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Biomedical subjects

H Kala

Publications and source records attributed to H Kala.

At least 37 records · Page 2Linked to original sources
PubMed1987

[The polymorphism of drugs in powders and tablets. 4. The effect of the polymorphism of drugs on the physical properties and drug release of phenobarbital tablets].

Four products of phenobarbital (I, II1, II2, III) are manufactured into tablets with the dry binders Avicel PH 101 or Heweten 40 using different pressures by direct tabletting. The physical properties of the resulting tablets are different according to the modification of phenobarbital, the binders used and the pressure during tabletting. The dissolution behaviour of the drug may be changed by the different technological and physical parameters.

Chemical Phenomena↗
PubMed1986

[Phase transformation of carbamazepine by the milling process].

In the present paper the interconversion behavior of the carbamazepine modifications I, II and III under various grinding conditions (variation of milling aggregates, milling times and frequencies) were studied. Mechanical treatment of different crystal forms led to a uniform grinding product, which is characterized crystallographically as modification III. The kinetic of phase transformations were determined by means of various quantitative methods such as a IR-spectral, a X-ray-powder diffractional and a thermoanalytical one. The results obtained by different analytical methods accorded quite well.

Carbamazepine↗
PubMed1986

[Description of the process of in vitro liberation of matrix tablets].

After a short description of the drug liberation process from a porous matrix the influence of the matrix forming substance on the drug liberation is characterized. The compression process is the decisive step in forming the hydrophobic, nondissolved matrix. The temporal lapse of the in vitro liberation process of the model drug quinidine is demonstrated by means of electronmicroscopical photographies.

Drug Compounding↗
PubMed1986

[The influence of plasticizers on the permeability of polymethacrylate films (Eudragit RS)].

Pellets with pholedrine sulphate are coated by means of a fluid-bed process with polymethacrylates and increasing portions of plasticizers. The addition of PEG 6000 increased the film permeability. On the other hand triacetin effected no change and dibuthyl phthalate decreased the permeability in relation to films without plasticizers. When the films were contacted 8 h with phosphate buffer (pH = 7,4) PEG could not be detected and triacetin film contents was reduced to about 30%. Unlike that the portion of dibuthyl phthalate decreased insignificantly.

Dibutyl Phthalate↗