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Biomedical subjects

H Kastendieck

Publications and source records attributed to H Kastendieck.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Flow cytometric determination of DNA distribution patterns of malignant and benign tumors of the prostate (author's transl)].

56 samples of prostates, clinical suspected of being carcinomas, were examined by flow cytometry concerning their DNA distribution patterns. Carcinoma was diagnosed in 25 cases. All histologically benign samples showed a G1-fraction higher than 95%. Accordingly all cases with a G1-fraction lower than or equal to 95% were interpreted to be flow cytometrically positive (= malignant). The results of flow cytometric measurements essentially depend on the relation of the compounds of the sample--carcinomatous and normal tissue. Concerning the DNA distribution pattern, highly differentiated carcinomas do obviously not always differ from normal tissue. Hence they can escape from flow cytometric proof. An improvement of the flow cytometric distinction between histologically malignant and benign samples is achieved by the introduction of correction procedures for background and cell aggregations.

DNA, Neoplasm↗
PubMed1980

[The incidence of regional lymph node metastases in operable prostatic carcinoma (author's transl)].

Operation specimens of 165 radical prostatectomies were examined systematically for their pathological anatomy. In 22 cases (13.3%) there were metastases in the obturator and (or) iliac lymph nodes, in 12 cases these were micro-metastases with a maximal diameter of 2 mm. Ten were classified as N1, 7 ad N2 and 5 as N4. Lymph node involvement increased with increasing tumour staging: from 10% in T2 to 26.3% in T3. All metastasizing tumours had invaded the capsule (P3), 77% had additional infiltration of the seminal vesicles and in 73% the tumour volume was at least 50% that of the prostate. Thus prostate carcinoma must reach a certain size and penetrate the capsule before lymph node seeding occurs. The rate of metastases increases ninefold when the seminal vesicles are infiltrated. All metastasizing prostate cancers were polymorphic and in 73% the tumour differentiation in the metastases was identical. The findings as regards localisation of the tumour in the prostate and the metastases correlated in 91%. This result leads one to suspect a regular course of laterally localised spread in which the group of obturator lymph nodes appears to lie in the primary lymph drainage area of the prostate. The prognostic significance of regional lymph node metastases cannot yet be evaluated.

Aged↗
PubMed1977

[Pathomorphology of the human prostate gland].

The pathologic processes of the adult human prostatic gland, which consist of regressive and atrophic changes as well as of benign hyperplastic, metaplastic, dysplastic and carcinomatous proliferations, are analysed by light and electron microscopy. The examinations give rise to a new concept of the morphogenesis of each separate lesion. The results show the importance of the prostatic basal cell for the development of the special benign and malignant proliferations of the glandular epithelium. The histologically defined different alterations in the human prostatic gland are the results of the various differentiation possibilities of the basal cell.

Atrophy↗
PubMed1976

Carcinoma and dysplastic lesions of the prostate. A histomorphological analysis of 50 total prostatectomies by step-section technique.

50 prostate carcinomas which were totally prostatectomized together with removal of the seminal vesicles in all cases and pelvic lymphadenectomy in 38 cases were studied histologically. The material was cut by step-section technique in 5 mm thick slices and "large area slides" were made. 4 of the 50 carcinomas were morphologically circumscribed (stage I), 6 tumors were limited to the organ (stage II) and 40 prostate carcinomas had already penetrated the capsule, i.e. fascia of Denonvillier (stage III). In 12 cases the seminal vesicles were involved, regional lymph node metastases were seen 8 times. The carcinomas were mainly localized in the peripheral part of the organ (28 X in the periphery, 21 X both peripherally and centrally and only 1 X in the centre). Multifocal tumor growth was found in 30 cases (60%). The main mass of tumor was mostly situated in the middle (25 X) and caudal (15 X) zone of the prostate. During the course of tumor growth the expansion was directed centrally but then mainly longitudinal and parallel to the urethra. By progressing tumor volume there was a noticeable increase in capsular penetration as well as infiltration of the seminal vesicles and lymph node metastases. Histologically 10 carcinomas showed a uniform pattern, a unique solid and/or cribriform tumor architecture was never observed. 90% of the pluriform carcinomas consisted of the morphological stage III.

Adenocarcinoma↗
PubMed1976

Cyto- and histomorphogenesis of the prostate carcinoma. A comparative light- and electron-microscopic study.

The fundamental histologic proliferation patterns of the prostate carcinoma are presented by the glandular and solid and/or cribriform structures. These were ultrastructurally analyzed from 28 carcinomas based on the cell forms in prostate carcinomas, which were already defined by electron microscope. These are characterized by their different cytoplasmic differentiation, whereby the singular cell types each represent a different functional state of a common tumor cell. The results indicate that the prostatic carcinoma develops morphologically in phases. The well-known growth patterns of the tumor are equivalent to its different states of development. In the first phase, a pattern develops out of a tumor stem cell (perhaps "primary atypical reserve cell"), which is either glandular or solid/cribriform, whereas this depends on the trend of the tumor cells to differentiate. The glandular structure possesses centrifugally proliferated glandular, often functionally deranged tumor cells, and shows signs of early stromal infiltration. The solid/cribriform pattern consists of centripetal proliferated, often less-differentiated tumor cells with or without lumen formation, and a peripheral layer of basal cells, whereby the idiopathic stroma architecture remains as it is. In the successive phase, stroma infiltration and destruction is distinctly marked durinaplastic" during tumor growth. Histologically, one often sees at this stage an "anaplastic" pattern; however, ultrastructurally its orign can be recognized as being glandular or solid/cribriform. The advanced stages of the tumor are furthermore characterized by a mixed cell pattern with all states of differentiation and by progressing tumor cell degeneration.

Adenocarcinoma↗
PubMed1976

[Ultrastructure and formal pathogenesis of embryonal rhabdomyosarcoma (author's transl)].

An embryonal rhabdomyosarcoma of the nasopharynx of a 10 year old boy is analysed with light and electron microscopy. With regard to cell shape and cytoplasmic features the following four tumour cell types could be distinguished: 1. Undifferentiated mesenchymal cells with a big loosely packed nucleus and a small cytoplasmic rim with only few cell organelles; 2. Undifferentiated tumour cells with a broad cytoplasmic body which contains a dense network of nonspecific intermediate filaments with a diameter of about 100 A; 3. Immature rhabdomyoblasts with randomly orientated specific myofilaments; 4. Fully differentiated rhabdomyoblasts with well developed myofibrils often showing a sarcomeric pattern. Glycogen deposits which were seen in great masses in many tumour cells were regarded to result from degenerative processes within the tumor. The cellular stages in the development of rhabdomyoblasts are basically identical to those known from the embryogenesis and regeneration of striated muscle. From these observations the two following developmental pathways are suggested: 1. Origin of the tumour from an undifferentiated mesenchymal cell; 2. Atypical regeneration of striated muscle which terminates in malignant progressive tumour growth. At present, the body of information about rhabdomyosarcomas supports the assumption of an origin from immature mesenchymal cells. Nevertheless, the second theory cannot be totally excluded.

Cell Differentiation↗
PubMed1976

[Coincidence of Hodgkin's disease and epithelioid-cell granulomatosis in liver and spleen].

Two of seventy patients with Hodgkin's disease who had exploratory laparotomy with liver biopsy and splenectomy were found to have extensive epithelioid-cell granulomas in liver and spleen. The coincidence of malignant tumour and epithelioid-cell granulomas of liver and spleen without lymph-node involvement is unusual. Knowing of the coincidence of Hodgkin's disease and such granulomas is clinically important because extensive diagnostic measures, including biopsy, are necessary in the differential diagnosis, and the patient's prognosis will depend on the therapeutic measures taken.

Adult↗
PubMed1976

[Morphological and clinical results after combined hormone and radiation therapy for carcinoma of the prostate (author's transl)].

83 prostatic carcinomas were analysed morphologically and clinically before and after combined therapy. The classification of these tumors is based on the proliferation pattern resulting in a group with only one and a group with a variety of growth patterns. The largest groups were carcinomas with glandular structures. On the basis of multiple biopsies the histologic regression of the tumors was determined. In 71% of the cases there was good agreement of morphological results and local palpation findings. Further analyses revealed a correlation between histological growth pattern of the carcinomas and degree of regression: prostatic carcinomas with glandular pattern showed more often a good regression after combined therapy than solid and(or) cribriform tumors. In the groups with a variety of structural pattern the degree of regression was dependent on the prevailing tumor structure. According to these results the organoid-glandular carcinomas of prostate are prognostically more favourable than all the other proliferation patterns. Nevertheless in a single case a prognosis of the therapeutic effect based only on the tumor differentiation can not be made.

Aged↗