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Biomedical subjects

H Klinkmann

Publications and source records attributed to H Klinkmann.

203 records · Page 12Linked to original sources
PubMedDate not supplied

In vitro studies with selectively lipid adsorbing materials.

A new synthetic material was developed by ASAHI Chemical Industry Co., Ltd., Tokyo, Japan. In vitro studies revealed selective bindings of cholesterol, LDL (low density lipids) and beta-lipoprotein by this material. Maximal bindings were reached within 1 min, and therefore, the affinities of the LDL-adsorbent to these lipid components seem to be high. In contrast to these results the plasma values of HDL (high density lipids) and apoprotein A remained nearly unchanged. Triglycerides were removed only moderately. Investigations about lipid removing capacity of the new material with the plasma of patient with familiar hypercholesterolemia and studies about interactions with the complement system were also promising. Synthetic materials which are under development in G.D.R. showed similar lipid binding capacities.

Acrylic Resins↗
PubMedDate not supplied

Basic concept for implantation technique of total artificial heart in humans: a review from cadaver implantations.

To develop the application technique of the total artificial heart in humans, it is important to establish a concept about the implantation procedures. Based on cadaver experiments with various types of prosthetic ventricles, some aspects in solving the surgical difficulties were described. Special interest was directed to the geometric topography, the optimal design of the prosthetic ventricles, and the possible surgical solution. Under consideration of spatial differences, especially from that of experimental animals, a proposal was made to place the left and right artificial ventricle with the goal of avoiding compression of the inflow tract or obstruction of the outflow. The design of the connection parts and the angles of the inflow and outflow tracts of the artificial ventricles is essential for good results.

Cadaver↗
PubMedDate not supplied

[Changes in the picture of chronic diseases on long-term hemodialysis treatment].

New data published in the literature provided evidence for appearance of an unknown variant of amyloidosis recorded in patients with a 5-15-year history of hemodialysis. Such amyloidosis may result from high blood levels of beta-2-microglobulin unremovable at standard hemodialysis. Even highly permeable membranes which permit beta-2-microglobulin penetration fail to produce negative balance of this metabolite as the procedure stimulates leukocyte activity and, consequently, beta-2-microglobulin production. In spite of the fact that contact of the blood with synthetic materials during hemodialysis is not longer than 3-5 hours, blood elements and endothelial cell metabolism, homeostasis undergo serious alterations. These effects of biocompatibility provoke the condition of enhanced activation similar to chronic inflammation. Thus, we deal with a new phenomenon in the field of hemodialysis. The efforts of investigators should be aimed at studying long-term adaptation of the body which rings atypical picture of chronic diseases.

Amyloidosis↗