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Biomedical subjects

H J West

Publications and source records attributed to H J West.

31 records · Page 2Linked to original sources
PubMed1988

Clearance of bromosulphthalein from plasma as a measure of hepatic function in normal horses and in horses with liver disease.

Single intravenous injections of bromosulphthalein (BSP) were given to horses and the change in plasma concentration of BSP with time was analysed by computer to obtain the proportionality transfer constants 'a', 'h' and 'b'. No age, weight or sex differences in BSP clearance were found in normal horses. The technique was non-invasive, repeatable and suitable for conscious animals. The measurement of the transfer constants 'a', 'h' and 'b', helped to provide an accurate guide to diagnosis and prognosis of liver disease.

Animals↗
PubMed1987

Changes in the concentrations of bile acids in the plasma of sheep with liver damage.

The concentration of total plasma bile acids was measured in normal sheep and in sheep in which liver damage was induced by chronic copper poisoning, ligated bile ducts or induced ketosis. All three treatments produced a rise in total bile acid concentration in plasma which was proportional to the degree of hepatic damage seen histologically and which tended to parallel changes in activity of iditol, and glutamate dehydrogenase and aspartate amino-transferase in plasma. Plasma bile acid concentration was a more sensitive method of detecting these types of liver damage than was the measurement of total plasma bilirubin concentration, and could be used to assess alterations in liver function in sheep.

Animals↗
PubMedDate not supplied

The clearance of bromosulphthalein from plasma as a measure of the changes in hepatic function during pregnancy and lactation in ewes.

Single intravenous injections of bromosulphthalein (BSP) were given to sheep and the change in plasma BSP concentration with time was analysed by computer to obtain the proportionality transfer constants 'a', 'h' and 'b' and plasma volume. The BSP half-time, fractional clearance and retention values were also calculated. Alterations in BSP clearance were compared with changes in bilirubin and liver specific enzyme activities in ewes in late pregnancy and early lactation. The measurement of BSP clearance, particularly the proportionality transfer constants, yielded more information about the alterations in hepatocellular function during pregnancy and lactation than the changes in clinical chemistry. It is suggested that these alterations in liver function are physiological rather than pathological at these times.

Animals↗