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Biomedical subjects

H Konno

Publications and source records attributed to H Konno.

223 records · Page 13Linked to original sources
PubMedDate not supplied

Relationship of p53 and Helicobacter pylori to clinicopathological features of human remnant stomach cancer after gastric surgery for primary gastric cancer.

The purpose of this study was to evaluate the biological features of gastric cancer of the remnant stomach (RSC). Twenty-one patients underwent resection of the remnant stomach for RSC and were divided into two groups: the RSCB group consisted of 11 patients who underwent distal gastrectomy for benign disease and the RSCM group consisted of 10 patients who underwent gastrectomy for primary gastric cancer. The interval between primary surgery and the appearance of gastric cancer in the remnant stomach was significantly shorter in the RSCM group than in the RSCB group. Invasion of adjacent organs was more frequent in the RSCM group than in the RSCB group and the Ki-67 labeling index of the tumors was significantly higher in the former group. Furthermore, p53 overexpression by tumors was almost twice as common in the RSCM group as in the RSCB group. Although there was no significant difference of the H. pylori positivity between the two groups, the rate for both groups was higher than reported in previous studies. Mutation of p53 may play an important role in the high proliferative activity of tumors in the RSCM group and H. pylori infection may be closely related to carcinogenesis in patients with RSC.

Adenocarcinoma↗
PubMedDate not supplied

Outcome of extensive surgery for TNM stage IV carcinoma of the gallbladder.

BACKGROUND/AIMS: Whether extensive surgery improves the prognosis of patients with advanced gallbladder carcinoma remains unclear. Twenty-three patients with stage IV carcinoma underwent resection of tumors at our department over a period of 19 years. The outcome of extensive surgery was analyzed in this group. METHODOLOGY: Resection of segments 4a plus 5, extended right lobectomy or right trisegmentectomy, and hepatopancreatoduodenectomy (HPD) were performed in 5 patients, 7 patients, and 11 patients, respectively. Extrahepatic bile duct resection, regional lymph node dissection and paraaortic node dissection were performed in all patients. The survival rate after operation was compared to that of 39 patients with unresectable tumors. RESULTS: The morbidity rate was high (60.8%), but there were no post-operative deaths. The 1-, 3- and 5-year survival rates were 51%, 17%, and 11%, respectively. The longest survival time of stage IV carcinoma patients was 18 years. The 5-year survival rate of 6 patients undergoing curative resection was significantly better than that of 17 patients undergoing noncurative surgery (p < 0.05). The survival of 11 patients undergoing HPD and 7 patients with para-aortic nodal metastasis were both significantly improved compared to that of patients with unresectable tumors (p < 0.05). The quality of life and the out-of-hospital period were also better. CONCLUSIONS: Extensive surgery for stage IV gallbladder carcinoma has a good palliative effect.

Adult↗
PubMedDate not supplied

Hepatectomy for hepatocellular carcinoma in a renal transplant patient--report of a case and literature review.

A 45-year-old woman underwent hepatectomy for hepatocellular carcinoma developing after 2 renal transplants. She had a solitary hepatocellular carcinoma and central bisegmentectomy of the liver was performed. Administration of immunosuppressants was continued to maintain renal function in the perioperative period. Although our patient suffered from severe pneumonia postoperatively, she recovered without a decline in renal function. She has been alive for 1 year and 3 months after hepatectomy with hepatocellular carcinoma recurrence in the remnant liver. Any patient undergoing hepatectomy for hepatocellular carcinoma after renal transplantation should be managed as an immunocompromised host. Previously reported cases of hepatectomy for hepatocellular carcinoma in renal transplant recipients were reviewed.

Carcinoma, Hepatocellular↗
PubMedDate not supplied

Piroxicam-induced regression of intestinal adenomatous polyps in APC(delta474) mice.

Mutation of adenomatous polyposis coli (APC) gene results in incidence or development of polyps and colorectal cancer. It has been reported that nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cell growth, cause cell cycle arrest, and induce apoptosis. The aims of this study are to investigate chemopreventive effects of piroxicam and elucidate its mechanism. All APC(delta474) mice have intestinal polyps. Thirty-five APC(delta474) mice were divided into three groups: 0.005% solution of piroxicam in tap water was given for P group (n = 15) and 0.001% solution for P' group (n = 5), and water without piroxicam for C group (n = 15) from 4 weeks of age to 12 weeks, respectively. All mice were sacrificed at the 12th week after birth. Hematoxylin-eosin staining for number and size of polyps, immunohistochemical staining for cyclooxygenase (COX)-1 and -2, proliferating cell nuclear antigen (PCNA), vascular endothelial growth factor (VEGF), TUNEL method, and Western blot analysis of COX-2 and VEGF were performed. Polyps were divided into two types of large polyps of >or=300 microm in diameter and small polyps of <300 microm. The number of large polyps in P group decreased significantly compared with C group (p <.0001), but without significant difference in small polyps. There were no significant differences in PCNA index in both of large and small polyps among the three groups. Apoptotic index of polyps in P group increased more than those in C group (p <.05). There was immunohistochemically no significant difference in COX-1 positivity of normal intestinal epithelia and adenomas among three groups. Both numbers of VEGF-positive cells and COX-2 positive cells in the stroma of the small intestine were significantly downregulated in P group (p <.05). COX-2 expression was inhibited in dose-dependent manner without significant difference. There were no significant differences in VEGF expression between P' and C groups. In conclusion, piroxicam suppressed the development of large polyps in APC(delta474) mice by inducing apoptosis and inhibiting VEGF expression in interstitial cells of polyps.

Adenomatous Polyposis Coli↗
PubMedDate not supplied

Sarcoidosis presenting as progressive myelopathy.

A case of intramedullary spinal cord sarcoidosis with slowly progressing symptoms and signs attributable solely to the spinal cord is reported. Biopsy disclosed granulomatous foci but was not diagnostic of sarcoidosis. However, autopsy showed numerous minute granulomas compatible with those of sarcoidosis disseminated in the lower cervical and upper thoracic cord in addition to a few in the hilar lymph nodes and papillary muscle of the heart. Clinical and pathological features of eight cases of sarcoidosis without symptoms other than those of the spinal cord are reviewed from the literature and clues to the diagnosis are discussed.

Female↗
PubMedDate not supplied

Resection of metastatic liver tumors with special reference to hepatic venous system.

BACKGROUND/AIMS: When the right and middle hepatic veins (RHV and MHV) and all the short hepatic veins are removed during resection of segments (S) 7 + 8 including the caudate lobe, the remainder of (S) 5 + 6 shows congestion. METHODOLOGY: The subjects were 8 patients undergoing hepatectomy (7 with hepatic metastases of colorectal carcinoma and 1 with pancreatic carcinoid) for tumors located in the region circumscribed by the RHV, MHV, and inferior vena cava. Direct hepatic vein anastomosis was done in 5 patients, graft replacement of the MHV was done in 1 patient, and graft replacement of the RHV was done in 2 patients. RESULTS: Hepatic vein reconstruction took approximately 20 min to complete. All 8 patients had an uneventful postoperative course and the anastomosis was patent at one month after operation. Three patients died of recurrent carcinoma at 6, 30, and 48 months after operation, respectively. Five have remained alive and disease-free for 18, 30, 46, 67, and 79 months, respectively. CONCLUSION: Hepatic vein reconstruction is a beneficial option in hepatectomy for patients with carcinoma invading the major hepatic veins and short hepatic veins, since it can allow radical tumor resection and preserves the remnant liver function. In particular, direct hepatic vein anastomosis is recommended because it is a simple technique with good results.

Aged↗