, were measured by RIA. Cord T levels of boys were higher in preterm infants than in term infants, and those of preterm infants were higher in boys than in girls. Neonatal T levels of girls decreased following delivery. But those of boys increased after 10 days of life. T levels were higher in boys than in girls at 11-30 days of life. Differences between preterm and term infants were not significant.

Female↗
PubMed1982

Correlation of birth weights with umbilical cord serum LH-hCG, FSH, beta-hCG, Estradiol, Cortisol and Testosterone levels.

Luteinizing hormone-human chorionic gonadotropin (LH-hCG), follicle-stimulating hormone(FSH), beta-human chorionic gonadotropin (beta-hCG), estradiol, cortisol and testosterone levels were determined in cord venous serum and the correlation of birth weights with those hormone levels was investigated in 32 male and 35 female fetuses. There were significant negative correlations between LH-hCG or FSH levels and birth weights in the male fetus. Also there was a significant positive correlation between LH-hCG levels and birth weights in the female fetus. This data suggests that there is a sex difference during the development of the pituitary-gonadal axis.

Birth Weight↗
PubMed1982

Radioimmunoassay of urinary calcitonin in normal subjects and in patients with medullary carcinoma of the thyroid.

A simple technique for measuring urine calcitonin (CT) was established using a sensitive radioimmunoassay (RIA) system for plasma human calcitonin (hCT). To extract urinary CT, urine samples were fractioned by gel chromatography on a column (0.8 x 20 cm) of Bio Gel P-2. Recovery of synthetic (1-32)hCT was 86.1 +/- 6.2% and the intra- and inter-assay coefficients of variation in RIA were 5.9 and 8.2%, respectively. Dilution curves of the urinary CT after gel-filtration were parallel with the standard curve. In 11 patients with medullary carcinoma of the thyroid (MCT), the CT levels of the urine (in ng/mg Cr) were 3.4 to 20.8 times higher than those of the plasma (in ng/ml), and a significant positive correlation (r = 0.93, P less than 0.001) was obtained between the urinary and plasma levels of CT in these 11 patients. In 32 normal subjects, the CT levels of the urine (in pg/mg Cr) were only 0.41 to 5.1 times of those of the plasma (in pg/ml), and a weak positive correlation (r = 0.408, P less than 0.05) was obtained between these two levels. However, urinary CT level in normal subjects apparently reflected a rise in endogenous plasma hCT in response to calcium infusion (4 mg/kg B.W. for 1 min) and that of exogenous plasma CT when synthetic (1-32)hCT (500 micrograms for 1 min) was injected intravenously. Following gel filtration on a Bio Gel P-30 1.5 x 80 cm column, larger molecular forms of CT than (1-32)hCT were found in the urine not only patients with MCT but also of normal subjects after infusion of calcium or synthetic (1-32)hCT. It is concluded that measurement of urine CT is useful not only for diagnosis of MCT but also for evaluating CT metabolism in normal subjects.

Adult↗
PubMed1982

Clinical background of preeclampsia in Japanese women.

In Japan, the maternal mortality rate from preeclampsia is still high. In this study, we analyzed the clinical background of 70(1.5%) cases of severe preeclampsia in 4,633 deliveries in our clinic. The main family history was hypertension (34.2%). The medical complication of this pregnancy were nephritis (11.4%), hypertension (5.7%) and diabetes mellitus (4.3%). In previous obstetrical complication, preeclampsia was found very high frequency (44.4%). In this pregnancy, the cesarean section was done for 15 (21.4%) cases. There was a significant high frequency of low birth weight infant in preeclampsia (2,400 +/- 925 gr, mean +/- S.D.). The stillbirth was found in 12 (17.1%) cases. The perinatal mortality rate was 169/1,000 deliveries, this was a significantly higher than total rate (15/1,000 deliveries). These data suggest that it is important to control medical complications before to be pregnant to prevent preeclampsia.

Diabetes Mellitus↗
PubMed1982

[Plasma ACTH, beta-lipotropin and beta-endorphin in the human fetus and their mother during delivery (author's transl)].

Adrenocorticotropic hormone (ACTH), beta-lipotropin (beta-LPH) immunoreactivity (IR) and beta-endorphin (beta-EP) immunoreactivity (IR) were measured by high-sensitive radioimmunoassay in maternal and umbilical cord plasma samples which were obtained simultaneously in 12 cases. Mean IR-beta-LPH in maternal (690.1 +/- 138.6 pg/ml, +/- S.E.) and cord venous plasma (1114.8 +/- 94.2 pg/ml) were significantly higher than that of normal adults (93.0 +/- 8.2 pg/ml). Mean IR-beta -EP in maternal (125.8 +/- 24.0 pg/ml) and cord venous plasma (130.6 +/- 20.6 pg/ml) were significantly higher than that of normal adults (6.0 +/- 0.9 pg/ml). There were significant positive correlations between IR-beta-LPH and IR-beta-EP in maternal and cord venous plasma. Mean beta-EP to beta-LPH molar ratio of 0.19 +/- 0.03 in maternal plasma was significantly (p less than 0.05) higher than that of cord venous plasma (0.13 +/- 0.01). There was no significant correlation between the levels of these three hormones in maternal plasma and the levels in cord venous plasma. These data suggest that ACTH, IR-beta-LPH and IR-beta-EP were elevate during labor, delivery responding the stress. Beta-LPH and beta-EP in cord venous plasma were fetal and/or placental origin.

Adrenocorticotropic Hormone↗
PubMed1982

[Secretion and Sex differences in cord serum growth hormone levels of the human fetus (author's transl)].

Cord venous growth hormone (GH) and somatostatin levels were measured by radioimmunoassay in 86 infants and 11 anencephalic infants. 1) Cord GH levels were 69.2 +/- 20.2 ng/ml (N = 6, gestational weeks (GW) : 21-30W, mean +/- S.D.), 31.5 +/- 24.3 ng/ml (N = 11, GW : 31-36W), and 17.6 +/- 8.9 ng/ml (N = 71, GW: 37-41). In anencephalic infants, cord GH levels were significantly lower (2.3 +/- 1.4 ng/ml) than those in preterm and fullterm infants. 2) In fullterm infants, cord GH levels of small infants (19.2 +/- 9.2 ng/ml, N = 33, birth weight less than 3,250g) were significantly higher than that of large infants (15.1 +/- 8.1 ng/ml, N = 38, birth weight greater than of equal too 3,250g). On the other hands, cord somatostatin levels were relatively lower in small infants than in large infants. 3) There was a significant difference between male cord GH levels (20.6 +/- 8.9 ng/ml, N = 35) and female cord GH levels (14.6 +/- 8.0 ng/ml, N = 36). These results suggest that fetal GH secretion is suppressed by GH inhibiting factor (somatotropin release inhibiting factor) from mid gestation toward term and there is a sex difference of fetal GH secretion in fullterm fetus.

Anencephaly↗