Search PubMed⌕ Search

Biomedical subjects

H K Johnson

Publications and source records attributed to H K Johnson.

At least 73 records · Page 4Linked to original sources
PubMed1978

Urinary tract calculous disease after renal transplantation.

We report 3 cases of a series of 372 (0.8 per cent) renal transplant recipients in whom urinary tract calculi developed as a complication of the procedure. In each patient symptoms were minimal and not classic of calculous disease. We disagree with the contention that all such patients have either hypercalcemia, infection, or tubular acidosis, although thorough evaluation is indicated. We believe this entity should be considered in problematic renal transplantation patients. Conservative therapy is advocated when the situation permits.

Adult↗
PubMed1976

Massive skeletal trauma in renal transplant patients.

A review of 251 renal transplants done at the Vanderbilt University Medical Center since October 1962 revealed three patients who had suffered subsequent skeletal injuries sufficient to cause hospitalization. In a 37-year-old woman, a closed fracture of the pelvis healed satisfactorily in the usual period of time. In a 30-year-old man, closed fractures healed well, but there was prolonged delay in the healing of massive open wounds resulting from crushing injuries of the lower extremities. He required prolonged hospitalization, but satisfactory result was achieved after early amputation and close cooperation between orthopedic and renal teams. No significant alterations in the function of either patient's transplanted kidney occurred. It is postulated that severe trauma in transplantation patients may become more common in the future, and certain guidelines for its management are set forth. With close cooperation between the orthopedic surgical and medical renal teams, a successful outcome can be expected.

Adult↗
PubMed1976

Long-term hemodialysis for patients over 50.

Hemodialysis can hodl end-state renal failure at bay and enable patients to lead a relatively normal life-regardless of their age. In a 10 year retrospective study of 574 patients, the 154 patients over 50 had about the same survival rates as younger persons for the first three years of dialysis. After that, the older patients had higher mortality. Patients who dialyzed themselves at home-with a relative or friend to help-had much better results than those who were dialyzed at the center. This in part reflects the selection process, since patients with severe medical problems usually weren't allowed to try self-dialysis. Older patients did particularly well on home dialysis, which was attributed to their maturity and dependability. Older patients with cardiac instability may require carefully monitored dialysis at the center and frequent blood transfusions. In general, though, patients over 50 needed fewer transfusions and fewer days in the hospital than younger patients.

Aged↗
PubMed1975

Renal autograft survival after perfusion and hypothermic storage in a hyperosmolar high potassium-containing solution.

A hyperosmolar high postassium-containing kidney perfusate and storage solution with demonstrated in vitro advantages over extracellular-like solutions was tested for renal preservation superiority in vivo. A model allowing simultaneous evaluation of creatinine clearance of both kidneys from the same animal, each having been perfused and stored for 24 hours in different preservation solutions, offered certain advantages over conventional models. Immediate function, greater ultimate creatinine clearance and preservation of cellular architecture during 24 hours of hypothermic storage was demonstrated convincingly in kidneys preserved in the hyperosmolar high potassium containing solution. Simplicity of preparation and absence of precipitates were additional desirable features of this solution. The use of Ringer's lactated solution for perfusion and cold storage of kidneys should be avoided.

Animals↗
PubMed1975

Preformed cytotoxic antibody in patients subjected to thoracic duct drainage.

1. Patients subjected to TDD prior to transplantation had a 4-yr graft survival rate of 65% compared to a comparably HL-A-matched group in which the survival rate was 35%9 2. Patients classified as non-responders to tissue antigens have a much higher graft retention rate than responders. Responders subjected to TDD have a 1 yr graft survival rate of 62% compared to a comparably HL-A-matched group with a survival rate of 28%. 3. Individuals with a positive crossmatch or receiving second or third transplants and subjected to TDD do much better than such individuals not subjected to TDD.

Cytotoxicity Tests, Immunologic↗