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Biomedical subjects

H Kaufman

Publications and source records attributed to H Kaufman.

At least 109 records · Page 6Linked to original sources
PubMed1976

Beclomethasone dipropionate and chronic asthma. The effect of long-term aerosol administration on the hypothalamic-pituitary-adrenal axis after substitution for oral therapy with corticosteroids.

Beclomethasone dipropionate aerosol at a dose of 100 mug four times a day was administered to 32 patients suffering from chronic perennial asthma. Twenty-three of these patients had previously received prolonged treatment with corticosteroids, causing various degrees of adrenal suppression in some patients. Almost complete recovery of adrenal function was observed within a period of six months in most patients. Treatment with beclomethasone dipropionate did not affect the hypothalamic-pituitary-adrenal axis in the other nine asthmatic patients who had not received prolonged corticosteroid therapy previously and who served as a control group.

Administration, Oral↗
PubMed1976

Response to LH-RH and HCG in two brothers with the Reifenstein syndrome.

Two brothers with Reifenstein syndrome underwent LH-RH and HCG tests at various ages ranging from 13 to 17 years. We found that at age 13 the plasma LH and FSH response to one LH-RH injection was normal. After the age of 14, the basal plasma concentration of LH and FSH and their response to LH-RH became elevated. Concomitantly the plasma testosterone levels rose to abnormal levels. These findings are compatible with progressive development of primary gonadal dysfunction and with peripheral insensitivity to testosterone.

17-Ketosteroids↗
PubMed1976

Human chorionic gonadotropin stimulation of Leydig cell function in puberty. Comparison of testosterone response in plasma and urine.

The plasma and urinary testosterone response to one i.m. injection of 5,000 IU human chorionic gonadotropin (HCG) was tested in 45 children and adolescents of several diagnostic entities: testosterone was measured before the injection and on the second, fourth and sixth days thereafter. It was found that there was a better correlation between the testosterone concentrations and the different pubertal stages than between testosterone concentration and either chronological or skeletal age. In the children with normal pubertal development, there was a slight rise in basal testosterone concentration with the progression of the pubertal stages. HCG caused a rise in plasma and urinary testosterone: this response was more marked in pubertal stages 4 and 5. The urinary response was variable whereas the changes in plasma testosterone concentration were more constant. In children and adolescents with primary or secondary hypogonadism, the basal levels of testosterone were low or undetectable and there was only a slight response to the single dose of HCG. It was concluded that a single i.m. injection of 5,000 IU HCG and the determination of plasma testosterone before, and two and four days after injection is a useful screening test for Leydig cell function.

Adolescent↗
PubMed1975

Identification by retarded and nonretarded children of stimuli varying along one, two, or three dimensions.

The effects of number and type of dimension of stimulus variation, type of dimensional combination, and delay of response upon the identification performance of retarded and nonretarded children were examined. A retarded-nonretarded subject difference in identification ability and delay effects found in an earlier study (Smith & Kaufman, 1972) was replicated, and a developmental effect for nonretarded children was found as well. A retarded-nonretarded subject interaction was indicated for the effects of increasing number of dimensions of variation and for the effects of type of dimensional combination (figure-figure combinations as opposed to figure-ground combinations).

Adolescent↗