Late recurrence of renal cell carcinoma (RCC), arbitrarily defined as > 10 years post nephrectomy, is rare. The longest known clinical disease-free interval of 36 years was reported by Walter and Gellespie in 1960. We report a case of recurrent RCC presenting 45 years after nephrectomy.

Aged↗

PubMedDate not supplied

Use of DNA repair-deficient XPA transgenic mice in short-term carcinogenicity testing.

At present (putative) human carcinogens are identified via epidemiological studies and testing using the chronic 2-yr rodent bioassay. Both methods have severe limitations in that they are slow, insensitive, expensive, and are also hampered by many uncertainties. The development of methods to modify specific genes in the mammalian genome has provided promising new tools for use in identifying carcinogens and characterizing their (qualitative) risk. Several transgenic mouse lines are currently under study to test their possible use in short-term carcinogenicity testing. One such candidate alternative transgenic model is the XPA knock-out mouse. These mice have an almost complete deficiency in DNA nucleotide excision repair (NER). Nevertheless, XPA-deficient mice are viable and have a background of a low incidence of spontaneous development of cancers. Approximately 15% of the mice develop hepatocellular adenomas (only after 1.5 yr). After treatment with ultraviolet-B radiation or 7,12-dimethylbenz(a)anthracene, the XPA-deficient mice developed squamous cell carcinomas and papillomas, respectively, on their skin. Oral treatment of XPA-deficient mice with benzo[a]pyrene (B[a]P), 2-acetylaminofluorene (2-AAF), and 2-amino-1-methyl-6-phenylimidazo [4,5-b]-pyridine (PhIP) resulted in lymphomas (B[a]P), liver and bladder tumors (2-AAF), and intestinal adenomas plus lymphomas (PhIP). These results look encouraging, but it should be noted that the compounds and agents tested thus far have all been substrate for nucleotide excision repair. Animal studies with different genotoxic or nongenotoxic compounds, as organized for instance within the framework of the International Life Sciences Institute/Health and Environmental Sciences Institute program, are needed to further evaluate the suitability of the XPA model for short-term carcinogenicity testing.

Animals↗

PubMedDate not supplied

Ampicillin and propylthiouracil pharmacokinetics in intestinal bypass patients followed up to a year after operation.

The pharmacokinetics of ampicillin and prophylthiouracil were studied in 6 and 9 patients, respectively, before and several times up to a year after a shunt operation for extreme obesity. The drugs were given intravenously and orally making it possible to estimate the absolute bioavailability. The bioavailability of propylthiouracil (about 80%) was unchanged by the surgical procedure but the fraction of ampicillin (given as pivampicillin) absorbed decreased from a preoperative value of 109 +/- 44% to 44 +/- 30% 12 months after the bypass operation. Volumes of distribution transiently decreased in the postoperative period for ampicillin. Clearance was initially reduced for both ampicillin and propylthiouracil after operation but returned to normal values a year later. Half-lives of both drugs were unchanged. These results are compared with previous data on pharmacokinetics in intestinal shunt patients and a tabular review is presented. Although no general rules presently emerge from the data available, it seems prudent to closely monitor intestinal shunt patients on drug therapy by both laboratory and clinical methods.

Adult↗

PubMedDate not supplied

Root resorption of primary molars: a radiographic study.

Explore the source record for details and available documents.

Adolescent↗

PubMedDate not supplied

Assessment of a 2 percent buffered glutaraldehyde solution in pulpotomized primary teeth of schoolchildren.

This investigation was undertaken, clinically and radiographically, to assess the effect of glutaraldehyde as a pulp medicament in pulpotomized cariously exposed primary molars. Fifty-three primary molars of thirty-two second-grade children were evaluated after being treated by pulpotomy utilizing a 2 percent buffered glutaraldehyde solution. Failures were observed in 5.7 percent of the teeth at the six-month evaluation and increased with time: 9.6 percent after 12 months; and 18 percent after 25 months. Internal resorption was observed in six teeth; external resorption was found in only one tooth. Pulp canal obliteration, which was not listed as a failure, was observed in one tooth after 6 months, yielding a total of twenty teeth at the final examination. In thirty-eight pulpotomized teeth (82.6 percent), the resorption rate was similar to their antimeres; in another seven, root resorption was faster; and only one pulpotomized tooth resorbed more slowly than its antimere. The relatively high failure rate in the present study does not justify recommending a 2 percent buffered glutaraldehyde solution as a substitute to formocresol.

Child↗

PubMedDate not supplied

Transcutaneous bilirubinometer: an instrument for clinical research.

The transcutaneous bilirubinometer can be an effective instrument for clinical research. With neonatal jaundice occurring in approximately 50-75% of newborns, nurse researchers investigating many important issues surrounding this commonly occurring condition will find the bilirubinometer useful in screening for jaundice, testing effectiveness of various therapeutic modalities, and evaluating clinical progress. This article presents a review of the literature reporting reliability and validity of meter findings and makes recommendations for meter use.

Bilirubin↗

PubMedDate not supplied

Effect of cyproterone acetate in comparison to flutamide on the ventral prostate of adult male castrated Copenhagen-Fisher rats and on Dunning R-3327 H tumors.

In this investigation the effect of CPA was tested in comparison to FL after the procedure of double blinding on the ventral prostate of 70 adult male castrated Copenhagen-Fisher rats and on the Dunning R-3327 H tumor. Total androgen blockade by castration plus CPA or by castration plus FL induced significant decrease in prostate weight compared to the androgen deprivation by castration alone. No significant difference between CPA and FL was observed. Furthermore it was impossible to exaggerate this effect with higher doses of CPA of FL. The Dunning R-3327 H tumor did not become palpable 60 days after inoculation of the tumor cells indicating that androgen deprivation by total androgen blockade by castration plus CPA or plus FL did not exhibit any proliferative activity on the hormone-sensitive Dunning R-3327 H tumor cells.

Androgen Antagonists↗