Maternal mortality in University Hospital Kuala Lumpur, Malaysia.
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Abortion, Septic↗
Biomedical subjects
H Kong
Publications and source records attributed to H Kong.
The radiation-sensitive costimulatory factors involved in B-cell-dependent T-cell activation by minor lymphocyte stimulating antigen.
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Abatacept↗
Microsatellite allelotyping of chinese nasopharyngeal carcinomas.
BACKGROUND: Chinese nasopharyngeal carcinoma (NPC) specimens were analyzed by microsatellite allelotyping to evaluate their usefulness as biomarkers for cancer detection. MATERIALS AND METHODS: A panel of eight microsatellite markers localized to chromosomes 3p, 6p, 9p, I1q and 14q were used to study 47 specimens. RESULTS: A moderately low loss of heterozygosity (LOH) frequency (8% to 35%) was observed; 23 (49%) specimens showed LOH with at least one marker while microsatellite instability (MSI) was detected in 10 specimens (21%). CONCLUSION: Poor survival was significantly associated with LOH detected by a chromosome 3 marker. Interestingly, tumors with multiple genetic alterations were significanty associated with earlier staging
Adult↗
Does BcgI, a unique restriction endonuclease, require two recognition sites for cleavage?
BcgI is a multi-subunit restriction-modification (R-M) complex. BcgI prefers pBR322 DNA over pUC19 in a DNA cleavage reaction. Linearized pBR322 contains two BcgI recognition sites and pUC19 has only one site. To test whether two target sites are required for BcgI cleavage, one of the two sites in pBR322 was deleted, and as a result pBR322-1 became a poor substrate for BcgI. Conversely, adding a BcgI site to pUC19 makes it a much better substrate for BcgI cleavage. In addition, the BcgI (R-M) complex forms a heterohexamer in solution that is capable of interacting with two recognition sites. Our results suggest that BcgI requires two recognition sites for cleavage.
Binding Sites↗