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Biomedical subjects

H Jimenez

Publications and source records attributed to H Jimenez.

10 recordsLinked to original sources
PubMed1992

Clinical comparison of technetium-99m-teboroxime and thallium-201 utilizing a continuous SPECT imaging protocol.

To examine the advantages of a 99mTc-labeled cardiac perfusion agent, teboroxime or SQ30,217 (Squibb Diagnostics), a prospective study was undertaken comparing it to 201Tl stress testing in 17 patients suspected or known of having coronary artery disease (CAD). All patients were studied utilizing a single-detector SPECT camera with a continuous acquisition imaging protocol. Testing was performed on a treadmill to comparable levels with both agents within a 2-wk period. Concordance between the two studies on a patient by patient basis was seen in 16/17 (94%) patients, and discordance was seen in 1/17 (6%) patients. Comparison of findings between 201Tl and 99mTc-teboroxime on a segment by segment basis showed concordance in 107/119 (90%) segments, and 12/119 (10%) were discordant. Both examinations independently detected an equal number of normal (77) and abnormal (42) segments. There was no significant difference between the two agents in classifying lesions as ischemic, although there were significant differences between thallium and teboroxime in classifying infarct and infarct/ischemia. Technetium-99m-teboroxime SPECT imaging is a clinically useful method for detecting CAD, with a major advantage being the shorter examination time per individual patient study. The mean total examination time for completion of the 99mTc-teboroxime study was 2.5 hr versus 4.0 hr for 201Tl.

Aged↗
PubMed1987

Penetrating wounds of the back and flank: analysis of 77 cases.

To determine the factors that allow early recognition of injuries to the intrathoracic and intra-abdominal organs in patients with penetrating wounds to the lower thorax and abdomen with site of entrance located in the back or flanks, we retrospectively analyzed the cases of 77 such patients. There were 65 stab wounds (85%) and 12 gunshot wounds (15%). The injuries were confined to the abdomen in 46 (60%); 39 were stab wounds and seven were gunshot wounds. The wounds were confined to the chest in 24 patients (31%) and involved both the chest and abdomen in seven cases (9%). Of the 53 abdominal wounds, 21 necessitated celiotomy; in 20 of them, an intra-abdominal organ was found injured, and one patient died (1.9%). Of the 24 injuries confined to the chest, only one patient required emergency thoracotomy due to massive hemorrhage; all 24 patients survived. All of the seven thoracoabdominal injuries, two produced by gunshot and five by stabbing, necessitated celiotomy. Most patients with gunshot wounds to the back and flanks require celiotomy, but a selective therapy can be safely used in patients with stab wounds. The rate of negative exploratory celiotomy was less than 5%; the mortality was 1.3%.

Abdominal Injuries↗
PubMed1983

Clinical implications derived from the morphological classification of 89 patients with acute pancreatitis.

A morphologic categorization of pancreatitis which can only be made at operation or at autopsy has prognostic and therapeutic implications. We reviewed 89 such cases and classified them as follows: 1) Edematous in 54 (60.7%). All patients underwent operation; five (9.2%) died. 2) Necrotizing in 20 (22.5%). Eighteen patients required operation. Seven (39%) patients died; two patients treated nonoperatively died. 3) Hemorrhagic in 15 (16.8%). Operation was performed in nine with five (55.5) deaths; six patients treated without operation died. These observations suggest that 50% of patients operated on for pancreatitis have the mild edematous form; most of them survive the operation. In the severe forms of pancreatitis with necrosis or hemorrhage of the pancreas, about 50% of patients die postoperatively. There were no survivors in those treated without operation, suggesting the usefulness of surgical treatment once pancreatic necrosis is suspected. However, the advisability of operation and the prognostic implications derived from the morphologic categorization of acute pancreatitis are applicable (only retrospectively) after the pancreas has been examined at operation.

Acute Disease↗
PubMed1982

Effects of various operations on the electrical activity of the human stomach recorded during the postoperative recovery period.

This study attempts to characterize any changes occurring in the human gastric control electrical rhythm (CER), following a variety of gastric surgical procedures. Pairs of electrodes were implanted in selected specific sites on the stomachs of 57 patients undergoing either antrectomy and vagotomy, proximal gastric vagotomy (PGV), vagotomy and drainage, gastric resection without vagotomy, or fundoplication. Five patients undergoing nongastric operations served as controls. After operation recordings were obtained with differential preamplifiers, an oscilloscope, and a dual-channel tape recorder. An electrical signal compatible with a CER was found almost always in the distal body or antrum, regardless of whether vagotomy was performed. In contrast, a CER was found only occasionally in the fundus, and was never found following PGV. Although there was a difference in the frequency of occurrence of fundic CER in patients with and without vagotomy, it was not statistically significant (p = 0.0668). Patients with prolonged postoperative convalescence because of gastric atony were compared with patients with normal postoperative courses regarding the presence or absence of CER in the gastric antrum or fundus. A statistically significant relationship between abnormal gastric motility and absence of CER was not established.

Eating↗
PubMed1982

Autocorrelation, cross correlation and coherence analyses of the electrical activity of the human stomach in the postoperative period.

Electrical potentials generated by the stomach have been well categorized. They vary in amplitude, shape, frequency and time relationships and may be contaminated by electrical activity from other organs. In addition to visual observation, this investigation used methods of autocorrelation and cross correlation, spectral analysis and coherence determinations to refine and numerically characterize gastric electrical potentials. Bipolar Teflon coated electrode wires were brought out through the abdominal wall in six patients, four of whom underwent fundoplication, one of whom underwent cholecystectomy and one of whom underwent portacaval shunt. Recordings were obtained until the ninth postoperative day using differential preamplifiers, an oscilloscope and a dual channel tape recorder. Oscilloscope displays were photographed, and the outputs of the tape recorder were filtered in the analog mode. Similar recordings were also obtained postoperatively in a patient with gastric stasis, and a surface electrode was used to record the gastric electrical activity of a normal volunteer. The propagation time, electrical control activity frequencies and bioelectrical dependence or independence between the two measuring sites were clearly differentiated by these methods. This method offers a safe and feasible way of recording and analyzing the electrical activity of the human stomach in the postoperative period with statistically specified reliability. This is accomplished through temporarily implanted wires, and, potentially, from the surface of the body, even during electrical interference.

Electrodes, Implanted↗
PubMed1980

Evaluation and treatment of acute and chronic pancreatitis. A review of 380 cases.

The cases of 380 patients with pancreatitis were analyzed retrospectively. There were 237 men (62%) and 143 women (38%). Etiologic factors included: alcoholism, 62%; biliary lithiasis, 16.6%; idiopathic, 12%; miscellaneous, 7%; and trauma, 2.4%. Acute pancreatitis occurred in 279 patients (73%); 189 (67%) were treated nonoperatively, 90 (33%) underwent operation; electively in 43 and urgently in 47. Postoperatively, one patient (2.3%) died in the elective group and 14 (30%) in the emergency group. Chronic pancreatitis occurred in 101 patients. Their pertinent findings were: alcoholism in 78%, biliary lithiasis in 8%, absence of abdominal pain in 15%, diabetes in 40%, and jaundice in 20%. Fifty patients were treated without operation; 43 were alcoholics, 17 of them died in the follow-up period. Fifty-one patients, 36 of them alcoholics, underwent a variety of operations, with three deaths (6%); 21 were improved after operation. It was concluded that 30% of patients with acute pancreatitis require operation, mainly to correct biliary lithiasis. Emergency operations dictated by relentless deterioration or uncertain diagnosis had a high operative mortality (30%), particularly in patients with necrotizing or hemorrhagic pancreatitis. Operative treatment for chronic pancreatitis was most effective when directed toward specific goals, including pseudocysts, obstructed pancreatic or common bile ducts. Operations done without specific anatomical objectives were often therapeutic failures.

Acute Disease↗
PubMed1977

Continuous tissue culture cell lines derived from chemically induced tumors of Japanese quail.

Several continuous tissue culture cell lines were established from methylcholanthrene-induced fibrosarcomas of Japanese quail. The lines consist either of fibroblastic elements, round refractile cells or polygonal cells. They show transformed characteristics in agar colony formation and hexose uptake, and most are tumorigenic. Their cloning efficiency in plastic dishes is not increased over that of normal quail embryo fibroblasts. The quail tumor cell lines do not produce endogenous avian oncoviruses and fail to complement the Bryan high titer strain of Rous sarcoma virus; those tested lack the p27 protein of avian oncoviruses. Most of the cell lines are susceptible to subgroup A avian sarcoma viruses, but are relatively resistant to viruses of subgroups C, E and F as compared to normal quail embryo fibroblasts.

Alpharetrovirus↗
PubMed1975

Fluorescamine as a terminating agent in solid phase peptide synthesis.

Fluorescamine was shown to be an excellent terminating agent for blocking unreacted amino groups during solid phase peptide synthesis. A comparison of the termination efficiency of fluorescamine versus that of acetylation revealed that the former method gave superior products as assessed by peptide analysis, dansyl-amino end group determination and biological assay. In addition, fluorescamine terminated fragments were converted to non-fluorescent spirolactones during the deprotection stage. These spirolactones were stable to subsequent solid phase reaction conditions and were readily removed from the target peptide.

Acetylation↗