[Values of fine-needle aspiration biopsy of the liver under ultrasonic guidance in combination with cytology and histology in diagnosis of hepatic neoplasms].
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Biopsy, Needle↗
Biomedical subjects
H Kasugai
Publications and source records attributed to H Kasugai.
[Cytologic changes following intratumoral high dose injection of OK-432 in advanced pancreatic cancers and gall bladder cancers with ultrasound guidance].
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Aged↗
MR features of various histological grades of small hepatocellular carcinoma.
Twenty small hepatocellular carcinomas (HCCs) < 20 mm in diameter in 18 patients, detected by MRI, were surgically resected and histologically confirmed. Quantitative analysis of signal intensity on MR images was performed with 14 homogeneous lesions. In the five grade I HCCs, T1-weighted SE sequences provided significantly higher mean tumor-liver contrast and contrast-to-noise ratio (C/N) than T2-weighted SE sequences (p < 0.01). However, in the other nine HCCs (grade I + II or greater), T2-weighted SE sequences had significantly higher mean tumor-liver contrast and C/N values than T1-weighted SE sequences (p < 0.001). The T2-weighted SE sequences appear superior to T1-weighted SE sequences for grade I + II or greater HCC detection, whereas T1-weighted SE sequences are valuable in the detection of grade I HCCs.
Aged↗
Usefulness of diagnostic criteria for aspiration cytology of hepatocellular carcinoma.
OBJECTIVE: To establish new criteria for cytodiagnosis of hepatocellular carcinoma by comparing cytologic findings of hepatocellular carcinoma with those of liver cirrhosis. STUDY DESIGN: Review of cytologic findings of hepatocellular carcinoma on preoperative aspiration biopsy of 31 lesions from 27 patients who underwent surgical resection and comparison of these findings with those of liver cirrhosis in 17 patients. RESULTS: In the 11 lesions of moderately and poorly differentiated hepatocellular carcinoma, significant cytologic findings included monotonous and abundant cytoplasm, thick cytoplasm, increased nuclear/cytoplasmic ratio, irregular nuclear contours, increased chromatin density, intranuclear vacuoles and naked nuclei. In the 20 lesions demonstrating well-differentiated hepatocellular carcinoma, significant cytologic findings included monotonous and scant cytoplasm, well-defined cytoplasmic borders, thick cytoplasm, eccentric nuclei, increased nuclear/cytoplasmic ratio, thick nuclear membranes and increased chromatin density. We established the criteria for moderately and poorly differentiated hepatocellular carcinoma as including three cytologic parameters: increased nuclear/cytoplasmic ratio, irregular nuclear contours and increased chromatin density. We also established the criteria for well-differentiated hepatocellular carcinoma as including six cytologic parameters: monotonous cytoplasm, scant cytoplasm, well-defined cytoplasmic borders, thick cytoplasm, eccentric nuclei and increased nuclear/cytoplasmic ratio. For all 31 hepatocellular carcinoma lesions, including 27 lesions that were < or = 2 cm in diameter, both sensitivity and specificity were 100% by concurrently employing both criteria. CONCLUSION: The new criteria for cytodiagnosis we established were useful for differentiating hepatocellular carcinoma from liver cirrhosis. In particular, our criteria ensured appropriate diagnostic accuracy for well-differentiated hepatocellular carcinoma.
Aged↗