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Biomedical subjects

H Kojima

Publications and source records attributed to H Kojima.

At least 667 records · Page 37Linked to original sources
PubMed1983

Distribution of abnormal Q waves on body surface in relation to left ventricular wall motion abnormalities in myocardial infarction.

This study was undertaken to determine the possible one-to-one relationship between each site of asynergy of the left ventricle and the body surface area to which ensuing abnormal electrical phenomena are reflected. In 140 post-myocardial infarction (MI) patients, distribution of abnormal Q waves on the body surface was correlated with the abnormal segments of LV wall motion identified by left ventriculography (LVG). Unipolar lead electrocardiograms (ECGs) were recorded from 87 lead points over the precordium and the back with Wilson's central terminal as the reference point. Data acquisition and mapping was accomplished through a mapping system HPM 5100 microcomputer. In all cases, coronary arteriography (CAG) and LVG were performed at least 2 months after the acute episode of MI. The LVG findings were evaluated separately in seven wall segments in accordance with the American Heart Association (AHA) reporting system. Sensitivity, specificity, diagnostic accuracy, positive predictive value, and negative predictive value of the abnormal Q wave in each lead point were obtained in cases with abnormal wall motion in segments 2, 3, and 6, respectively, and in infero-posterior segments 4 or 5. Statistical analysis was performed by comparing two groups of patients with or without asynergy of each wall segment concerned. Results of the study revealed some abnormal Q areas of high diagnostic accuracy that correlated highly with the site of abnormal contractility.

Journal Article↗
PubMed1983

[Oyster-associated hepatitis A].

We have experienced ten cases of hepatitis, type A, from March to April in 1983. All patients have taken raw oyster before hepatitis developed. The symptoms such as fever and/or diarrhea developed within 4 weeks after the patients have taken oyster. No cases of hepatitis in children were found out. From these results, it was concluded that the causes of hepatitis, type A, which we have experienced, are associated with raw oyster. HAV was not detected in shellfish by the method of radioimmunoassay.

Adult↗
PubMed1982

The short- and long-term effects of haloperidol on rat central dopamine turnover.

We carried out a quantitative fluorescent histochemical analysis in rats in order to clarify the effects of chronic treatment with haloperidol on the central dopamine turnover. Long-term treatment with haloperidol showed no significant reduction of dopamine fluorescence intensities in the n. caudatus putamen, the n. accumbens, and the tuberculum olfactorium. This suggests that tolerance is established after long-term treatment with haloperidol in both mesolimbic and nigrostriatal dopamine systems, whereas tolerance is not observed in the tuberoinfundibular dopamine system.

Animals↗
PubMed1982

Biochemical changes after surgical stress in rabbits.

Biochemical changes in blood, i.e. glucose, ketone bodies, lactate, protein, blood urea nitrogen (BUN), and free alanine before and after surgical stress were measured in normal and diabetic rabbits. Both the normal and diabetic rabbits were divided into two groups; the acute phase (0 to 180 minutes after surgery) and the subacute phase (1 to 3 postoperative days). Surgical stress was induced by performing laparotomy under anesthesia. Glucose, ketones, lactate, BUN, and alanine were higher in diabetic than normal animals. Protein level was lower in the diabetics. In the acute phase, normal and diabetic animals showed a similar reaction. In the subacute phase, ketone bodies and BUN increased predominantly in normal animals with no change of glucose levels. In two of the diabetics, an increase in glucose, lactate and alanine was seen. These phenomena support Bessman's postulation of stress which has two of phases, the catecholamine phase and the pituitary-adrenal phase. It is considered that this reaction to surgical stress in the acute phase is due to glycogenolysis i.e., glucose from glycogen and lipolysis i.e., ketones from fat induced by catecholamine, and that increased ketone bodies and glucose levels in the subacute phase are due to ketogenesis i.e., ketones from protein and gluconeogenesis i.e., glucose from protein. In both phases ketonemia is predominant in normal rabbits after surgical stress, suggesting that insulin does not reduce directly lipolysis in the acute phase and ketogenesis in the subacute phase, under conditions of stress.

Alanine↗
PubMed1982

Distribution and accumulation of [2,3-14C]acrylonitrile in rat after single injection.

The distribution and accumulation of acrylonitrile after the single i.p. injection of [2,3-14C]acrylonitrile were examined by whole-body autoradiography and by the determination of 14C radioactivities in several tissues and subcellular fractions after a whole-body perfusion. 14C Radioactivity was seen strongly in blood, particularly in red blood cells, and in several tissues including lung, liver, and kidney. Longer retention of radioactivity in brain and muscle was observed. At the subcellular level a relatively high specific radioactivity was seen in cytosol fractions of the brain, liver, and kidney.

Acrylonitrile↗
PubMed1982

Occurrence of 2-O-acyl galactosyl ceramide in whale brain.

Four glycolipids (Fr. I, II, III, and IV) were isolated from whale brain and three (Fr. I, II, and III) of them were demonstrated to be galactosyl ceramide combined with fatty acid by ester linkage. Fr. IV was shown to be a monoalkyl monoacyl galactosyl glycerol. For determining the substituted position of the acyl group on the galactose moiety, free hydroxyl groups of ester cerebrosides were protected with dihydropyran, deacylated by mild alkali treatment, and then subjected to permethylation. Finally, the methylated galactitol acetates obtained by hydrolysis and reduction were detected by gas chromatography and identified by gas chromatography-mass spectrometry. By this procedure, Fr. I was shown to be an acyl ester of kerasine, with the ester group at the 6-position of galactose. Fr. II and III were demonstrated to be acyl esters of phrenosine, in which the acyl groups were attached to the 6- and 2-position of the galactose, respectively. While the ester-linked acyl group of Fr. I, II, and III was composed of only normal fatty acids, predominantly palmitic acid, and the amide-linked fatty acids showed a heterogeneous composition of normal and hydroxy fatty acids, C16 to C24.

Animals↗