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Biomedical subjects

H Kluge

Publications and source records attributed to H Kluge.

At least 19 recordsLinked to original sources

Absorbed dose to water determination with ionization chamber dosimetry and calorimetry in restricted neutron, photon, proton and heavy-ion radiation fields.

Absolute dose measurements with a transportable water calorimeter and ionization chambers were performed at a water depth of 20 mm in four different types of radiation fields, for a collimated (60)Co photon beam, for a collimated neutron beam with a fluence-averaged mean energy of 5.25 MeV, for collimated proton beams with mean energies of 36 MeV and 182 MeV at the measuring position, and for a (12)C ion beam in a scanned mode with an energy per atomic mass of 430 MeV u(-1). The ionization chambers actually used were calibrated in units of air kerma in the photon reference field of the PTB and in units of absorbed dose to water for a Farmer-type chamber at GSI. The absorbed dose to water inferred from calorimetry was compared with the dose derived from ionometry by applying the radiation-field-dependent parameters. For neutrons, the quantities of the ICRU Report 45, for protons the quantities of the ICRU Report 59 and for the (12)C ion beam, the recommended values of the International Atomic Energy Agency (IAEA) protocol (TRS 398) were applied. The mean values of the absolute absorbed dose to water obtained with these two independent methods agreed within the standard uncertainty (k = 1) of 1.8% for calorimetry and of 3.0% for ionometry for all types and energies of the radiation beams used in this comparison.

Calorimetry↗

Effect of benzoic acid on growth performance, nutrient digestibility, nitrogen balance, gastrointestinal microflora and parameters of microbial metabolism in piglets.

In order to investigate the effects of benzoic acid on growth performance, nutrient digestibility, nitrogen balance and gastrointestinal microflora of piglets, we conducted a performance experiment and a separate balance study. The performance experiment involved four different dietary treatments: (1) basal diet (negative control); (2) basal diet supplemented with benzoic acid at 5 g/kg; (3) basal diet supplemented with benzoic acid at 10 g/kg; (4) basal diet supplemented with potassium diformate at 12 g/kg. Each dietary treatment was assigned to nine replicate groups, each consisting of two piglets. Live weight, daily weight gain, feed intake and feed conversion ratio were monitored as performance parameters over a 35-day period. Supplementation of the diet with benzoic acid resulted in a dose-dependent increase in feed intake and body weight gain and an improved feed conversion ratio. Piglets fed the diet supplemented with benzoic acid at 10 g/kg outperformed the control piglets in mean feed intake, body weight gain and feed conversion ratio by 9%, 15% and 6% respectively. Growth performance of the piglets fed the diet with benzoic acid at 10 g/kg was similar to that of piglets fed the diet supplemented with potassium diformate. In the balance experiment three groups of six piglets each were fed either a control diet or diets supplemented with benzoic acid at 5 or 10 g/kg respectively. Benzoic acid did not significantly affect nutrient digestibility but increased nitrogen retention. Piglets fed the diets supplemented with benzoic acid at 5 or 10 g/kg retained 5% and 6% more nitrogen, respectively, than control piglets. Supplementation of benzoic acid did not influence the pH value or the concentration of ammonia in the gastrointestinal tract but reduced the number of bacteria in the digesta. In the stomach the number of total aerobic, total anaerobic, lactic acid forming and gram-negative bacteria was reduced; in the duodenum the presence of benzoic acid reduced the number of gram-negative bacteria and in the ileum the number of total aerobic bacteria in a dose-dependent manner. Benzoic acid also considerably reduced the concentration of acetic acid in the duodenum. In conclusion, the data of this study suggest that benzoic acid exerts strong antimicrobial effects in the gastrointestinal tract of piglets and therefore enhances growth performance and nitrogen retention.

Animal Feed↗

Effects of L-carnitine supplementation in pregnant sows on plasma concentrations of insulin-like growth factors, various hormones and metabolites and chorion characteristics.

Previous studies have shown that supplementation of sow diets with L-carnitine increases the body weight of piglets at birth. This study was conducted to elucidate the reasons for this phenomenon. Three experiments with 24 (experiment 1), 40 (experiment 2) and 12 (experiment 3) sows were conducted. In all three experiments, sows were allotted to two groups which had free access to a nutritionally adequate diet. Sows of one group were supplemented with 125 mg L-carnitine/day during pregnancy; sows of the other group (control group) did not receive L-carnitine. In experiment 1, plasma samples were collected at day 95 of pregnancy, in experiment 2 plasma samples were collected at days 80 and 100 of pregnancy. In experiment 3, chorions of the sows were collected at parturition. L-carnitine-treated sows had higher plasma concentrations of total L-carnitine than control sows (p < 0.05). The number of piglets born and weights of litter and individual piglets at birth were not different between both groups in all three experiments. L-carnitine-treated sows had higher plasma concentrations of insulin-like growth factor-I (IGF-I) on day 80 of pregnancy (experiment 2, p < 0.05) and on day 95 (experiment 1, p < 0.10), and a higher plasma concentration of IGF-II on day 80 (experiment 2, p < 0.05) than control sows. Moreover, sows supplemented with L-carnitine had heavier chorions (+22%, p =0.10) with greater amounts of protein (+45%, p < 0.05) and DNA (+38%, p < 0.10) and a higher protein concentration of glucose transporter-1 (+62%, p < 0.05). Plasma concentrations of 17beta-oestradiol, progesterone and thyroid hormones as well as concentrations of urea and total free amino acids were not different between both groups of sows. Plasma concentrations of non-esterified fatty acids, ketone bodies, triacylglycerols and cholesterol were also largely indifferent between both groups of sows. In conclusion, this study shows that L-carnitine has less influence on lipid metabolism and utilization of nitrogen in pregnant sows but increases their plasma concentrations of IGFs. This in turn may enhance development of the placentae and the intrauterine nutrition of the fetuses. This may be the reason for increased birth weights observed in recent studies in sows supplemented with L-carnitine.

Animal Nutritional Physiological Phenomena↗

Private GPs contribute to TB control in Myanmar: evaluation of a PPM initiative in Mandalay Division.

SETTING: Mandalay Division, Myanmar. AIM: To assess the effect of an initiative to involve private general practitioners (GPs) in the National Tuberculosis Programme (NTP) and to identify lessons learnt for public-private mix scale-up. METHODS: Source of referral/diagnosis and place of treatment were included in the routine recording and reporting systems to enable disaggregated analysis of the contribution of GPs to case notification and treatment outcomes. Case notification trends were compared between the intervention and control areas over a 4-year period. RESULTS: Private GPs contributed 44% of new smear-positive cases registered during the study period (July 2002-December 2004). The notification of new sputum smear-positive TB in the study area increased by 85% between the year prior to the GP involvement and 2 years after (from 46 to 85/100,000). Case notification increased by 57% in the control townships and by 42% in all of Mandalay Division. The treatment success rate for new smear-positive cases treated by GPs was 90%. CONCLUSIONS: The involvement of private GPs substantially increased TB case notification, while a high treatment success rate was maintained. Success factors include a well-developed local medical association branch, strong managerial support, training and supervision by the public sector and provision of drugs and consumables free of charge by the NTP.

Family Practice↗

[Evidence based community psychiatric community health care services in Germany: taking inventory].

PURPOSE AND METHODS: One of the outcomes of reforming mental health care in Germany has been the establishment of a range of community mental health services. However, current evidence for the effectiveness of these services is slight. Based on a literature search this article provides a systematic overview of empirical research in this sphere. In detail, social psychiatric services, crisis centres, psychosocial contact points, day care centres, and various models of supported housing and work/employment are assessed. Available results on effectiveness are classified according to their level of scientific evidence. RESULTS: The current state of research is characterised by the situation that effectiveness of the care approach provided by social psychiatric services and some types of supported housing and work/employment has been demonstrated at a medium level of scientific evidence. In contrast, the evidence level of mental health care provided in crisis centres, psychosocial contact points, and day care centres is poor. CONCLUSION: The major reasons for this lack of research are: heterogeneity of care models and staffing levels in the different community mental health services, lack of standardised documentation and reporting system in these services, and lack of research culture to utilise routine outcome data. The consequences of aiming at increasing the level of scientific evidence in this sphere would be to intensify funding of research projects and to implement high quality research designs such as randomised controlled trials.

Clinical Trials as Topic↗

Effects of L-carnitine supplementation on milk production, litter gains and back-fat thickness in sows with a low energy and protein intake during lactation.

The present study investigated the effect of L-carnitine supplementation during pregnancy (125 mg/d) and lactation (250 mg/d) on milk production, litter gains and back-fat thickness in sows fed a low-energy and low-protein diet during lactation. Sows supplemented with L-carnitine produced more milk on days 11 and 18 of lactation (+18 %; P<0.05) and had higher litter gains during suckling (+20 %; P<0.01) than control sows. Loss of body weight during lactation was similar in both groups, but sows supplemented with L-carnitine had a greater reduction of back-fat thickness (+45 %; P<0.05) during lactation than control sows. In conclusion, this study shows that L-carnitine increases milk production and litter gains in sows in a strongly negative energy and N balance, and enhances body fat mobilisation.

Adipose Tissue↗

Effect of dietary L-carnitine supplementation on growth performance of piglets from control sows or sows treated with L-carnitine during pregnancy and lactation.

Previous studies showed that supplementation of sows' diets with L-carnitine increases body weights of their piglets at birth. This study was performed to investigate whether piglets of sows treated with L-carnitine differ in their growth potential from that of piglets of untreated control sows after weaning. It was also investigated whether supplementation of piglets' diets with L-carnitine improves their growth after weaning. In two trials, piglets of the first litters of primiparous sows (trial 1) and the second litters of the same sows (trial 2) were divided into four groups: group 1, piglets of control sows, fed a control diet; group 2, piglets of control sows fed a diet supplemented with 30 mg L-carnitine/kg; group 3, piglets of L-carnitine-treated sows, fed a control diet; group 4, piglets of L-carnitine-treated sows fed a diet supplemented with 30 mg L-carnitine/kg. Mean initial body weights of the piglets of the four groups were identical. They were 8.5 kg in trial 1 and 12.5 kg in trial 2. Diets were fed ad libitum over a period of 35 days. Piglets from sows treated with L-carnitine did not differ in body weight gains, feed intake and gain : feed ratio from those of control sows. In trial 1, piglets supplemented with L-carnitine had higher body weight gains (p < 0.005) and showed a tendency towards a higher gain : feed ratio (p = 0.09) than piglets fed the control diets. In trial 2, no significant difference in these parameters emerged between piglets fed the diet supplemented with L-carnitine and those fed the control diet. In conclusion, this study shows that dietary L-carnitine treatment of sows does not improve the growth potential of their piglets after weaning under the conditions of equal initial body weights. The study also shows that L-carnitine supplementation of their diets improves the growth performance in light piglets of primiparous sows.

Animal Feed↗

Effect of dehulling of rapeseed on feed value and nutrient digestibility of rape products in pigs.

In the presented study the influence of dehulling rapeseed on the composition of rapeseed meal (RM) and rapeseed cake (RC) and on its feed value for piglets and growing-finishing pigs was investigated. Before withdrawal of oil, rapeseed (variety Express) was dehulled applying a procedure developed by SKET GmbH Magdeburg and the Section Food-Technology of the University Essen. The steps of the dehulling procedure were described. For RM the oil was removed by the prepress-solvent procedure till a crude fat content of 2.1% in DM. RC was produced by pressing only resulting approximately 13% crude fat in DM. The RM and RC from not dehulled (ND) and dehulled (D) rapeseed were examined analytically. Crude nutrients, sugar and fibre substances, amino acids, some minerals and trace elements, fatty acids, glucosinolates and sinapine, and phytate were determined. By dehulling the seed the crude fibre content was decreased in RM and RC by approximately 40%. The ADF content declined by 35 and 39%, and the NDF content by 28% and 40% in RM and RC, respectively. The decrease in ADL content amounted to 50% and 65% for RM and RC, respectively. On the other hand, the CP content of RM and RC was increased by 7% and 13%, respectively, by dehulling the seed while the amino acid content of rape protein increased only slightly. The contents of glucosinolates and sinapine were also increased by dehulling, while the contents of phytate and phytate P were decreased. In digestibility and balance experiments with piglets and intact hybrid breeds of growing-finishing pigs, the digestibility of organic matter and of crude nutrients and the contents of digestible energy and metabolizable energy were estimated. Furthermore, the precaecal digestibility of crude nutrients and amino acids was determined with fistulated mini-pigs. By dehulling the seeds the digestibility of organic matter from RM and RC was improved in piglets and adult pigs by approximately 10%, and the ME contents increased by 13-15%. The precaecal digestibility of the sum of amino acids was increased by approximately 3 and 6 units in RM and RC, respectively. The precaecal digestibility of lysine in RM and RC reached that of soybean oil meal from not dehulled beans.

Amino Acids↗

Risk factors for death during tuberculosis treatment in Orel, Russia.

SETTING AND METHODS: In Orel, high tuberculosis (TB) case fatality rates have persisted despite successful implementation of the World Health Organization (WHO) global TB control strategy. We conducted a case control study to identify risk factors for mortality among Orel TB patients reported from October 1999 through June 2001. Cases were patients who died within 8 months of treatment initiation. We analyzed data abstracted from medical records using conditional logistic regression. RESULTS: Over the 21-month period, 63/1069 (5.9%) TB patients overall and 45/521 (8.6%) sputum smear-positive patients died during treatment. Compared to 192 controls, independent risk factors for death for both smear-positive and smear-negative patients included unemployment (adjusted odds ratio [AOR] 4.9, 95% confidence interval [CI] 1.9-12.9), homelessness (AOR 9.5, 95% CI 1.3-70.9), congestive heart failure (AOR 5.4, 95% CI 1.9-15.9), chronic lung disease (AOR 2.4, 95% CI 1.1-5.4), cancer (AOR 7.2, 95% CI 1.2-45.0), bilateral disease on chest X-ray (AOR 6.3, 95% CI 2.3-17.1), and hyperbilirubinemia (AOR 5.2, 95% CI 1.1-25.3). Among deaths, the median time from treatment initiation to death was 35 days. CONCLUSIONS: The diagnosis and treatment of TB in suspects with the observed comorbidities and risk factors should be aggressively pursued. The association of unemployment and homelessness with mortality suggests a contribution of poverty to death during TB treatment.

Adolescent↗

Tryptophan requirement of growing pigs at various body weights.

The purpose of this study was to determine the tryptophan (Trp) requirement of growing pigs at different body weight (BW) ranges. Three performance experiments were conducted with female pigs in the BW ranges of 25-50, 50-80 and 80-115 kg. In addition to the performance experiments, nitrogen balance experiments were carried out in which pigs weighing 56, 66 and 86 kg were used. Trp-deficient basal diets were formulated to which varying amounts of l-Trp were added. The amino acid concentrations of the diets were analysed; concentrations of standardized digestible amino acids were calculated on the basis of tabular values. The calculated concentrations of standardized ileal digestible tryptophan were 0.81, 1.11, 1.41, 1.71, 2.01 g/kg diet in the lower BW range (25-50 kg), 0.71, 0.96, 1.21, 1.46, 1.71 g/kg diet in the middle BW range (50-80 kg), and 0.49, 0.69, 0.89, 1.09, 1.29 g/kg diet in the upper BW range (80-115 kg). Dose-response relationships were evaluated by means of an exponential regression model. In all three age ranges, performance parameters as well as nitrogen retention were strongly influenced by the dietary concentration of standardized ileal digestible tryptophan. According to the exponential model, in the 25-50 kg BW range, 95% of the maximum feed consumption, BW gain and nitrogen retention were achieved at concentrations between 1.96 and 2.00 g of standardized ileal digestible Trp per kilogram diet, corresponding to 3.32-3.39 g/day. In the BW range of 50-80 kg, 95% of the maximum of these parameters occurred at concentrations of standardized ileal digestible tryptophan in excess of the highest concentration of 1.71 g/kg diet, corresponding to 3.71 g/day. In the BW range of 80-115 kg, 95% of the maximum of BW gain and nitrogen retention were recorded at concentrations of 1.22 and 0.84 g standardized ileal digestible Trp per kilogram diet, corresponding to 3.77 and 2.25 g/day, respectively. Related to the energy value of the diets, the optimal concentration of standardized ileal digestible tryptophan are between 140 and 143 mg/MJ metabolizable energy (ME) in the BW range of 25-50 kg, in excess of 127 mg/MJ ME in the BW range of 50-80 kg and between 62 and 90 mg/MJ ME in the BW range of 80-115 kg. In conclusion, it is suggested that the requirement of standardized ileal digestible tryptophan for growing pigs might be higher than currently assumed.

Animals↗

Encouraging outcomes in the first year of a TB control demonstration program: Orel Oblast, Russia.

SETTING: Orel, Russia. OBJECTIVE: To evaluate outcomes of tuberculosis (TB) patients treated in the first year of a TB control demonstration project using a revised strategy of directly observed treatment, short-course (DOTS). Standard methods recommended by World Health Organization (WHO) were adapted to include mycobacterial cultures. DESIGN: Retrospective cohort analysis of TB patients diagnosed between October 1999 and September 2000. RESULTS: Among 749 TB patients, 65% had bacteriologic confirmation of pulmonary TB, 31% were diagnosed clinically, and 4% had extra-pulmonary TB. Most (92%) had no previous TB treatment, but 8% were identified as retreatment cases. Of all patients, 41% had new sputum smear-positive TB. No patients were HIV-infected. Multidrug-resistant (MDR) TB levels were 3% among new and 17% among retreatment patients. Among new smear-positive patients, treatment success was 79% (72% cure, 7% completion); remaining outcomes were 8% failure, 3% default, 8% death, and 1% transfer. Success rates for new culture-positive and clinically diagnosed patients were 81% and 91%, respectively. CONCLUSION: Despite historical differences, successful implementation of the revised TB strategy in Russia is possible. Treatment success rates were high, suggesting WHO targets of 85% cure for smear-positive patients is attainable. Obstacles include drug resistance and elevated death rates among smear-positive patients.

Adolescent↗

[Thrombocytic serotonin concentration in depressed children and adolescents].

OBJECTIVES: This study pursued the question to what extent a correlation exists between the platelet serotonin concentration and depressive and/or suicidal behaviour in children and adolescents. METHODS: Within a 16-month period, the platelet serotonin concentration was determined in all admitted inpatients (n = 145, age: 4 to 19 years) by means of fluorescent spectroscopy according to a standardised protocol. The severity of depressive symptoms was assessed by administration of the DIKJ to a subset of patients. The different diagnostic groups were formed according to the criteria of the ICD-10. RESULTS: A decrease in the platelet serotonin concentration was found with increasing age. While platelet serotonin concentrations were higher in male patients than in females, the girls showed higher depression scores on the DIKJ. A negative correlation existed between the platelet serotonin concentration and the degree of depression measured on the DIKJ in all diagnostic groups. Independent of the clinical diagnosis significantly lower concentrations of platelet serotonin were found in children and adolescents who had attempted suicide immediately before admission to hospital. The same is true for the group of depressive disorders, with a subgroup of patients who had attempted suicide shortly before also showing significantly lower concentrations of platelet serotonin. CONCLUSIONS: The present investigation supports the contention that depression in childhood and adolescence is related to a lack of serotonin in platelets, respectively, analogous to the platelet model, to a lack of serotonin in central structures, and that a relative serotonin deficiency could thus be an indicator of suicidal ideation.

Adolescent↗

Reproductive performance of sows supplemented with dietary L-carnitine over three reproductive cycles.

The effect of L-carnitine supplementation during pregnancy and lactation on the reproductive performance of sows was studied in two separate trials over three reproductive cycles. Both trials were identical in design and conduct but were performed with different animals. The trials comprised of a total of 127 sows (trial 1) and 100 sows (trial 2) which were divided into control and treatment groups. All animals were fed individually and received basic feed mixtures with low native carnitine concentrations. The rations of the sows in the treated group were supplemented with 125 mg L-carnitine per head and day during pregnancy and 250 mg L-carnitine per head and day during lactation. The animals of the control group received identical feed mixtures in identical amounts, but without the L-carnitine supplement. In the first trial, 212 litters were produced and evaluated for number and body weight of the animals, in the second trial, 173 litters were produced. L-carnitine supplementation significantly increased body weight gains of the sows between day 1 and day 85 of weaning. The number of born piglets, stillborn piglets and piglets fit for rearing was not influenced by dietary L-carnitine supplementation. However, L-carnitine supplementation significantly increased the weights of piglets and litters at birth, weight gains of litters during suckling and weights of litters at weaning. These effects of L-carnitine were seen in both trials; they were independent of the age of the sows and remained over three reproductive cycles in which the sows where continuously treated with L-carnitine. Overall, the study shows that dietary supplementation with L-carnitine during pregnancy and lactation improves the reproductive performance of sows over several reproductive cycles, independent of the age of the sows.

Animals↗

Anti-tuberculosis drug resistance in community and prison patients, Orel Oblast, Russian Federation.

SETTING: Orel Oblast, Russian Federation. OBJECTIVES: To determine baseline levels of anti-tuberculosis drug resistance in Orel Oblast. DESIGN: Drug susceptibility testing (DST) records from 1 July 1999 to 30 June 2000 for patients with sputum acid-fast bacilli smear-positive pulmonary tuberculosis were reviewed. Treatment and incarceration status were obtained from the tuberculosis register. Patients with 1 month or less of prior treatment were defined as new cases; those previously treated for more than 1 month were defined as retreatment cases. RESULTS: Of 246 smear-positive isolates, 212 (86%) had DST performed. Of these, 190 (90%) were from new and 22 (10%) from retreatment cases; 171 (81%) were from community and 41 (19%) were from prison patients. Any drug resistance was more common among prison than community patients (44% vs. 30%, P = 0.05). MDR-TB was found in 14 (6.6%) of 212 isolates, and was more prevalent in prison compared with community patients (12% vs. 5%, P = 0.05). Retreatment cases were more likely than new cases to have MDR-TB (prevalence ratio [PR] = 8.5, 95%CI = 3.3-22.3), although the PR was higher for prison than for community retreatment cases (10.0 vs. 5.8). CONCLUSIONS: New cases with MDR-TB were less prevalent in Orel Oblast compared with other survey sites in Russia. Any drug resistance and MDR-TB were associated with prior treatment, especially in the prison population. Continued monitoring of trends in drug resistance following DOTS implementation is needed.

Adult↗

Implications of the growing HIV-1 epidemic for tuberculosis control in Russia.

Orel oblast, Russia, is the site of a WHO demonstration project for tuberculosis control. We used data acquired by the Center for Prevention of AIDS and Infectious Diseases to show that, in this region, the seroprevalence of HIV-1 infection has increased 33-fold in 4 years. The rapid spread of HIV-1 in Russia has serious implications for control of tuberculosis epidemics. Although the HIV-1 epidemic is at an early stage, aggressive prevention measures must be taken quickly to avoid the adverse effects of widespread HIV on tuberculosis control that have been seen in sub-Saharan Africa.

AIDS-Related Opportunistic Infections↗

Effect of L-carnitine supplementation on performance parameters in gilts and sows.

The effect of L-carnitine supplementation during pregnancy and lactation on performance parameters of sows was studied. The trial comprised a total of 127 sows (40 gilts, 87 mature sows) which were divided into a control and a treatment group. All animals were fed individually and received basic feed mixtures for pregnancy and lactation with low carnitine concentrations (gestation diet: 4.7 mg/kg feed, lactation diet: 12.5 mg/kg feed). The rations of the sows in the treated group were supplemented with 125 mg L-carnitine per head and day during pregnancy and 250 mg L-carnitine per head and day during lactation. The animals of the control group received identical feed mixtures in identical amounts, but without the L-carnitine supplement. L-carnitine supplementation resulted in higher sow liveweight gains between day 1 and day 85 of pregnancy. The number of piglets per litter and the number born alive did not differ between the control sows and those treated with L-carnitine. However, the L-carnitine-supplemented sows produced only half as many non-viable piglets as the control animals. Moreover, litter weight and mean birth weight of piglets from L-carnitine-treated sows were higher than in the control sows. This effect was more marked in gilts (+8% higher litter weight, +9% higher piglet weight) than in sows (+7% and +6%, respectively). Piglets from sows whose ration was supplemented with L-carnitine showed higher liveweight gains during the suckling period (+12% for gilts, +4% for sows), which is why litter weights post weaning were also higher among the sows treated with L-carnitine than in the control sows (+14% for gilts, +10% for sows). Overall, the study shows that dietary supplementation with L-carnitine during pregnancy and lactation improves the reproductive performance of sows.

Animals↗

[Opinions of staff in the trial phase of standardized documentation of complementary psychiatric services].

A computerised standardised documentation system for non-hospital based psychiatric and psychosocial care is being developed in Saxony. A range of non-hospital based services was involved in the development process. Staff members were interviewed concerning their experience in using the documentation system. Results showed a critical appraisal by staff members, emphasising particularly (a) the investment of time required, and (b) the perceived usefulness of the documentation which was considered to be limited. Besides staff members feared that data protection issues might be disregarded and that data would be used to cut expenditure. Findings are compared with other studies assessing staff attitudes towards data collection in mental health services. It is concluded that the study adds to the existing evidence of staff scepticism towards computerised standardised documentation systems.

Adult↗