Recombinant interleukin (IL-2) was administered to 16 patients with HBe antigen-positive chronic active hepatitis in which the diagnosis was ascertained histologically. In 7 of the 16 patients, a decrement of the serum HBe antigen value was observed (Group A). In group A, the findings showed an increment of peripheral Leu 11-positive cells and NK and LAK cell activity, an acute exacerbation during and after IL-2 administration, disappearance of HBc antigen observed in liver biopsy histology, and decrement of serum DNA-p activity. However, seroconversion of HBs antigen was not observed and no case showed the elimination status of continuous HB virus infection. On the other hand, in the other 9 patients (Group B), these changes were not observed and the existence of a HLA type difference between Group A and B was shown by HLA analysis. These results indicated that the immune responses mediated by IL-2 may play an important role in the development of chronic hepatitis B, and these results may be regulated genetically.

Adult↗

PubMedDate not supplied

Experimental study on thermal damage to dog normal brain.

We investigated the temperature changes and their distribution in agar phantoms and dog normal brains induced by 8 MHz radiofrequency interstitial hyperthermia and observed the histological changes, with respect to the neurons and myelinated nerve fibres, induced by the same heat source in dog normal brains. We also examined the change of blood-brain barrier permeability using Evans blue solution. The heating limits of dog normal brain were 42 degrees C for 45 min or 43 degrees C for 15 min and the breakdown of the BBB was observed at 43 degrees C for 60 min.

Animals↗

PubMedDate not supplied

Splenic blood flow in idiopathic portal hypertension in Japan measured by 85Kr clearance method.

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Adolescent↗

PubMedDate not supplied

Beta-blocking action of bopindolol, a new beta-blocker, and its active metabolites in open chest dogs.

The beta-blocking activity of bopindolol, a new nonselective beta-blocker, and of its active metabolites (18-502 and 20-785) was compared with that of propranolol and atenolol in anesthetized open chest dogs. No remarkable changes in basal cardio-hemodynamic parameters were observed in all groups, except for dp/dtmax which was decreased in the bopindolol-, propranolol-and atenolol-treated groups. All beta-blockers used inhibited the isoproterenol (0.1 microgram/kg, i.v.)-induced tachycardia and the increase in myocardial oxygen consumption dose-dependently. The active metabolite 18-502 was the most potent; it was 19 times as potent as propranolol with respect to the antitachycardic action and 34 times as potent as propranolol in inhibiting the increase in oxygen consumption induced by isoproterenol (0.1 microgram/kg). The potency of bopindolol was nearly equal to that of propranolol, while the potency of atenolol and the metabolite 20-785 was weaker than that of propranolol. As 18-502 was found as a metabolite also in man, it is suggested that 18-502 is a more important active metabolite of bopindolol than 20-785 in in vivo conditions, though the metabolite 20-785 is also a potent beta-blocker.

Adrenergic beta-Antagonists↗

PubMedDate not supplied

Glucocorticoid-unresponsive fever in a patient with Weber-Christian disease.

Weber-Christian disease, a disease of unknown aetiology, is characterised by relapsing febrile episodes and systemic panniculitis. Glucocorticoid therapy is often useful during acute phases of the disease. This report describes a patient in whom hyperpyrexia did not respond to high-dose glucocorticoid treatment, yet did respond to a non-steroidal anti-inflammatory drug (NSAID).

Adult↗