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Biomedical subjects

H Karasawa

Publications and source records attributed to H Karasawa.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Thoracic and lumbar sympathetic ganglion block for post herpetic neuralgia].

Of 2,667 patients with herpes zoster who visited our hospital between January 1972 and March 1989, 136 patients whose treatments were started after more than 6 months following the onset were subjects of the present study. Thus we performed a retrospective study of the therapeutic effects of sympathetic ganglion block (using alcohol) on postherpetic neuralgia left untreated for more than 6 months after the onset. After more than 1 year following the onset, the disease was nearly or completely cured in 9 of 37 patients (24%) treated with sympathetic ganglion block with alcohol and in 6 of 34 (17.6%) without the treatment. Thus the patients who underwent sympathetic ganglion block with alcohol tended to show better results. The above findings suggest that, in patients with postherpetic neuralgia in whom the initiation of treatment was delayed, treatment mainly consisting of thoracic or lumbar sympathetic ganglion block using alcohol in combination with antidepressants and antianxiety drugs can greatly improve patients' activities of daily life and that, at present, this method is most effective in relieving postherpetic neuralgia.

Aged↗
PubMed1989

[Palinopsia caused by tentorial meningioma. Case report].

Palinopsia is defined as persistence or recurrence of a visual image when the stimulus is no longer present. The authors describe a female patient with a left tentorial meningioma who experienced recurrent visual images. Computed tomography revealed a well demarcated, high-density mass above the left side of the tentorium, but formal field testing revealed no visual field defect. The findings in this case suggest that the palinopsia may have been the result of disordered temporal synthesis of visual experiences.

Female↗
PubMed1989

Effect of pirenzepine on aminopyrine uptake by isolated guinea pig parietal cells.

The inhibitory action of pirenzepine on acid secretion of isolated guinea pig parietal cells was investigated by the aminopyrine method. Pirenzepine markedly inhibited acid secretion of isolated parietal cells induced by carbachol in a dose-dependent manner but showed no inhibition on acid secretion stimulated by histamine. These results may suggest a direct action of pirenzepine on muscarinic receptors in parietal cells.

Aminopyrine↗
PubMed1989

[The administration of continuous epidural block under prone position with fluoroscopic guidance].

Continuous epidural block is often used for the treatment of pain. But there have been unsuccessful cases by the routine blind method. We devised a modified method of administering continuous epidural block under prone position with fluoroscopic guidance. The purpose of this study was to evaluate the utility of our modified method. There were 18 cases with pain of lumbar region and 28 cases of thoracocervical region in whom it was not possible to obtain successful control of pain by routine method. By our method, 14 cases (77.8%) with pain of lumbar region and 24 cases (85.7%) of thoracocervical region had effective epidural catheterization. There was no complication. As unsuccessful cases were accompanied with epidural adhesion or psychological disease, they might have no indication for continuous epidural block.

Analgesia, Epidural↗
PubMed1988

The effect of omeprazole on ultrastructural changes in gastric parietal cells.

This study was designed to compare the effects of omeprazole and cimetidine on ultrastructural changes in parietal cells of guinea pigs during histamine stimulation. Both omeprazole and cimetidine remarkably inhibited acid secretion induced by histamine stimulation. Omeprazole, however, failed to prevent the morphological transition of parietal cells to an active stage during histamine stimulation, in contrast to cimetidine which inhibited the morphological transition. In addition, it was noticed that administration of omeprazole caused vacuolation in approximately 27% of all parietal cells. This phenomenon was not seen in control animals with histamine stimulation alone and only very rarely in cimetidine treated animals. Ultrastructural findings suggested that vacuoles originated in secretory canaliculi of parietal cells. These results may be the key to explain the difference of the inhibitory mechanism between omeprazole which acts on the final step of intracellular process (so-called proton pump) and cimetidine which acts on the H2-receptor site of plasma membrane.

Animals↗
PubMed1987

Chronic subdural hematomas. Time-density curve and iodine concentration in enhanced CT.

Surgery was undertaken on 32 chronic subdural hematomas in a series of 28 patients who had preoperatively undergone delayed contrast-enhanced computed tomography (DCECT). Time-density curves on DCECT and iodine concentrations of subdural specimens revealed that chronic subdural hematomas, regardless of density, were significantly enhanced by the entrance of intravascular contrast medium into the interior of hematomas. The ingress of intravascular contrast medium into the interior of the hematomas was chemically proven and might result from a complex transcapillary shift.

Adult↗
PubMed1984

Isolation of parietal cells from guinea-pig gastric mucosa by a Percoll density gradient.

Isolation of parietal cells from guinea-pig gastric mucosa was performed by density gradient centrifugation using percoll, a new gradient medium composed of colloidal silica coated with polyvinylpyrolidone. The gastric mucosa of the oxyntic gland area was exfoliated, minced and digested with 2.0 mg/ml of dispase and 0.1 mg/ml of collagenase. Dispersed mucosal cells were applied to the percoll density gradient. Parietal cells were fractionated in the layer between 1.04 and 1.06 g/ml in density with purity 80 approximately 90%. For identification of parietal cells staining with tetranitrobluetetrazolium and electron microscopy were used in addition to common staining. The viability of the cells was over 95% assessed by trypan-blue exclusion. The parietal cells obtained responded actively to histamine stimulation when 14C-aminopyrine uptake was used as an functional index. In conclusion, percoll density gradient medium is suitable for yielding isolated parietal cells with both high purity and high viability.

Aminopyrine↗
PubMed1980

[Giant intracranial aneurysm visualized by prolonged injection angiography--case report (author's transl)].

A case of giant intracranial aneurysm which almost completely occluded the internal carotid artery and was diagnosed angiographically by prolonged injection technique was reported. A 62-year-old house-wife was admitted to the Department of Neurosurgery of The Asahi General Hospital, complaining of headache, nausea, and left ptosis. Neurological examination revealed left IInd, IIIrd, IVth, and VIth cranial nerve palsy. Films and laminagrams of the skull demonstrated the double floor of the sella trucica. Plain CT scan showed an oval high density area without surrounding low density area in the left middle cranial fossa. A left carotid angiogram revealed almost complete occlusion of the internal carotid artery at the foramen lacerum. Good cross filling through the anterior communicating artery was seen in the right carotid angiogram. Pre-operative diagnosis was pituitary tumor which extended to the middle cranial fossa. Left fronto-temporal craniotomy was performed and the tumor was suspected to be a giant intracranial aneurysm. Post-operative carotid angiogram by prolonged injection technique also showed a blood channel in the aneurysm and a part of the aneurysm. Left carotid ligation was carried out following intracranial surgery and her symptoms were remarkably improved. Apart from left VIth cranial nerve palsy she showed no abnormal neurological findings at discharge. Usefulness of the prolonged injection technique for differential diagnosis of the parasellar tumor was stressed.

Carotid Artery Diseases↗