Immunostaging was performed in patients with chronic pancreatitis of different etiologic groups. Immune responifveness was assessed by immunoglobulin serum levels, non specific autoantibody formation, C3 levels, antistreptolysin reaction, antibody titer against Toxoplasma gondii, E. coli, Herpes simplex-, Mumps- and Cytomegalovirus and screening for soluble immune-complexes (PEG precipitation assay), number of T- and B-lymphocytes, lymphocyte responsiveness to PHA, PPD, tetatoxoid and mumps-antigen in a whole blood assay, skin testing with candidin, trichophytin, tuberculin and streptokinase and HLA-typing. In some cases we found a depressed cell-mediated immune responsiveness. Patients were divided into two groups based on this main finding. Cellular hyporesponsiveness was correlated to the severity of the disease and a high incidence of HLA-B5 but not to any etiologic factor of the disease.

Adult↗

PubMed1980

[African histoplasmosis].

This is a case report of two patients who suffered from African histoplasmosis. Clinical, histological, and mycological characteristics, and the treatment are described.

Adult↗

PubMed1979

[3H-thymidine-paper strip-counting of in vitro lymphocyte transformation. II. Specific antigens in the whole blood assay (author's transl)].

Erythrocytes did not influence the harvesting procedure or the paper strip counting method in a liquid scintillation counter using the whole blood assay of lymphocyte transformation test. The leucocyte-erythrocyte-ratio influences the blastogenesis in vitro. Only 1--2 ml of peripheral blood are necessary to proof lymphocyte reactivity to mitogens or antigens. The storage of the blood is possible over a period of 24 hours (4 degrees C) if the absolute lymphocytes count remains constant.

Adolescent↗

PubMed1979

[Intracutaneous tests with phytohemagglutinin for detection of cell-mediated immunity (author's transl)].

Patients with various forms of dermatosis and healthy control subjects were simultaneously tested intracutaneously with specific antigens (candidin, trichophytin, kabikinase, tuberculin and the mumps skin test antigen) and the non-specificmitogen PHA-P. A positive delayed reaction was observed in 98% of the healthy subjects and 76,6% of the dermatosis patients following intracutaneous application of 2 microgram PHA-P.--The results of these studies suggest that the PHA-P intracutaneous test might be suitable as a screening method for diagnozing cellular immun-defects.

Adult↗

PubMed1979

[African histoplasmosis (author's transl)].

Explore the source record for details and available documents.

Amphotericin B↗

PubMed1979

[African histoplasmosis in an Angolan woman: clinical aspects, histology and mycology].

Explore the source record for details and available documents.

Adult↗

PubMed1978

[Sézary syndrome. A case report].

This paper describes a patient who exhibits all signs of Sézary-syndrome. During the 15 years of sickness, the patient has developed a generalised erythrodermia, skin infiltrations, hyperkeratosis on the palms and the foot soles, changes in pigmentation, and generalised swelling of the lymph nodes. Two modifications of Sézary's cells have been found in the peripheral blood and the specific skin infiltrations by both light and electron microscopy. The serum contains large amounts of a macrophage migration inhibitory factor. The illness does not respond to chemotherapy.

Aged↗

PubMed1977

[Mycological studies of patients with hemoblastoses].

40 patients with haemoblastosis were examined clinically and by cultures for presence of yeast mycosis. Moreover, we analyzed specific antibodies with the help of cell agglutination, the passive haemagglutination and the precipitation using Candida antigen. 29 test persons were found having a yeast mycosis, 3 patients without clinical symptoms in pharynx showed presence of yeasts by culture, 8 test persons were clinically and mycologically negative. In cell agglutination we recorded titres of less than 1:20 to 1:5 160 and in haemagglutination titres of less than 1:20 to 1:5 160 and in haemagglutination such of less than 1:20 to 1:320. 5 patients showed positive precipitation reaction with antigen extracted of membranes of Candida albicans cells. We observed different titre motions with these patients: during illness the titre either rised or decreased clearly, or the patients were in a condition of humoral anergy against the Candida albicans antigen. It is hinted at the necessity to watch over susceptible patients mycologically.

Acute Disease↗