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Biomedical subjects

H King

Publications and source records attributed to H King.

At least 163 records · Page 9Linked to original sources
PubMed1980

Isolation of a morphologically-transformed epithelial cell-line from rat kidney following an in vivo dose of dimethylnitrosamine.

In an in vivo-in vitro system, a rat kidney epithelial cell-line was isolated into continuous culture 48 h after a single administration intraperitoneally of dimethylnitrosamine (DMN). The dose used, 60 mg/kg, was known to induce approximately a 40% incidence of renal cortical epithelial umors, in addition to a much higher incidence of renal mesenchymal tumors. The cell-line was established from several persisting islands of epithelial cells which were cultured in Leibowitz medium supplemented with various-growth enhancing agents and periodically, the antifibroblastic agent cishydroxyprolin. Through succeeding subcultures, the cells retained an epithelial morphology and at confluence piled-up into 3-dimensional ridges and domes above the monolayer. The cells were characterized by continuous growth in culture, the ability to form colonies at very low seeding rates, loss of anchorage-dependence as determined by growth in semi-solid media and formation of multicellular aggregates in suspension culture, and agglutination in the presence of conconavalin A. These altered properties of growth and behavior indicate that the renal epithelial cells constitute a morphologically transformed line. As such, they may represent the same target cell population from which DMN-induced epithelial tumors arise in the rat kidney.

Animals↗
PubMed1980

Improved results in newborns undergoing coarctation repair.

Among 172 children who underwent repair of coarctation of the thoracic aorta from June 1, 1967, to June 1, 1979, there were 50 who were less than 6 weeks old. A review was undertaken to assess mortality and postoperative residual hypertension in this newborn age group. Forty-five (90%) had one or more associated congenital cardiac lesions, which were repaired or paliated at the time of coarctation repair. The three most common associated lesions were patent ductus arteriosus (74%), atrial septal defect (74%), and ventricular septal defect (62%). Thirty-one newborns underwent resection with parimary end-to-end repair with 8 deaths (26%), and 18 underwent Dacron patch angioplasty and 1 underwent subclavian angioplasty with 4 deaths (21%). Of the 38 survivors, 36 (95%) had good pedal pulses on postoperative clinical examination 3 months to eleven years postoperatively. Seventeen (45%) had upper and lower extremity blood pressure measured; 2 (5%) showed residual upper extremity hypertension (greater than 2 standard deviations above the mean and a gradient less than 20 mm Hg). One of these 2 patients has undergone repeat repair. Based on this low mortality and infrequent need for repeat repair, we advocate aggressive early operation and judicious use of palliative procedures in newborns, when indicated, for associated defects.

Aorta, Thoracic↗
PubMed1980

Intraoperative assessment of the mitral valve following reconstructive procedures.

A technique facilitating intraoperative assessment of the degree of mitral insufficiency during and after mitral reconstructive procedures has been developed. A multiholed left ventricular vent catheter is advanced across the aortic valve, thereby creating aortic insufficiency, filling the left ventricle with blood at aortic perfusion pressure, and approximating the leaflets of the mitral valve in the closed position. If present, mitral insufficiency can be estimated by the size of the regurgitant jet. In addition to assessing valve function following open mitral valvotomy, the method has also been helpful in managing leaks around the prosthetic valve, in assessing the closure of cleft mitral valve leaflets associated with ostium primum atrial septal defects, in confirming the completeness of closure, and in detecting obscure ventricular septal defects.

Humans↗
PubMed1980

American white Protestant clergy as a low-risk population for mortality research.

An examination of 28,134 clergymen in five predominantly white Protestant denominations, 1950--60, showed a more favorable mortality for these clergymen for all causes of deaths, total cancers, and cardiovascular-renal diseases compared with the mortality for U.S. white males, total U.S. males with work experience, and total U.S. white clergymen. The standardized mortality ratios for cancer of the lung and non-motor-vehicle accidents were particularly depressed. However, those for diabetes, leukemia, and cancers of the prostate gland and, to a lesser extent, lymphoma and cancers of the intestine and pancreas were not significantly different from 100. The findings were interpreted in the social class contest, with emphasis on cross-national investigations and critical assessment of clerical statistics.

Adolescent↗
PubMed1980

Cancer mortality among Chinese in the United States.

A total of 1,824 cancer deaths among the Chinese in California, Hawaii, and New York City, 1968--72, was examined against 96,635 Taiwanese dying from cancer for the corresponding years. Emphasis was placed on patterns of displacement by nativity between 1960 and 1970. Much of the transitional experiences were similar to those reported for Japanese and European migrants to the United States, such as the rise of cancers of the lung and colon in males. However, the upward displacement of cancers of the female breast and corpus uteri failed to occur among the Chinese. In general, the pattern of transition for Idai and Erdai was less apparent, compared with the mortality experiences of Issei and Nisei. Perhaps longer periods are needed to achieve full displacement of cancer risks in the advanced ages.

Adolescent↗
PubMed1980

Cancer mortality risk among Japanese in the United States.

Earlier findings on cancer mortality experiences of Nisei and Issei were updated to around 1970. Compared with U.S. whites, Japanese in Japan had a high standardized mortality ratio (SMR) for cancers of the esophagus, stomach, biliary passages, and cervix, whereas they had low ratios for cancers of most other sites. Among U.S. Japanese, the direction and magnitude of the SMR transition varied by site, but generally the SMR moderated toward that of U.S. whites. Specifically, mortality from stomach cancer was elevated through the ratio has been reduced. In addition, mortality from cancers of the liver and biliary passages remained high. In contrast to a sharp decline in the SMR for esophageal cancer, the SMR for cancer of the colon and lymphomas rose closer to the levels for whites. The SMR for cancers of the ovary and prostate gland represented a rise above that of Japan. A higher Issei than Nisei SMR was observed for most cancer sites, regardless of the risk level in Japan. The reverse was true for cancers of the liver and nasopharynx among males, cancers of the breast and ovary among females, and lymphosarcoma and leukemia among both sexes.

Adolescent↗
PubMed1980

Tetralogy of Fallot with abnormal coronary artery: 1967 to 1977.

From 1967 to 1977, 25 of 250 children undergoing complete repair of tetralogy of Fallot had an abnormal coronary artery identified at operation. Eight (Group 1) had classical anomalous coronary artery, and 17 (Group 2) had a large aberrant artery in addition to a smaller, normally positioned artery. All 25 patients required surgical procedures different from those routinely employed in tetralogy of Fallot repair. These included a "tailored" ventriculotomy, double incision, and accessory right ventricle-to-pulmonary artery conduit. After identification of a parallel (smaller) coronary artery, the anomalous coronary artery was ligated in three. Two patients (Group 2) died following the operation, both with "tailored" incisions. These were two of the four with high residual right ventricular pressure. Survivors have done well clinically for at least 1 year. Postoperative catheterization has shown high residual right ventricular pressure in two patients and an insignificant residual ventricular septal defect in four patients none has required reoperation.

Cineangiography↗
PubMed1977

Florid epithelioid cell and sarcoid-type reaction associated with non-Hodgkin's lymphoma.

Five patients suffering from non-Hodgkin's lymphoma associated with an intense infiltration of epithelioid histiocytes and even sarcoid-type granulomas in the involved tissue are described. A similar tissue reaction, at both involved and uninvolved sites, has been described in patients with Hodgkin's disease. The cause of this reaction may be immunological; its prognostic significance still awaits elucidation. In the case of non-Hodgkin's lymphomas, it may cause difficulty in diagnosis of lymphoma and hence may result in unnecessary delay in the initiation of therapy.

Adult↗
PubMed1977

Loeffler's endocarditis presenting as mitral and tricuspid stenosis.

Loeffler's endocarditis characteristically produces cardiac dysfunction by the combined effects of endocardial fibrosis with restriction to diastolic inflow and intracavitary thrombosis with partial cavity obiliteration. Although valve dysfunction may complicate this condition, it is rarely of primary hemodynamic significance. This report describes an unusual case in which mitral and tricuspid stenosis were the primary cardiac lesions. Because of the critical nature of the valve stenosis, surgical intervention was attempted despite evidence of left ventricular involvement. This case suggests than when significant valve dysfunction complicates Loeffler's endocarditis, surgical revision may be undertaken with at least temporary amelioration of the valve disorder and without apparent adverse effect on the underlying disease process.

Adult↗
PubMed1977

Lymphoma of the skin. A comparative clinico-pathologic study of 50 cases including mycosis fungoides and primary and secondary cutaneous lymphoma.

A clinico-pathologic study of lymphomas of the skin included 14 cases of mycosis fungoides, 14 of primary lymphoma and 22 of secondary lymphoma. Mycosis fungoides has clinical and histopathologic features which allow for separation from the other groups. In this study, patients with mycosis fungoides had a longer duration of history and presented with papules, plaques, erythroderma or generalized dermatitis but not with tumor nodules ab initio. A confident histologic diagnosis required the presence of the mycosis cell, which was usually present in association with a mixed inflammatory cell infiltrate. Another important histologic feature was the presence of invasion of the epidermis by the mycosis cells singly and/or in nests (Pautrier microabscesses). Primary and secondary lymphomas of the skin presented clinically as multiple tumor nodules and histologically as a monomorphic infiltrate of neoplastic cells confined to the dermis and subcutis. A feature which has not been adequately documented in a large series was the presence of an associated prominent epithelioid cell reaction in several cases from all three groups.

Female↗