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Biomedical subjects

H Klinkmann

Publications and source records attributed to H Klinkmann.

At least 145 records · Page 8Linked to original sources
PubMed1983

Morphologic and functional tubular changes in chronic glomerulonephritis.

In 135 patients with different glomerular diseases but normal glomerular filtration rates (CCr and In = 103 +/- 2ml/min) correlations between morphological tubular lesions (tic) and changes in tubular function were investigated. Between the extent of tubular lesions and the impairment of specific tubular functions (formula; see text) exists a highly significant correlation. The combined diminution in Uosmmax and UNH4 + V reflects in 72 per cent the appearance of a severe tubular lesion and should be used for its clinical recognition.

Biopsy↗
PubMed1982

In vitro assessment of charcoal and resin hemoadsorbents.

An in vitro assessment has been made of the blood compatibility and efficiency of different charcoal and resin hemoadsorbents. The charcoals vary in source, shape, size, nature and amount of polymer coating. The resins are the macroreticular adsorbents XAD-4 and Y56 and a carbonized resin. The effect on Y56 of albumin coating has been studied. The assessment has demonstrated that a reduction in platelet drop is accompanied by a decrease in the adsorption of fibrinogen. The results confirm the potential advantages of spherical charcoal and that coating with an ultrathin layer of polymer or with albumin does not seriously reduce efficiency. For Y56 resin, treatment with an albumin solution of 1-2 g/100 ml appears to be a suitable procedure if clinical use is considered.

Antigen-Antibody Complex↗
PubMed1982

Cellular immunity in glomerulonephritis.

58 patients (25 with GN, 13 with PN, 10 with hypernephroma, and 10 healthy controls) were tested for t-cell activity against glomerular basement membrane antigen (GBMA), total renal antigen (TRA), hypernephroma antigen (HyA), HEP, and PPD by means of the electrophoretic mobility test described by Field and Caspary. Positive reactions to GMBA were demonstrated in 21 to 25 GN patients, and 2 of 13 PN patients. There was no reaction among the hypernephroma patients or the controls. Lymphocytes from all 10 hypernephroma patients, but only 1 of the other 37 patients tested, were sensitized against HyA. No conclusion may be drawn regarding the pathogenetic relevance of the findings, but attention is drawn to the diagnostic value of tests based on these results.

Adolescent↗
PubMed1982

[New aspects of steroid therapy of glomerulonephritis].

The results of a 6-month Prednisone therapy (initial 60 mg/d with later reduction of dose) are given as the immediate results of therapy (after 6 months in 128 patients) and as a late result (after 11 years in 107 patients). The course is evaluated on the basis of clinical symptoms. The early effect proved to be an improvement in 2/3 of all cases, whereby 22% were total remissions. In the late results patients with primary total remission showed the best functional results. This therapy is justified in nephrotic, proteinuric-hypertonic, purely proteinuric and proteinuric-haematuric forms of mesangioproliferative glomerulonephritis.

Adolescent↗
PubMed1982

Tc-99m-DTPA--a new test substance for detoxification devices.

Tc99m labeled diethylenetriaminepentaacetic acid (Tc-99m-DTPA) is an appropriate in vivo test solute for all extracorporeal detoxification procedures. The molecular weight of the Tc-99m-DTPA complex is within the biologically relevant middle molecular range of 400 to 700 daltons. Tc-99m-DTPA is distributed in the extracellular space in the same way as inulin. Regarding its localization in the gel filtration spectra and plasma clearance, Tc-99m-DTPA corresponds to middle molecule peak 2. The evaluation of elimination rate and plasma clearance CP of Tc-99m-DTPA is possible by measuring the pulse rates before and after the detoxification device. Taking into account the corrections for Ht and UFR, the Tc-99m-DTPA plasma clearances were calculated for different dialyzers, high flux dialyzers, hemofilters and a hemoperfusion device. The continuous measurement of pulse rates and the use of a UFR-controller (A2008) allow an exact tracking of CP vs. time, the estimation of CP (QB), CP(UFR) and of the sieving coefficient. Examples are given for these cases. It was shown that an increase in plasma clearance to more than about 100 ml/min does not greatly increase the Tc-99m-DTPA elimination rate.

Humans↗
PubMed1982

Volumetrically controlled ultrafiltration. Current experiences and future prospects.

Exact control of ultrafiltration (UF) is a prerequisite for high flux dialysis and hemodiafiltration. Volumetric dialysate balancing is the best current method for the use of dialyzers with high water permeabilities. The precision of UF control by volumetric dialysate balancing is in agreement with all medical requirements. A positive influence of volumetric UF control on patients undergoing chronic hemodialysis can be shown by the frequencies of dialysis side effects. Volumetric UF control is only a first step towards an intelligent UF module to correlate water removal, solute removal and sodium balance.

Body Water↗
PubMed1982

Assessment of mechanical properties and biocompatibility of Pellethane.

Pellethane CPR 2363-80A nonreinforced (PUR), non-reinforced and twice sterilized (PUR F2), reinforced with Dacron (Dm), Grisuten (DG) and glassfibre (PUG) and fabricated under different conditions have been examinated. Tests included uniaxial tension at 310 K, torsional movement from 293 to 319 K, X-ray structure, SEM, visual surface clotting, thrombocyte adhesion and degree of albumenisation. Typical in vitro results were: modulus of elasticity E [MPa] (PUR: 1.33, Dm: 4.22, DG: 1.86, PUG: 622.5), tensile strength delta B [MPa] (43.4, 12.5, 21.7, 24.9), elongation at break delta [%] (1122, 109, 660, 479), dynamic modulus of sliding G', G" [MPa] at 293 K (8.7, 0.4/ 15.9, 0.9/ 12.1, 1.3/ 17.1, 1.5), damping tan delta (0.13, 0.1, 0.16, 0.12), orientational degree at 5% elongation fx [%] (PUR: 0.5), low thrombogenicity and high degree of albumenisation. The results indicate a strong dependency of mechanical and biocompatibility properties on membrane and housing fabrication. The most effective combination is a thin PUR membrane and a PUG housing fabricated under special conditions.

Adhesiveness↗
PubMed1982

[Experiences with the Rostock artificial heart].

A totally artificial heart--the Rostock totally artificial heart (Rostock TAH) was implanted in calves. We can give the following deductions after 27 examinations: -- The Rostock TAH was tested successfully in endurance test about 7 months; it show no sign of wear. -- The surgical technique of the implantation was standardised and a successful experimentation is possible. -- The longest survival time was 15 days. The hemodynamic early results were very good in 3 other animals. -- Modifications of the Rostock TAH were taken up relating to the dimensions of the artificial ventriculi and by mounting a screw cap for avoiding an air embolism. -- Adaption tests in the corpse show that the present form of the artificial heart is not ideal for a possible application in man. -- The problem is still existing in developing a suitable drive system locates intrathoracically. The present drive and control system on a pneumatic base is qualified only for the animal experiment but not for a possible application in man.

Anesthesia, General↗
PubMed1981

[The electrophoresis mobility test (EMT) in the immunologic after care of patients with kidney transplantations].

Of 80 recipients of kidney transplants 46 patients could after operation immunologically be controlled by means of the electrophoresis mobility test. Here a good correlation to the clinically observed or not established immune responses was shown. The method seems to be suitable for a postoperative immunological control, needs, however, a testing in a great number of patients.

Erythrocytes↗
PubMed1981

Continuous measurement of DTPA-clearance in extracorporeal detoxification circuits.

A new method for investigating clearances is described. DTPA labelled with technetium 99m (MW: 496 daltons) is used as an agent to be measured. Continuous determination of the DTPA-clearance is possible in extracorporeal detoxification circuits including dialyzers, hemofilters and hemoperfusion columns. As an example, DTPA-clearances are given for two different dialyzers. In comparison to clearance measurements of peak 7, DTPA-clearance was very similar to that obtained for peak 7.

Autoanalysis↗
PubMed1980

[Developmental tendencies of hemadsorption in uremia treatment].

After at first having dealt with the present stage of haemoperfusion in the therapy of chronic renal insufficiency, the developmental tendencies for the haemoadsorbers to be expected are mentioned which in future allow to think of a diminution of the artificial kidney. Own results concerning the behaviour of blood compatibility and the effectivity of different active charcoals show that it is to be reckoned with the further development of unstratified adsorbents or such ones with ultra-thin layer. Comparative examinations of 4 patients from the chronic haemodialytic programme, who were treated for 4 months with the CDAK 1.8 and then for 4 months with the sorbent dialyser 1.3, could not show any essential differences in the behaviour of the low-molecular substances urea, creatinine and uric acid and of the clinical condition of the patients.

Creatinine↗
PubMed1980

[Blood detoxication procedures in extra-renal diseases].

In a survey concerning the application of haemodialysis, ultrafiltration, haemofiltration, haemoperfusion and separation of plasma in the treatment of non-renal diseases clinically tested methods are discussed. The therapy of endogenic and exogenic poisonings as well as the removal of hyperhydrations of different genesis using extracorporeal systems can be clarified scientifically with the help of clinical course and laboratory findings. The separation of plasma on membrane opens new possibilities of therapy of above all immunologically conditioned diseases. The valency of the treatment of schizophrenia needs further intensive research concerning etiology and pathogenesis, since the judgment of the success of therapy still underlies too many subjective factors.

Anemia, Sickle Cell↗