Search PubMed⌕ Search

Biomedical subjects

H Kavin

Publications and source records attributed to H Kavin.

At least 19 recordsLinked to original sources
PubMed1992

Management of perforation of the colon at colonoscopy.

We propose guidelines for the management of perforation of the colon at colonoscopy based upon a comprehensive literature review. Conservative management is advocated for silent perforations and in patients with mild or localized symptoms and signs diagnosed within 4-8 h of injury. Perforations diagnosed late may be managed by nonoperative methods, if the infection is confined as determined clinically or by imaging techniques. A suspected large perforation, generalized peritonitis, or failure to improve on conservative management will mandate surgical exploration. In an intermediate group of patients, decisions regarding management will depend on crucial information regarding the circumstances surrounding the procedure. These include the endoscopist's assessment of the size, mechanism, and timing of the perforation, the adequacy of bowel preparation, delay time to diagnosis, overall condition of the patient, and the presence or absence of associated colonic pathology. Antibiotic therapy should be given to all patients immediately upon diagnosis. Single-agent therapy with cefoxitin can be used in the immunocompetent patient. Under other circumstances, combination antibiotic treatment is indicated.

Colon↗
PubMed1987

Identification of isoprenoid-type components in human expired air: a possible shunt pathway in sterol metabolism.

Expired air samples have been analyzed from three groups of human subjects (normal, liver dysfunction, lung cancer) and the baboon (Papio anubus). Of the several hundred compounds present, three compounds were of particular interest due to their structural relationship to the isoprenoid-type intermediates in the sterol pathway. These compounds were 1-methyl-4-(1-methyl-ethenyl)-cyclohexene, 6-methyl-5-hepten-2-one, and 6,10-dimethyl-5,9-undecadien-2-one. Hydroxyacetone was also found in all samples screened. The relationship of these compounds to the non-sterol pathway of mevalonate metabolism is discussed.

Animals↗
PubMed1987

Influence of long-term aldose reductase inhibitor therapy on autonomic dysfunction of urinary bladder, stomach and cardiovascular systems in diabetic patients.

The effects of the aldose reductase inhibitor (ARI) sorbinil (250 mg/day) were tested in an open-label pilot study over 1 year, in eight diabetics with peripheral neuropathy, seven of whom had symptomic autonomic neuropathy (AN). Autonomic function studies of the urinary bladder, stomach and cardiovascular system were performed at baseline, 6 and 12 months. Six patients reported improvement in symptoms of AN by 6 months which was maintained or further improved by 12 months. Bladder sensation, as measured by cystometrographic parameters, improved at 6 months (P less than 0.02- less than 0.04), but by 12 months had reverted to baseline. Residual urine volume decreased at 6 months (P less than 0.06) and 12 months (P less than 0.06). Vagally mediated gastric acid secretion improved at 6 months (P less than 0.06); the subgroup of patients with subnormal secretion showed improvement to the normal range at 6 months (P less than 0.03). Gastric emptying of solid food was normal in six of eight subjects and showed no significant change at 6 months. Both patients with delayed emptying normalized. No change in beat-to-beat variability in heart rate with respiration was noted. Resting minimum heart rate decreased at 12 months (P less than 0.05). Glycohemoglobin levels showed no statistically significant changes. No toxic reactions were observed. These data suggest a beneficial effect of ARI treatment on symptomatic and asymptomatic manifestations of diabetic autonomic neuropathy and indicate a need for large controlled trials.

Adult↗
PubMed1983

IgA deposits in skin in alcoholic liver disease.

IgA deposition in the liver in a characteristic continuous pattern is a consistent finding confirming the diagnosis of alcoholic liver disease. This study demonstrates a correlation between characteristic IgA deposition in the liver and IgA deposition in and around superficial dermal capillaries in alcoholic liver disease. Simultaneous liver and skin biopsies from nineteen patients with established alcoholic liver disease and eight patients with nonalcohol-related diseases of the liver were studied using standard immunofluorescent and immunoperoxidase methods. Fourteen of the nineteen alcoholic patients showed the characteristic pattern of IgA deposition in the liver, twelve of these fourteen patients showed IgA deposits in and around superficial dermal capillaries, and of these twelve patients, nine showed concurrent deposits of C3 in the skin capillaries. None of the eight nonalcoholic control patients showed either characteristic liver IgA deposits or any dermal deposits. Biopsy of clinically normal skin can be of adjunctive aid in the confirmation of alcoholic liver disease.

Biopsy↗