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Biomedical subjects

H Kikuchi

Publications and source records attributed to H Kikuchi.

At least 847 records · Page 47Linked to original sources
PubMed1983

[Embolization and detached balloon occlusion by the femoral route in craniofacial lesions].

Embolization and detached balloon occlusion by the femoral route were performed in 45 cases: 19 cases of meningiomas, 5 of scalp arteriovenous malformations (AVMs), 4 of dural AVMs, 6 of cerebral AVMs, 8 of facial angiomas and 3 of carotid cavernous sinus fistulas (CCFs); and favorable results were attained. In meningiomas, there is only a short interval between the embolization and the removal of tumor (we usually perform the embolization a couple of days before the removal), and we use Gelfoam as embolus material. We aim at central tumor embolization with small emboli. The embolization reduced bleeding in removing the tumors, simplifying the surgical procedure, and 12 of 19 cases required no blood transfusion. Almost all cases of scalp AVMs, dural AVMs and facial angiomas could most probably be cured only by the embolization without surgery. Gelfoam was the first choice, because it would probably dissolve, and also because it would be relatively safe even if pulmonary embolism might occur as a result of probable passage of its emboli onto the venous side. In recanalized cases, the embolization was performed again with Ivalon, a permanent embolus material. The most important of this procedure is to inject the emboli of the suitable size for each case together with a suitable contrast material at as low a rate as possible under the image intensifier. Embolization by the injection pressure should never be tried, but the emboli be allowed to be carried only on the blood flow to the distal side. And the embolization should be discontinued at the stage when the contrast material has stagnated. CCFs are very good indications for the detached balloon occlusion, while this technic proved to serve for no more than occluding the feeding vessels in cerebral AVMs; in other words, it is indicated in a rather limited range of AVMs. We have encountered no severe complications in any of the cases treated by the embolization and detached balloon occlusion.

Adolescent↗
PubMed1983

[Multilocular encapsulated intracerebral hematoma].

Encapsulated intracerebral hematoma is so rarely seen that only two cases have been reported, by Hirsh et al. Recently, we experienced a case of multilocular encapsulated intracerebral hematoma containing 9 to 10 capsules of different sizes. The capsules of the hematoma were easily dissected from the surrounding brain tissues and found to be grayish white in color, tough in hardness and 1 to 3 mm in thickness. The capsular contents ranged from very old to relatively new, which contents were hard on soft solid hematomas, liquid hematomas or xanthochromic fluid. These findings indicated the development of intracerebral hematomas with different chronic courses at different times. It is very interesting that the frequency of the convulsive seizure was almost consistent with the number of capsules. For etiology of multilocular intracerebral hematoma, either occult vascular malformation or bleeding from the sinusoidal channel layer of the capsules like that of chronic subdural hematoma is considered.

Cerebral Hemorrhage↗
PubMed1982

Preferential modification of the inverted repeat DNA of tetrahymena by N-methyl-N'-nitro-N-nitrosoguanidine.

DNA was prepared from Tetrahymena pyriformis, that was cultured for 2 h in medium containing chemical carcinogens. After denaturation of DNA in alkaline solution, DNA was quickly renatured below 10(-3) Cot and the double-strand DNA (the inverted repeat DNA) was separated from the single-strand DNA on a column of hydroxyapatite. N-Methyl-N' -nitro-N-nitrosoguanidine and methyl methanesulfonate preferentially bound in vivo to the inverted repeat DNA rather than other DNA components which were recovered as single-strand DNA.

Animals↗
PubMed1982

[Monitoring system of cerebral blood flow and cerebral metabolism. Part II. Relationship between internal jugular O2 tention and cerebral blood flow (author's transl)].

Changes of PjO2 values of internal jugular vein were monitored in patients with various types of cerebrovascular disease. The significance of PjO2 monitoring was evaluated. 1) Control value of PjO2 in thirteen normal control cases was 36.7 +/- 1.9 mmHg (mean +/- SD). 2) Limit of brain hypoxia showing no neurological sign and symptom in patients with occlusive cerebrovascular disease was studied by the stepwise reduction of arterial blood pressure, using drip infusion of trymetaphan camsylate, under the careful monitoring of signs and symptoms and monitoring of PjO2 and EEG. Appearance of signs and symptoms of brain hypoxia were checked by yawning and EEG slowing. At the time of the appearance of brain hypoxia PjO2 was 28.6 +/- 3.2 mmHg. 3) CO2 reactivity of CBF was studied in patients with occlusive cerebrovascular disease. Relation between PaCO2 and PjO2 was as follows; PjO2 = 0.68 . PaCO2 + 7.55 4) Within 24 hours after the onset of stroke, ipsilateral PjO2 of the cases with disturbance of consciousness was lower than that of the cases without disturbance of consciousness, which might indicate the significant decrease of CBF in the former cases. During 3rd to 7th day after the onset the cases with disturbance of consciousness showed the significant elevation of PjO2, which might indicate the reduction of cerebral metabolism. 5) The elevation of ipsilateral PjO2 were well correlated to the degree of hemispheric brain swelling. 6) During general convulsion, high level of PjO2 values were observed. 7) PjO2 values were inversely correlated to the hemoglobin values after blood transfusion, which was mainly due to the decrease of CBF by high content of hemoglobin.

Adult↗
PubMed1982

[Experiences with intravenous drip infusion therapy of amikacin for severe infections in patients of hematological disorder].

Amikacin was studied for clinical effect in 7 patients with acute leukemia, 1 patient with chronic myelogenous leukemia-blastic crisis, 1 patient with malignant lymphoma and 1 patient with aplastic anemia, who were suffered from severe infection such as sepsis, pneumonia or subcutaneous abscess. Most of these patients had bleeding tendency, so amikacin was administered by intravenous drip infusion in a dose of 200 mg--400 mg for 1 hour. Total doses of amikacin were between 3.2 g and 12.6 g. These doses of amikacin gave good response to 3 patients with sepsis, 1 patient with subcutaneous abscess and 1 patient with pneumonia. We didn't observe any side effect most likely associated with amikacin. Therefore, intravenous drip administration of amikacin might be useful drug for management of severe infections in patients of hematological disorder, and seemed to be as safe as intramuscular administration.

Adolescent↗