Biomedical subjects

H Kaya

Publications and source records attributed to H Kaya.

113 records · Page 7Linked to original sources

PubMedDate not supplied

Gamma probe-guided surgery for revision thyroidectomy: in comparison with conventional technique.

Reoperative thyroid surgery may be required in patients who undergo any procedure less than total or near total thyroidectomy. The aim of this study was to investigate advantages of gamma-probe guided revision thyroidectomy (GGRT) over conventional revision thyroidectomy (CRT) in patients with differentiated thyroid carcinoma (DTC). GGRT was assessed according to the TSH values, complication rates and the incidence of carcinoma in residual thyroid tissue. In this randomised prospective clinical trial, 25 patients with differentiated thyroid carcinoma who had previously undergone surgery for benign multinodular goiter were included in the study. GGRT was performed in 11 (44%) patients (Group 1) and CRT in 14 (65%) (Group 2). The intraoperative mean ratio of thyroid activity to background activity (T/B) was detected as 5.1 +/- 1.4 and the mean ratio of thyroid bed activity to background activity after excision (Tbed/B) was 1.3 +/- 0.3, (p < 0.01). Although the incidence of carcinoma in residual thyroid tissue was higher in group 1 (4/11) in comparison to group 2 (1/14), it was not statistically significant. The elevation of the TSH concentration at the first post-operative month was significantly higher in group 1 in comparison with group 2 (18 +/- 25 5 +/- 3 mlU/l), (p < 0.02). These results indicate that intraoperative gamma probe application may be beneficial to detect and remove residual thyroid tissue in revision thyroidectomy.

Adult↗

PubMedDate not supplied

Familial nephrotic syndrome with focal glomerular sclerosis.

Two brothers with nephrotic syndrome are reported. Their parents were first cousins. The nephrotic syndrome developed at the age of 14 and 15 years and was resistant to the treatment with corticosteroid. The elder patient fell into renal failure about 2-1/2 years after the development of nephrotic syndrome, and the younger has demonstrated a progressive decrease in renal function. The renal histopathology in one patient revealed findings typical of focal glomerular sclerosis. In light of the clinical similarities in these two patients, it is likely that they have a familial form of focal glomerular sclerosis.

Adolescent↗

PubMedDate not supplied

Blood reflux into cartridges for dental anesthesia: detection in residual solution.

The study examines blood reflux into cartridges under infiltration anesthesia. When imitation examination was carried out using Pontamine blue dye solution in 7 kinds of syringes using cartridges, dye reflux was observed in all of them. Dye reflux was observed in all but 1 of 4 kinds of cartridges on the market. The amounts of protein in residual anesthetic solution of cartridges after infiltration anesthesia were quantitatively measured by a dye binding method. Human hemoglobin was also measured by enzyme immunoassay (EIA). The detection rates of protein and human hemoglobin were 26.2% (85/324) and 24.2% (24/99), respectively. Study results show that blood reflux cannot be avoided in the cartridge system so reuse of residual anesthetic solution from cartridges should be prohibited as quickly as possible to avert risk of cross-infection of HB and AIDS virus.

Anesthesia, Dental↗

PubMedDate not supplied

Comparison of xenografting in SCID mice and LIVE/DEAD assay as a predictor of the developmental potential of cryopreserved ovarian tissue.

This study compared the predictive value of the LIVE/DEAD fluorescence viability assay to xenotransplantation in SCID mice, regarding the developmental potential of cryopreseved human ovarian tissue for fertility preservation purposes. The thawed ovarian tissue of ten patients was partly examined by LIVE/DEAD viability staining or histologically examined after transplantation and gonadotropin stimulation in 30 SCID mice. The LIVEIDEAD assay showed 87.1 +/- 3.5% (mean +/-SD, n=10) viable follicles (intact oocyte and more than 50% of granulosa cells alive). Histological examination showed follicles in all developmental stages in the transplanted grafts. The total number of follicles found was much lower than with the LIVE/DEAD assay (8.9 +/- 3.1 versus 54.4 +/- 20.0, p < 0.001). If the LIVE/DEAD assay yields > approximately 85% viable follicles, it can be assumed that the follicles in the cryopreserved tissue have maintained their developmental potential. This assay is, therefore, a suitable diagnostic method before an intended retransplantation.

Adolescent↗

PubMedDate not supplied

Autoregulation of histamine release via the histamine H3 receptor on mast cells in the rat skin.

The autoregulation of the histamine release via the histamine H3 receptor in the periphery was studied in vivo and in vitro. Antidromic electrical stimulation of the sciatic nerve caused a significant increase in histamine release in the subcutaneous perfusate in the rat hindpaw. (R)alpha-methylhistamine, a specific H3 receptor agonist, significantly and dose-dependently inhibited the increase in release of histamine by antidromic stimulation at intravenous doses of 0.25-2 mg/kg. Thioperamide (2 mg/kg, intraperitoneally), a specific H3 antagonist, prevented the inhibitory effect of (R)alpha-methylhistamine. Substance P perfusion (5-50 microM) also elicited a significant increase in histamine, and a significant inhibition by (R)alpha-methylhistamine and the antagonism of thioperamide were observed. (R)alpha-methylhistamine inhibited the histamine release by substance P from rat peritoneal mast cells in vitro, and thioperamide reduced the response to (R)alpha-methylhistamine. These data suggest that mast cells may have histamine H3 receptors, and that histamine probably modulates its own release through the H3 receptor in neurogenic inflammation.

Analysis of Variance↗