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Biomedical subjects

H K Beyer

Publications and source records attributed to H K Beyer.

At least 91 records · Page 5Linked to original sources
PubMed1982

[Causative investigations of heparin-induced rise on thyroid hormone serum levels (author's transl)].

Intravascular application of heparin causes a significant rise of free and total thyroid hormone concentrations in serum together with a concomitant drop of the TSH-levels. A causal relationship between these two findings has been firmly established by a number of investigators. The decline of TSH concentrations in serum after heparin injection might just be a physiological reaction of the pituitary gland to the heparin-triggered rise of serum thyroid hormone levels. The present investigations demonstrate a diminution of affinity of thyroid hormone receptors of liver cells. This result confirms the hypothesis that the rise of total thyroid hormone in blood is mainly due to a depletion of liver stores of thyroid hormones. In concordance with clinical findings the binding affinity of cellular pituitary thyroid hormone receptors was found to increase.

Heparin↗
PubMed1982

[Assay of protein and thyroid hormone concentrations in hemofiltrate (author's transl)].

To assess protein and thyroid hormone loss during hemofiltration estimation of protein and thyroid hormone concentrations in the hemofiltrate were carried out. The protein loss during one week amounted to 4-6 g. Weekly loss of T4 was about 1,5 microgram, that of T4 0,5 microgram. These quantities are negligible and of no clinical relevance. Therefore substitutions of protein loss by albumin or thyroid hormones do not seem to be required in patients undergoing hemofiltration.

Blood↗
PubMed1981

[Serial determination of carcinoembryonic antigen in the follow-up of patients with malignant tumours (author's transl)].

Carcinoembryonic antigen (CEA) was determined serially in 54 patients with malignant tumour (other than colorectal ones). Patients in remission (21), those resistant to treatment (16) and a group not receiving treatment (17) showed a good correlation between growth behaviour of the tumour and titre changes. Best correlation was in 21 patients who after treatment with cytostatic agents, hormones or radiation had objective signs of remission. Serial determination of CEA is thus of value in the control of treatment of malignant tumours other than those of the colorectum.

Adult↗
PubMed1981

[The in-vitro-effects of loxaglate (Hexabrix) on coagulation, fibrinolysis and complement system (author's transl)].

Ioxaglate causes a dose dependent prolongation of thrombin time, thrombin coagulase time, partial thromboplastin time and calcium thromboplastin time. A substantial activation of fibrinolysis, assayed by a dose dependent decrease of plasminogen concentrations, does not take place. Higher concentration of ioxaglate (more than 25 mg iodine/ml) cause a complement activation. No C-3 split products could be detected by two-dimensional immunoelectrophoresis. Ioxaglate induced changes of global coagulation tests are interpreted as being caused by interference of fibrin polymerization. The demonstration of complement activation by high concentrations of ioxaglate has no practical consequences.

Blood Coagulation↗
PubMed1981

[Studies on Hypothalamic-Pituitary Thyroid regulation in Hemodialysis Patients (author's transl)].

During hemodialysis a continuous determination of free thyroid hormone and the basic TSH value was performed in 43 patients. a significant increase of free thyroxine and triodthyronine was found as well as a significant decrease of the TSH basal concentration in serum, which was already subnormal before hemodialysis. In 14 patients a TSH-TRH-test was performed before, during and after hemodialysis. A considerable reduction of the pituitary sensitivity to TRH administration during dialysis was found as compared with values before and after hemodialysis. Because of the increase of free hormone concentration, the reduction of TSH serum concentration and the decrease of pituitary sensitivity to TRH are considered to be a physiological reaction of the pituitary. On the other side a significant increase of the binding affinity of the T3 and T4 nuclear cell receptors correlated with concentration of heparin could be demonstrated. Because this modulation would induce an increasing occupation of the binding valences with thyroid hormone molecules, with a resulting decrease of the production of TSH, this process could also explain the results. Because ther is only a linear relation between the number of occupied nuclear binding sets and the TSH metabolism for T3, the physiological reaction of the pituitary is dependent on an intact conversion of T4 to T3 intracellular. A possible partly defect of this monodeiodination at hemodialysis patients could also explain the published different results concerning the basic concentration of TSH in the serum and the TSH-THR-test.

Humans↗
PubMed1981

[In vitro effect of Iopamidol on coagulation, fibrinolysis and complement system (author's transl)].

Experiments on the effect of iopamidol on coagulation, fibrinolysis and complement system by in vitro standard tests were undertaken. No effect on thrombin time and thrombincoagulase time were found in clinically relevant concentration range. In contrast to classical triiodinated contrast media indications of inhibition of fibrin polymerization could only be found at large doses of iopamidol. No generation of fibrinolytic split products as indication of activation of fibrinolysis were found. Crossed immunoelectrophoresis at different concentrations could not detect split products of the complement protein C3.

Blood Coagulation↗
PubMed1980

[Thyroid function in patients with kidney insufficiency requiring hemodialysis (author's transl)].

In 43 hemodialysis patients different thyroid function parameters have been assessed. A characteristic combination of findings occurred in most cases. These were reduced values of total hormones in serum with normal free hormone levels. There was a reduced occupation of binding valences for TBG and a subnormal TSH. The TSH-TRH tests were normal. These changes in serum concentration can be explained at best by accepting a modulation of binding valences of transport proteins in the sense of reduced binding affinity. The various possible inducing mechanisms are discussed and the high sensitivity of binding valences to changes of the acid-alkaline equilibrium and temperature underlined. Both factors may play a role in uremic patients. Since not only in uremic patients but also in patients with various other diseases such changes in serum level can be demonstrated, there is a good chance that different mechanisms induce the same effect.

Humans↗
PubMed1980

[Determination of the concentration of thyroid hormones in dialysate and assessment of the loss of thyroid hormone during hemodialysis (author's transl)].

In order to determine the hormone concentration in a dialysate, the commercially available radioimmunoassay test of Dow-Lepetit for determination of free thyroid hormones in serum had to be modified. The results raised the suspicion that additional protein-bound hormone had passed the membrane. This could be demonstrated by the addition of Thiomersal. In 64 patients examined 1 and 5 hrs after the beginning of hemodialysis the mean total hormone concentration in the dialysate was 12.05 pg/ml for thyroxine and 5.47 pg/ml for triiodothyronine. The resulting loss of total hormone in hemodialysis patients, calculated for 1 week, amounted to 2.25 microgram triiodothyronine and 4.87 microgram thyroxine. The comparison with the physiologic renal elimination of thyroid hormone shows that the hormone elimination in hemodialysis patients is negligibly small. The quantitative determination of the protein concentration in the dialysate gave 384 ng/ml and was close to the limit of sensitivity of the method and consequently uncertain. It can be said, however, that the loss of protein is without clinical relevance.

Humans↗
PubMed1980

[Assessment of the loss of thyroid hormone during hemodialysis by administration of a hormone tracer in an in vitro experiment (author's transl)].

Several investigators have examined thyroid function in hemodialysis patients. Similar results were obtained: reduced total triiodothyronine and subnormal thyroxine values in serum. This raised the question whether a deficiency in hormones during hemodialysis could be responsible for these findings. The present studies were ade in an attempt to prove or disprove this assumption by determining hormone loss. The loss of thyroxine during hemodialysis was 1.1 microgram. This order of magnitude excludes a hormone deficit caused by dialysis. The assumption that an increased loss of hormone during hemodialysis is the cause of pathologic changes in the serum as compared with the period before dialysis can be considered as disproved.

Humans↗
PubMed1979

[Carcinoembryonic antigen (CEA) and CEA-like activities in ascites and pleura-effusions (author's transl)].

Carcinoembryonic antigen (CEA) was assayed in 18 samples of non-malignant and 21 samples of malignant effusions. In 95% of benign effusion CEA activity was found within normal limits and increased only in one case of Klebsiella pneumonia. In 57% of the 21 malignant effusions CEA levels were elevated and in 4 cases elevated titers were first indications of the malignancy of the effusion. In some cases remarkable differences between serum titer and effusion titer were found. Combined measurement of CEA activity in plasma and effusion increases diagnostic value.

Ascites↗