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Biomedical subjects

H Jenssen

Publications and source records attributed to H Jenssen.

At least 19 recordsLinked to original sources
PubMed2005

Anti herpes simplex virus activity of lactoferrin/lactoferricin -- an example of antiviral activity of antimicrobial protein/peptide.

One of the most common viral infections in humans is caused by the herpes simplex virus (HSV). It was first effectively treated in the 1970s with the introduction of acyclovir, which is still the most commonly used treatment. Naturally occurring antimicrobial proteins and peptides have also been shown to possess antiviral activity against HSV. This review will focus on the anti-HSV activity of one such protein, lactoferrin, and a small peptide fragment from its N-terminal domain, lactoferricin. Both components have been shown to effectively block entry of HSV into the host cell. In addition to blocking HSV entry, the peptides appear to have immune stimulatory activity, although this is still somewhat controversial. Mode of action studies and knowledge about the anti-HSV activity of lactoferricin have also been successfully employed in the design of new, more specific HSV blockers.

Amino Acid Sequence↗
PubMed2001

[Incidents connected to pregnancy and labor].

In the period 1993-2000 the Norwegian Board of Health investigated 70 cases of claimed professional misconduct in relation to pregnancy or delivery. There were two maternal deaths, 38 perinatal deaths and 17 cases of cerebral damage. The Board of Health found reason to criticize midwives in 11 cases, obstetricians in 39 cases, and the hospital for lack of routines in 18 cases. Many of the mishaps were connected to false interpretation of fetal signs of distress (clinical signs or cardiotocography), and the investigation concluded that Caesarean section was delayed too long. The number of patient complaints has been constant through the period, in contrast to the widespread belief that misconduct and complaints are steadily increasing. The health authorities and the Norwegian Association of Gynaecologists have focused on quality and standards in obstetrics through committees for investigation of perinatal deaths, national guidelines in obstetrics, and improved national statistics.

Diagnostic Errors↗
PubMed1995

Prediction of fetal weights in twins.

OBJECTIVE: To determine the accuracy of sonographic weight estimation of twin fetuses. METHODS: In 73 twin-pregnancies, fetal weight estimation by ultrasound was performed within 7 days prior to delivery. Fetal head biparietal diameter and abdominal circumference were measured. The coefficient of correlation (r), and the ratio between estimated weight and actual weight were calculated. RESULTS: The coefficient of correlation was r = 0.954 between estimated weight and actual birth weight. The ratio between the two parameters was 1.025, the standard deviation 0.089. In our study, 41% of the antenatal estimated weights deviated less than 5% from the actual birth weight. For 72% of all estimated weights, the deviation was less than 10%. Ultrasonographic prediction of actual weight below the 10th percentile level showed a sensitivity of 85%, predictive value of 80% and specificity of 87%. In detecting inter-twin discordance > or = 20%, the respective values were 64%, 64% and 91%. CONCLUSIONS: Antenatal estimation of birth weight by ultrasound correlates well with the actual weights of twin fetuses. Prediction of individual fetal weight seems to be more accurate than prediction of inter-twin discordance.

Adult↗
PubMed1980

Fetal systolic time intervals after paracervical block during labor.

Fetal systolic time intervals (FSTI) were recorded every 10th second (s) during uterine contractions in 25 paturients in the first stage of labor before and after paracervical block (PCB). Twentytwo patients had good or excellent relief of pain. The newborn infants were not depressed. After PCB the duration of the R--R and S1--S2 intervals increased. A close correlation was found between the R--R and S1--S2 intervals, both before and after PCB, and during early decelerations recorded before and after PCB. The S1--S2 The S1--S2 interval was prolonged after PCB, even after correction for the heart rate. The R--S1 interval and the amplitude of the first part of the first heart sound (S1a) also increased after PCB. The FSTI showed a conspicuous cyclic variation during uterine contraction. The S1a amplitude decreased after the peak of contraction, the others increased simultaneously. The results contradict the assertion that PCB causes fetal hypoxia or reduction of the maternal placental circulation. A centralization of the fetal circulation, possibly combined with a direct effect of local anesthetic on the fetal heart, would explain the changes found after PCB. The cyclic variation of the parameters during uterine contraction is probably caused by a transfer of blood between the placenta and fetus. The changes of myometrial dynamics after PCB, as shown by the alteration of the phases of the amniotic pressure curve, are compatible with this transfer of blood.

Adolescent↗
PubMed1979

Neurobehavioral response of infants after paracervical block during labour.

30 parturient women were randomized into a group receiving paracervical block (PCB) and a control group. The infants were tested by a neurobehavioral examination immediately after birth, after 3 hours and 3 days. The examiner was unaware of the obstetrical management of the patients. No clinically significant differences could be detected between the two groups. Arterial and venous pO2, pCO2 and pH from the umbilical cord showed no differences between the groups.

Adolescent↗
PubMed1978

Changes in fetal supraventricular extrasystoles during uterine contractions in labour.

The electrocardiogram and phonocardiogram were recorded from a fetus exhibiting supraventricular ectopic beats during labour. The ectopic beats showed increased amplitude of the first heart sound (S1) compared to sinus and postectopic beats; the R-S1 interval was prolonged and the mechanical systole, measured as the S1-S2 interval, shortened. During uterine contractions these parameters were measured every 10 sec. The S1 amplitude of the ectopic beats decreased; simultaneously the R-S1 interval increased and the S1-S2 interval shortened. The changes were delayed compared to the amniotic pressure curve. The changes found can be explained by a shift of blood between the fetus and placenta, caused by uterine contraction.

Adult↗
PubMed1977

The effect of dexamethasone therapy in prolonged pregnancy.

Fifty-six patients, chosen by random sampling from a total group of 120 post-term women, received dexamethasone (Decadron, "MSD" 2 mg 3 times a day for 4 days, the other 64 patients acting as controls. The evolution of uterine activity was evaluated using pelvic score (PS) and a modified low dosage oxytocin sensitivyt test (OST) before (T1) and after (T2) the treatment. During the interval from the second to the 6th day inclusive after T1 35 women of the dexamethasone group and 15 of the control group had a spontaneous onset of labour (SO) (0.001 less than P less than 0.01). Five patients in the dexamethasone group with primary rupture of membranes started labour spontaneously within 12 hours after membrane rupture, 7 patients in the control group with primary rupture of membranes received oxytocin as labour did not start within 24 hours. Excluding patients artifically induced, the mean interval from T1 to SO was 6.8 days in the control group and 5.2 days in the dexamethasone group (P less than 0.001). In both groups PS and the sum of Montevideo units (MU) during OST increased from T1 to T2, the increase was significantly greater in the dexamethasone group than in the control group. We found no correlation between the results of OST and the T1--SO interval. Dexamethasone, as used in this study, may promote labour in prolonged human pregnancy. Due to its low potency, it is not a substitute for oxytocin in the induction of labour. The lowered placento-fetal quotient in the dexamethasone group warrants further study of the effects of steroid hormone on placental function.

Administration, Oral↗