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Biomedical subjects

H Katano

Publications and source records attributed to H Katano.

64 records · Page 4Linked to original sources
PubMed1996

Turbo spin-echo magnetic resonance imaging depiction of facial nerve compression by a vertebral artery in a patient with hemifacial spasm--technical note.

Turbo spin-echo magnetic resonance (MR) imaging of a patient with hemifacial spasm clearly demonstrated vascular compression of the facial nerve by the vertebral artery. The high resolution images of this method may be an appropriate alternative to preoperative cerebral angiography. Turbo spin-echo MR imaging is a diagnostic procedure of choice for patients with hemifacial spasm and possibly trigeminal neuralgia.

Adult↗
PubMed1995

Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM/ALK: a distinct clinicopathologic entity.

Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin's lymphoma characterized by the CD30+ large neoplastic cells and sometimes carries a t(2;5)(p23;q35). Recently, we found a novel hyperphosphorylated 80-kD protein tyrosine kinase, p80, in ALCLs with t(2;5). Subsequent cDNA cloning showed p80 to be a fusion protein of two genes, the novel tyrosine kinase gene and the nucleophosmin gene, in accordance with the sequence of the NPM/ALK gene (Morris et al, Science 263:1281, 1994). Meanwhile, the clinicopathologic features of p80-carrying ALCLs have remained unclear. Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80. Clinicopathologic comparison between p80-positive and -negative ALCLs showed that p80-positive cases occurred in a far younger patient age group (16.2 +/- 12.9 years; p80-negative cases, 51.0 +/- 22.3 years; P < .0001) and the patients showed a far better 5-year survival rate (79.8%; p80-negative group, 32.9%; P < .01). These data showed that p80-positive ALCL is a distinct entity both clinically and pathogenetically and should be differentiated from p80-negative ALCL.

Adolescent↗
PubMed1995

Measurement of regional cerebral blood flow with H2(15)O positron emission tomography during Matas test. Report of three cases.

The authors carried out a Matas test with a regional cerebral blood flow (rCBF) study using H2(15)O positron emission tomography (PET) for three cases of large internal carotid artery aneurysms. There is a likely correlation between the cerebral blood flow (CBF) reduction rate obtained by PET, and the mean stump pressure available from a conventional balloon occlusion test. The advantages of this noninvasive and quantitative method are presented in comparison with other methods.

Blood Flow Velocity↗
PubMed1995

Immunoglobulin idiotypic specificity of AIDS-associated lymphomas and their experimental model.

B cell non-Hodgkin's lymphoma (B-NHL) occurring in immunocompromised hosts, such as acquired immune deficiency syndrome (AIDS) patients, is a high-grade malignancy resistant to regular chemotherapy. To determine whether immunotherapy with public anti-Ig idiotype antibodies can be used to treat these NHL, the Ig idiotype specificity of six NHL in AIDS patients (AIDS-ML) and 23 B-NHL experimentally induced in immunocompromised mice (SCID mice) was investigated. One of the six AIDS-ML and two of the 23 experimental B-NHL reacted monoclonally with a single public antibody, while one AIDS-ML and three experimental B-NHL reacted polyclonally with two or three different antibodies. The presence of Ig idiotypic polyclonality requires special consideration with regard to the introduction of anti-Ig idiotype immunotherapy in these cases.

Adult↗
PubMed1995

Endovascular stent placement for multiple aneurysms of the extracranial internal carotid artery: technical case report.

A patient with multiple extracranial internal carotid artery aneurysms that caused cerebral infarction was treated by endovascular placement of a metallic stent. Complete disappearance of the aneurysms was angiographically confirmed within 15 weeks. Endovascular observation 6 months after the stent placement revealed that the endoluminal surface was totally covered by normal endothelium. The patient returned to his regular work routine and had no complication or neurological deterioration during the 17-month follow-up period.

Carotid Artery, Internal↗
PubMed1994

West syndrome associated with porencephaly.

A 3-year-old boy with West syndrome who was shown to have a cystic lesion on magnetic resonance imagings underwent surgical treatment. He had been initially managed with several antiepileptic drugs, but abnormalities on electroencephalography (EEG) persisted. Histological examination of the cystic wall obtained during surgery suggested porencephaly. Two years and 2 months later the child remained seizure-free and his EEG remarkably improved.

Adrenocorticotropic Hormone↗
PubMed1994

[Developmental changes in protein secretion in rat whole saliva].

Environmental conditions in the oral cavity may modulate the morphological and functional changes during the developmental process in the tissue. Saliva is one of the important factors among them. The purpose of this study is to investigate the proportional changes in the salivary proteins in accordance with the development. Male Wistar-strain rats were maintained from 3 to 12 weeks of age and once a week mixed saliva was collected from the oral cavity for 10 minutes after an intraperitoneal pilocarpine injection under anaesthesia. Salivary proteins were separated by SDS-polyacrylamide gel electrophoresis and silver-stained. The densitometric percentages of the stained protein bands were compared between samples of different weeks. The amount of total protein secretion increased with age, whereas the changes in the proportion of various proteins were inconsistent. Increase or decrease was found in the proportion of several protein components. The result indicated quantitative changes in the salivary protein composition in the developmental stage. A prominent increase of a protein band having an apparent molecular weight of 35 Kd was detected. This protein was identified as DNase I by its N-terminal amino acid sequence.

Aging↗
PubMedDate not supplied

Expression of human herpesvirus 8 (HHV-8)-encoded immediate early protein, open reading frame 50, in HHV-8-associated diseases.

OBJECTIVES: To investigate the expression of the open reading frame (ORF) 50 protein, a human herpesvirus 8 (HHV-8)-encoded immediate early protein, in HHV-8-associated diseases. STUDY DESIGN/METHODS: We developed a rabbit anti-ORF50 protein polyclonal antibody, and investigated the ORF50 protein expression by immunohistochemistry using primary effusion lymphoma (PEL) cell lines and tissue sections of Kaposi's sarcoma (KS), HHV-8-associated solid lymphoma, and multicentric Castleman's disease (MCD). RESULTS: Western blot analysis revealed that this antibody reacted with a 110-kd protein in the lysate of phorbolester-stimulated HHV-8-infected PEL cell lines. Immunohistochemistry revealed that a very small population of cells expressed the ORF50 protein in KS and HHV-8-associated solid lymphoma cells, and almost all these cells expressed HHV-8-encoded latency-associated nuclear antigen. The ORF50 protein expression was also rare in the cells of PEL cell lines, and the staining pattern was diffuse or dot-like in the nuclei, overlapping partially with that of promyelocytic leukemia protein. In MCD, however, the ORF50 protein was expressed in some cells of the mantle zone of the lymphoid follicle. CONCLUSIONS: The ORF50 protein expression in vivo was considerably rare in KS, HHV-8-associated solid lymphoma, and PEL, but was more frequent in MCD. Rare expression of this transactivator protein in HHV-8-associated malignancies causes low expression levels of other lytic proteins and may play a role in the maintenance of the latent infection. This is the first report describing the expression of an immediate early protein of HHV-8 in cases of HHV-8-associated diseases.

Castleman Disease↗