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Biomedical subjects

H Jacobs

Publications and source records attributed to H Jacobs.

At least 145 records · Page 8Linked to original sources
PubMed1980

The effect of repeated injections of 99mTc-antimony-sulphide colloid on the RES of the rat--histopathologic study.

Experiments on inbred albino rats were performed to test the effect of repeated administrations of 99mTc-antimony sulphide colloid on the integrity of the RES. Experiments were carried out in two batches, one with the preformed colloid given in increasing doses, and the other with the labelled colloid in increasing doses. In all, 9 groups of animals including a control group were tested. Studies included: organ weights of liver, spleen, lungs and kidneys, histopathology, contact macroautoradiography, microautoradiography and 99mTc activity distribution in organs. Results showed no macroscopic or microscopic evidence of tissue damage after repeated injections up to a total dose of 18 mCi 99mTc, 142.2 mg PVP, and 693 microgram Sb, given in 9 equivalent doses at one week intervals. It is concluded that repeated administrations of 99mTc-antimony sulphide colloid for liver scintigraphy are safe.

Animals↗
PubMed1976

Testicular neoplasm in siblings.

Two sets of testicular tumors involving nontwin siblings are reported. The possibility dysgenesis and dysgonesis and the totipotentiality of the cells in the pathogenesis of these tumors are described and discussed

Adult↗
PubMed1972

A trial of opipramol in the treatment of migraine.

A double blind trial of opipramol (Insidon) compared with placebo for a group of matched patients suffering from migraine has been carried out. The total number of the migraine attacks in a group of 14 patients on opipramol (as compared with the same patients during a pretreatment period of six weeks) showed a 33% reduction in the number of attacks experienced during the first six weeks. During a further consecutive six weeks after this on treatment, attacks were further reduced to 49% as compared with the pretreatment period. In the placebo group there was a 20% increase in the number of migraine attacks in the first six week treatment period as compared with the base line six weeks on no drugs. In the second consecutive six weeks migraine attacks were 2% more frequent than in the pretreatment period. These figures indicate that opipramol is a drug with considerable promise and effectiveness in the control of migraine attacks.

Adolescent↗