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Biomedical subjects

H Klosterhalfen

Publications and source records attributed to H Klosterhalfen.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Microsurgery in andrologic urology. I. Refertilization.

Of 30,000 men examined for impaired fertility from 1964 to the present, 900 were diagnosed as having excretory azoospermia. Of this number, 465 underwent surgery. Epididymovasostomy was performed on 316 men. For 11 years, this surgery was done with surgical loupes, and a patency rate of 48% was achieved in those men undergoing bilateral epididymovasostomy. (Only 52% of our patients showed inflammatory obstruction.) In a small series of patients undergoing the procedure under the operating microscope, a patency rate of 75% was achieved. Vasovasostomy was performed in 20 patients with loupes and splints. Patency was obtained in 11 of the 17 that were followed. Ten of 12 patients receiving anastomosis by a technique placing nonabsorbable sutures through the entire wall of the vas became fertile. Nine of 10 patients who were operated on by a double-layer technique under the operating microscope were found to have patent ducts at follow-up. The advances in microsurgical techniques, equipment, and suture materials have considerably improved the changes for refertilization.

Epididymis↗
PubMedDate not supplied

Effect of cyproterone acetate in comparison to flutamide on the ventral prostate of adult male castrated Copenhagen-Fisher rats and on Dunning R-3327 H tumors.

In this investigation the effect of CPA was tested in comparison to FL after the procedure of double blinding on the ventral prostate of 70 adult male castrated Copenhagen-Fisher rats and on the Dunning R-3327 H tumor. Total androgen blockade by castration plus CPA or by castration plus FL induced significant decrease in prostate weight compared to the androgen deprivation by castration alone. No significant difference between CPA and FL was observed. Furthermore it was impossible to exaggerate this effect with higher doses of CPA of FL. The Dunning R-3327 H tumor did not become palpable 60 days after inoculation of the tumor cells indicating that androgen deprivation by total androgen blockade by castration plus CPA or plus FL did not exhibit any proliferative activity on the hormone-sensitive Dunning R-3327 H tumor cells.

Androgen Antagonists↗