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Biomedical subjects

H Javid

Publications and source records attributed to H Javid.

72 records · Page 4Linked to original sources
PubMedDate not supplied

Neuroendocrine markers in paragangliomas of the head and neck.

Eighteen paragangliomas of the head and neck (11 carotid body tumors, four glomus tympanicum tumors, three glomus jugulare tumors) were studied retrospectively. Tissue from each of these tumors was immunostained for the presence of serotonin, a variety of neuropeptide hormones, and the enzyme neuron-specific enolase (NSE). Seven tumors were studied by electron microscopy. The clinical and laboratory records were reviewed for evidence of endocrine activity or metabolic imbalance. All tumors displayed diffuse and intense immunostaining for NSE. In addition, a wide variety of hormonal substances could be identified. Those most frequently demonstrated were serotonin and leu-enkephalin. Ten of the 11 carotid body tumors demonstrated immunoreactivity for multiple hormones. By electron microscopy all tumors contained a heterogeneous population of membrane-bound neurosecretory granules. None of these tumors was associated with a clinically apparent endocrine syndrome. We conclude that paragangliomas of the head and neck are neuroendocrine tumors that are capable of synthesizing a variety of hormonal substances. These hormonal substances rarely elicit a clinically apparent endocrine or metabolic imbalance. All of the tumors demonstrated immunostaining for NSE. Future studies on serum levels of NSE may provide useful diagnostic and follow-up data.

Carotid Body Tumor↗
PubMedDate not supplied

Superiority of aortic over femoral cannulation for cardiopulmonary bypass, with specific attention to lower extremity neuropathy.

The advantage of aortic cannulation over femoral cannulation in cardiopulmonary bypass has been well established in our experience. Over a four year period, we compared the incidence of complications of these two modalities in a large group of patients. Specific emphasis is placed on the lack of lower extremity neurological deficit and retrograde dissection in patients who underwent aortic cannulation.

Adult↗
PubMedDate not supplied

Reflections in a normal eye: the effect of aortic stenosis on oculopneumoplethysmography.

The association of aortic stenosis and syncope is well recognized. Oculopneumoplethysmography (OPG) can provide an accurate index of carotid stenosis and indirectly measure cerebral perfusion. The possibility that OPG would be influenced by aortic valve disease was assessed in patients prior to valve replacement. 31 patients were studied. 19 patients had aortic stenosis (AS), 3 had aortic insufficiency (AI), and 10 had mixed lesions. OPG was positive in 15 patients (48%). Considering all forms of aortic valve disease, the likelihood that a positive OPG was indicative of AS with a gradient of greater than 60 mmHg was significant (P = .002). Of 18 patients with AS alone, no patient with a valve gradient greater than 60 mmHg had a negative OPG (P = .0001). OPG became normal in 11 of 12 patients restudied postoperatively. Critical aortic stenosis results in uneven distribution of blood flow into the brachiocephalic vessels. OPG accurately identifies this effect which becomes evident at aortic valve gradients greater than 60 mmHg.

Aged↗