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Biomedical subjects

H Karlsson

Publications and source records attributed to H Karlsson.

At least 73 records · Page 4Linked to original sources
PubMed1995

Psychiatric morbidity among frequent attender patients in primary care.

In this study, 96 frequent attender patients in primary care were compared with 466 other primary care patients. The focus was on psychiatric morbidity, current and former psychiatric treatment, and self-perceived need for treatment. The prevalence of psychiatric illness was much greater among frequent attender patients than other patients (54.0% vs. 24.0%, p < 0.001), and subclinical symptoms were common in both groups (34.0% vs. 43.2%). Depression and anxiety were the most common clinical entities among frequent attender patients. However, very few patients had psychiatric treatment and the self-perceived need for treatment was low. The significance of these findings is discussed in the paper.

Attitude to Health↗
PubMed1995

Influence of compounds affecting synthesis, modification and transport of proteins on the expression and release of interleukin-2 receptor.

One of the most central events during lymphocyte activation is the synthesis and release of IL-2. IL-2 induces the synthesis and expression of the IL-2 receptor alpha-chain (IL-2R) on the lymphocyte as well as the release of a truncated form of IL-2R (sIL-2R). The two proteins are identical except for the absence of the transmembrane and intracellular part on sIL-2R. We have in an in vitro model investigated the influence of certain compounds, affecting different parts of the proliferative response, on the release and expression of IL-2R. We found the generation of the two molecules to have different sensitivity to blocking of protein synthesis, glycosylation, microtubular assembly and proteolytic activity. However, blocking of intracellular transport from Golgi to the endoplasmic reticulum, disassembly of actin filaments and disturbances in the intracellular sodium/calcium balance had identical effects on expression and release of the respective IL-2R. These findings indicate a more complex and specific mechanism behind the generation of sIL-2R than simply by shedding through the action of proteases on the membrane-bound IL-2R.

Aprotinin↗
PubMed1995

Factors predicting readmissions in personality disorders and other nonpsychotic illnesses. A retrospective study on 64 first-ever admissions to the Psychiatric Clinic of Turku, Finland.

A retrospective study of factors predicting readmissions and follow-up treatment was undertaken of all first-ever episodes of inpatient care (age under 65), excluding psychotic and organic mental disorders, during 1987 and 1988 in University Psychiatric Clinic in Turku City Hospital, Finland. The cohort consisted of 64 subjects, 24 men and 40 women. The study was carried out in the end of 1993, thus allowing about 5 years of follow-up. The diagnosis of personality disorder did not predict readmission. The only factor predicting readmission nearly significantly was not having a relationship. The incidence of the revolving door syndrome, defined as 4 or more admissions within 5 years, was 12.5%. Women had a greater risk of readmission, but not that of the revolving door. Patients who had psychotherapy as follow-up treatment showed a frequency of 8% for 4 or more admissions, whereas patients who had no follow-up treatment had a frequency of 21% for 4 or more readmissions. The only factor significantly predicting follow-up treatment arrangement was previous treatment contact.

Chronic Disease↗
PubMed1995

The ability of general practitioners to detect mental disorders in primary health care.

The ability to detect mental disorders varies greatly among general practitioners in primary health care. The aim of this study was to determine the factors underlying the differences between general practitioners in the ability to recognize mental disorders in Finnish patient populations. The group studied consisted of 1000 randomly selected adult patients of primary care facilities in the city of Turku. The Symptom Checklist (SCL-25) was used as the reference method in the identification of psychiatric cases. According to the SCL-25, one fourth of the sample had mental disorders. A good recognition ability was associated with postgraduate psychiatric training and qualification as a specialist in general practice. Surprisingly, Balint group training, which is a method intended to improve the ability of general practitioners to manage their patients' mental health problems, was associated rather with poor than good detection ability.

Adult↗
PubMed1995

Evaluation of methods for measurement of regional skin temperature and heat flow in neonates.

A reliable method for measurement of regional heat loss is a prerequisite for studies of heat loss in the neonate with different clothing and under varying environmental conditions. In the present study we evaluated methods for measuring regional skin temperature and regional dry heat loss in neonates, and specifically the influence of contact sensors applied to the skin surface. A modified incubator with controlled climate conditions was used as the climate chamber. The operative temperature was measured continuously with a black globe thermometer. Skin temperature was recorded with small-mass contact sensors and their influence on skin temperature was verified by simultaneous measurement with an infrared camera. The correlation was 0.99 and 1 SD within 0.3 degree C from the line of identity. The influence of the regional heat flow meter on skin temperature was also checked with an infrared camera and was found to be neglible.

Body Temperature Regulation↗
PubMed1995

Measurement of skin temperature and heat flow from skin in term newborn babies.

Regional heat loss and skin temperature changes in 25 healthy, full-term infants were studied under controlled conditions at environmental temperatures of 28-32 degrees C. Skin temperatures for all body regions followed changes in operative temperatures. Regional dry heat losses closely followed the external temperature gradient (difference between skin and operative temperature). The technique allows measurement of regional dry heat loss from the newborn skin exposed to different environmental conditions for different body surface areas. Thermal conductance, as an index of cutaneous blood flow, was calculated in a subgroup of 8 of the 25 babies by decreasing the operative temperature by 3-4 degrees C from the assumed thermoneutal zone. Thermal conductance indicated that only the foot responded to lower temperatures with vasoconstriction. Blood flow index of the chest region increased in all babies at lower temperatures.

Body Temperature Regulation↗
PubMed1995

Are frequent attenders of primary health care distressed?

OBJECTIVE: To measure the level of distress among frequent attenders of primary health care. DESIGN: A cross-sectional study. SETTING: Two public primary health care stations in Turku, south-western Finland PARTICIPANTS: 96 frequent attenders (eleven or more visits to a physician during the previous 12 months) and 466 control patients. MAIN OUTCOME MEASURE: SCL-25, GP evaluations, self-reported symptoms and self-experienced need for care. RESULTS: Frequent attenders were significantly more distressed than other patients in primary care. However, their self-experienced need for psychiatric care was very low and it did not differ from other patients self-experienced need. The GPs estimated that over 1/3 of frequent attenders suffered from mixed (physical and psychiatric) illnesses and over 1/2 from subclinical or clinical psychiatric symptoms. The corresponding proportions for other patients were significantly lower.

Cross-Sectional Studies↗
PubMed1994

Frequent attenders of Finnish public primary health care: sociodemographic characteristics and physical morbidity.

In this article results of a Finnish study on frequent attender patients of public primary health care are reported. These patients (n = 96) were compared with other patients (n = 466) attending the same surgeries. Frequent attender patients tended to have lower vocational training and to belong to lower social groups than other patients. The frequent attender patients also had more physical diseases, were more often on disability pension and had more mixed (physical-psychiatric) complaints than the control patients. The results indicate that many frequent attender patients complaints form a complicated network departing from different levels (physical, psychological and social). The implications of the findings are discussed.

Adolescent↗
PubMed1994

Isolation and characterization of a rat testis glycosphingolipid based on gangliotetraosylceramide and having a blood group B determinant extended with beta 3-linked N-acetylgalactosamine.

Monoclonal antibody 14.2, directed against the GalNAc beta 3Gal alpha 3Gal beta epitope, was used to monitor the isolation of a novel glycosphingolipid from rat testes. Structural analysis was performed by mass spectrometry, proton NMR spectroscopy, gas chromatography-mass spectrometry after degradation, and exoglycosidase digestion. It was concluded that the structure was [formula: see text] This is the first report on an extended blood group B determinant.

ABO Blood-Group System↗
PubMed1994

SCL-25 and recognition of mental disorders reported by primary health care physicians.

A marked proportion of primary care patients have mental disorders and problems that remain unrecognized by the patients and their general practitioners. There is furthermore a great variation in the physicians' ability to detect mental disorders. The aim of the present study was to find out the overall prevalence of mental disorders among patients receiving primary health care. The material consisted of 1000 randomly selected adult patients attending primary care facilities in Turku. The mental disorders were assessed by using the Symptom Checklist (SCL-25) and by general practitioners. According to the SCL-25, one fourth of the sample had a mental disorder. Only two fifths of them could be identified by the general practitioners.

Adolescent↗
PubMed1993

Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine.

The highly glycosylated domains of rat small intestinal mucins were isolated after reduction and trypsin digestion and separated into two populations (A and B) by gel chromatography. The molecular mass values were 650 and 335 kDa, respectively, and the relative yields suggest that the two glycopeptides occur in equimolar proportions. Electron microscopy revealed linear structures with weight average lengths of 230 nm (A) and 110 nm (B) corresponding to a mass/unit length of about 3 kDa/nm. The protein cores (17-19%) contain large amounts of threonine (over 40%), serine (17-24%), and proline (18-19%). Carbohydrate and sulfate account for approximately 80 and 0.5%, respectively, and gas chromatography-mass spectrometry showed that the patterns of neutral and sialic acid-containing glycans are very similar in the two glycopeptides. Both contain a significant amount (7-10 mol %) of single GalNAc residues, the average oligosaccharide is about 4 sugar residues long, and the largest species observed are heptasaccharides. The major neutral and sialic acid-containing oligosaccharides are Fuc1-2Gal1-3GalNAcol and GlcNAc1-6(NeuGc2-Gal1-3)GalNAcol, respectively. Sialic acid is present as both N-acetyl- and N-glycoloyl-neuraminic acid. Repeated extractions of the tissue with guanidinium chloride left approximately 80% of the mucus glycoproteins as an insoluble glycoprotein complex whereas exposure to dithiothreitol or high speed homogenization accomplished complete solubilization. The "subunits" obtained after reduction with dithiothreitol are larger than glycopeptides A and B, and fragments corresponding in size to the latter are obtained after cleavage with trypsin. Most of the mucins from rat small intestine thus occurs as an insoluble glycoprotein complex composed of subunits joined with disulfide bonds. The subunits contain two highly glycosylated regions with different lengths substituted with very similar oligosaccharides.

Amino Acids↗
PubMed1993

Management of a giant intracranial aneurysm using surface-heparinized extracorporeal circulation and controlled deep hypothermic low flow perfusion. A case report.

Extracorporeal circulation with controlled hypothermic low flow perfusion was introduced during the surgical treatment of a patient with a giant intracranial aneurysm of the anterior communicating artery. Heparin-coated equipment (Carmeda Bio-Active Surface; CBAS) was utilized, thus reducing the need for systemic heparinization. Direct cannulation of the right atrium and aorta was established through thoracotomy. Blood flow through the circuit was kept at 4.5 l/min during normothermia. Core cooling, in combination with external surface cooling, was performed for 30 min to a temperature of 18 degrees C (nasopharynx). During a period of 25 min, the time for surgical repair of the aneurysm, blood flow was minimized to 0.4 l.min-1, equilibrating central and peripheral blood pressures to approximately 5-10 mmHg (0.65-1.3 kPa). Reperfusion was started immediately after the low flow period concomitantly with rewarming, aiming at a temperature of 36 degrees C following 150 min. The patient could be weaned off the extracorporeal circulation with minimal inotropic support. The postoperative course was uneventful apart from a left-sided hemiparesis, probably due to an infarction in the area of the right pericallosal artery (A2). The patient was weaned off the ventilator after 6 days. He recovered and the hemiparesis regressed slowly.

Aged↗
PubMed1993

The influence of heparin-coated and uncoated extracorporeal circuits on blood rheology during cardiac surgery.

The effect of heparin-coated perfusion circuits on blood trauma during clinical cardiopulmonary bypass (CPB) was studied in order to find out if traumatic changes in the blood could be minimized. Twenty-four patients undergoing coronary artery bypass surgery were randomized prospectively to CPB with heparin-coated circuits (HCC) or non-coated circuits (NCC). The trauma to blood was assessed by measuring damage to blood cells by estimating red and white cell rheology changes. These were measured as red cell filtration rate (RFR) and white cell filtration rate (WFR) using standard microfiltration methods. Furthermore, changes in plasma hemoglobin (P-Hb), whole blood and plasma viscosity were simultaneously assessed. The RFR was significantly reduced in both groups during CPB by 10% in the HCC and 32% in the NCC groups (p less than 0.01). When comparing the HCC and NCC groups, a significant difference was first seen after 30 minutes of bypass (p less than 0.05) and increased at the end of CPB (p less than 0.01). Similar results were seen regarding WFR (15% and 36%, p less than 0.01). After 30 minutes of bypass, a significant difference was seen between HCC and NCC groups (p less than 0.05). Furthermore, a significant increase in P-Hb levels were seen during CPB in both patient groups. At the end of CPB, there was a significant difference in P-Hb levels (HCC 305+/-90 mg/L; NCC 455+/-78 mg/L, p less than 0.01) when comparing the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗