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Biomedical subjects

H Kammermeier

Publications and source records attributed to H Kammermeier.

At least 73 records · Page 4Linked to original sources
PubMed1980

States of myocardial metabolism related to ischemia.

Energy metabolism of the heart in ischemia is mainly characterized by oxygen deficiency and lack of lactate removal. However, under certain circumstances substrate deficiency might contribute to disturbances of energy supply as well. Capillary permeability was determined from tracer washout kinetics of isolated hearts. Regulation of mitochondrial respiration was estimated from the relationship of phosphorylation potential vs. oxygen consumption. The results obtained suggest that at least under experimental conditions substrate supply at the level of capillary exchange can be a rate-limiting figure, as well as substrate supply at the mitochondrial level, i.e., NADH supply. The latter was inferred from the effects of cobalt and strontium ions on the regulation of respiration.

Animals↗
PubMed1975

Is substrate supply of the myocardium limited by capillary exchange?

Data of tracer wash-out kinetics of substrates and other substances permit the calculation of myocardial capillary exchange rates. Transfer rates calculated from these data and from known plasms substrate concentrations are close to the extraction rates observed by several authors. The substrate pattern offered for the myocardial cell, calculated from the capillary transfer, is also very similar to that extracted. These findings indicate that myocardial substrate consumption is determined and, under certain circumstances, even limited by capillary exchange. Limitation of capillary substrate transfer might act as a bottleneck of myocardial energy metabolism and might induce myocardial cell necrosis under certain conditions.

Animals↗