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Biomedical subjects

H Jick

Publications and source records attributed to H Jick.

At least 235 records · Page 13Linked to original sources
PubMed1976

Myocardial infarction and estrogen therapy in post-menopausal women.

Data obtained from two multipurpose surveys of hospitalized patients were examined to determine the risk of nonfatal acute myocardial infarction in post-menopausal women 40 to 75 years of age in relation to use of estrogen-containing drugs. Eight (2.4 per cent) of 336 myocardial infarction patients and 330 (4.9 per cent) of 6730 reference patients were regular estrogen users (crude rate ratio, 0.47) at the time of hospitalization. After control for confounding variables -- among them, age, past history of myocardial in farction, angina, diabetes, and hypertension (alone or in combination) and cigarette smoking -- the summary point estimate of rate ratio was 0.97 with 95 per cent confidence limits of 0.48 and 1.95. Thus, there was no evidence of a statistically significant association between current regular use of estrogens and nonfatal acute myocardial infarction.

Acute Disease↗
PubMed1976

Rates of cutaneous reactions to drugs. A report from the Boston Collaborative Drug Surveillance Program.

Rates of allergic skin reactions to commonly used drugs were estimated from data obtained on 22,227 consecutively monitored medical inpatients. A total of 57 drugs were implicated with skin reactions. Five or more reactions were attributed to each of 22 drugs (or drug groups). Many commonly used drugs did not appear to cause any allergic reactions. The study provides the practicing physician with drug-specific quantitative data that can be used to evaluate the causes of drug-induced rash, itching, or hives.

Anti-Bacterial Agents↗
PubMed1976

Fatal drug reactions in patients admitted to surgical services.

In a defined group of 10,281 generally healthy inpatients admitted to surgical services, two deaths were identified as being due in part to an adverse effect of a drug, for a rate of 0.19 drug-related dealths/1,000 surgical patients (approximate 95 per cent confidence limits, 0.02 to 0.71/1,000). Both deaths occurred in women more than sixty years old and were due to hemorrhage associated with heparin therapy.

Adult↗
PubMed1976

Cigarette-smoking and nonfatal myocardial infarction: rate ratio in relation to age, sex and predisposing conditions.

The relationship of cigarette-smoking and nonfatal myocardial infarction (AMI) was evaluated using the case-control approach. Overall, the association was present for smokers of one and two packs per day, the standardized rate-ratio estimates being 1.5 and 1.7, respectively. The association was strongest in those who had a low risk score for AMI and particularly strong for people in the earliest (fifth) decade of age. People with diabetes and/or angina manifested no association between cigarette-smoking and AMI.

Adult↗
PubMed1976

Alcohol consumption and nonfatal myocardial infarction.

A study of the relathonship between alcohol consumption and nonfatal myocardial infarction, involving 399 cases and 2486 reference subjects, indicated absence of any major overall association (rate ratio point estimate of 0.9 with 95% confidence limits of 0.6 and 1.2), but there was some evidence of a lower rate in subjects consuming six or more drinks per day (rate ratio point estimate of 0.6 with 95% confidence limits of 0.3 and 1.1). Confounding by several potential confounders was controlled by stratification according to a confounder-summarizing score.

Adult↗
PubMed1976

Gentamicin- and cephalothin-associated rises in blood urea nitrogen.

Standardized rates of drug-attributed rises in blood urea nitrogen were 8.6%, 2.9%, and 9.3%, respectively, in patients receiving gentamicin alone, cephalothin alone, and both drugs together. These results provide evidence against a substantial synergism between the two drugs in the production of impaired renal function.

Adult↗
PubMed1976

Drug prescribing in hospitals: an international comparison.

This paper presents a comparison of prescribing habits for patients hospitalized in medical wards of university hospitals in America and Scotland. American patients received almost twice as many drugs both during and prior to hospitalization than did comparable Scots. The differences between the countries were consistent for symptomatic and for more specific therapies. As compared to Scotland, drug therapy in America costs patients more in terms of financial outlay and adverse drug effects. The data do not permit evaluation of the relative benefits to the patients of the different quantities or types of drug used for similar circumstances in these countries.

Anxiety↗